Correlating liver stiffness and splenic stiffness values in patients with chronic liver diseases using Magnetic Resonance Elastography

Shyam Thangaraju, Manjunatha Mahadevappa, Sudhakar K. Venkatesh

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Magnetic Resonance Elastography (MRE) is a non-invasive Magnetic Resonance technique for measuring the stiffness of soft tissues, and several studies have shown that MRE accurately detect liver fibrosis [1][2][3][4]. In this study, data from 62 cases with different stages of liver fibrosis (histopathological examination and staged according to METAVIR [5] scoring system) were used. The stiffness values of liver and spleen (in kPa) were measured by placing circular regions of Interests (ROI's) in the software generated stiffness maps in the anatomical regions of liver and spleen respectively. The values were tabulated and correlation and regression analysis performed. Results show a Pearson correlation coefficient (r) value of 0.59 (P<60;0.0001) between the stiffness values of liver and spleen. The corresponding r2 value is 0.34. The Spearman rank correlation coefficient is 0.526. A simple linear regression model gives a slope of 0.7 with an intercept of 2.9 Kilopaspacls (kPa). These values suggest a moderate correlation between the stiffness values of liver and spleen.

Original languageEnglish (US)
Title of host publicationInternational Conference on Systems in Medicine and Biology, ICSMB 2010 - Proceedings
Pages98-101
Number of pages4
DOIs
StatePublished - Dec 1 2010
EventInternational Conference on Systems in Medicine and Biology, ICSMB 2010 - Kharagpur, India
Duration: Dec 16 2010Dec 18 2010

Publication series

NameInternational Conference on Systems in Medicine and Biology, ICSMB 2010 - Proceedings

Other

OtherInternational Conference on Systems in Medicine and Biology, ICSMB 2010
CountryIndia
CityKharagpur
Period12/16/1012/18/10

Keywords

  • Magnetic Resonance Elastography
  • liver
  • spleen
  • tissue stiffness

ASJC Scopus subject areas

  • Medicine(all)

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    Thangaraju, S., Mahadevappa, M., & Venkatesh, S. K. (2010). Correlating liver stiffness and splenic stiffness values in patients with chronic liver diseases using Magnetic Resonance Elastography. In International Conference on Systems in Medicine and Biology, ICSMB 2010 - Proceedings (pp. 98-101). [5735352] (International Conference on Systems in Medicine and Biology, ICSMB 2010 - Proceedings). https://doi.org/10.1109/ICSMB.2010.5735352