TY - GEN
T1 - Correlating liver stiffness and splenic stiffness values in patients with chronic liver diseases using Magnetic Resonance Elastography
AU - Thangaraju, Shyam
AU - Mahadevappa, Manjunatha
AU - Venkatesh, Sudhakar K.
PY - 2010/12/1
Y1 - 2010/12/1
N2 - Magnetic Resonance Elastography (MRE) is a non-invasive Magnetic Resonance technique for measuring the stiffness of soft tissues, and several studies have shown that MRE accurately detect liver fibrosis [1][2][3][4]. In this study, data from 62 cases with different stages of liver fibrosis (histopathological examination and staged according to METAVIR [5] scoring system) were used. The stiffness values of liver and spleen (in kPa) were measured by placing circular regions of Interests (ROI's) in the software generated stiffness maps in the anatomical regions of liver and spleen respectively. The values were tabulated and correlation and regression analysis performed. Results show a Pearson correlation coefficient (r) value of 0.59 (P<60;0.0001) between the stiffness values of liver and spleen. The corresponding r2 value is 0.34. The Spearman rank correlation coefficient is 0.526. A simple linear regression model gives a slope of 0.7 with an intercept of 2.9 Kilopaspacls (kPa). These values suggest a moderate correlation between the stiffness values of liver and spleen.
AB - Magnetic Resonance Elastography (MRE) is a non-invasive Magnetic Resonance technique for measuring the stiffness of soft tissues, and several studies have shown that MRE accurately detect liver fibrosis [1][2][3][4]. In this study, data from 62 cases with different stages of liver fibrosis (histopathological examination and staged according to METAVIR [5] scoring system) were used. The stiffness values of liver and spleen (in kPa) were measured by placing circular regions of Interests (ROI's) in the software generated stiffness maps in the anatomical regions of liver and spleen respectively. The values were tabulated and correlation and regression analysis performed. Results show a Pearson correlation coefficient (r) value of 0.59 (P<60;0.0001) between the stiffness values of liver and spleen. The corresponding r2 value is 0.34. The Spearman rank correlation coefficient is 0.526. A simple linear regression model gives a slope of 0.7 with an intercept of 2.9 Kilopaspacls (kPa). These values suggest a moderate correlation between the stiffness values of liver and spleen.
KW - Magnetic Resonance Elastography
KW - liver
KW - spleen
KW - tissue stiffness
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U2 - 10.1109/ICSMB.2010.5735352
DO - 10.1109/ICSMB.2010.5735352
M3 - Conference contribution
AN - SCOPUS:79955686468
SN - 9781612840383
T3 - International Conference on Systems in Medicine and Biology, ICSMB 2010 - Proceedings
SP - 98
EP - 101
BT - International Conference on Systems in Medicine and Biology, ICSMB 2010 - Proceedings
T2 - International Conference on Systems in Medicine and Biology, ICSMB 2010
Y2 - 16 December 2010 through 18 December 2010
ER -