Correlates of lymphoproliferative responses to measles, mumps, and rubella (MMR) virus vaccines following MMR-II vaccination in healthy children

Neelam Dhiman, Inna G. Ovsyannikova, Robert M. Jacobson, Robert A. Vierkant, V. Shane Pankratz, Steven J. Jacobsen, Gregory A. Poland

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Cell-mediated immunity (CMI) to measles, mumps, and rubella viral antigens plays a critical role in providing long-term protection against these infectious diseases. We examined CMI by measuring lymphoproliferative response induced in response to stimulation with the above three antigens following two doses of measles, mumps, and rubella-II (MMR-II) vaccine in a randomly selected, population-based cohort of healthy children. We determined if a correlative and predictive intraclass relationship exists between CMI to the three components of MMR-II. We detected positive lymphoproliferative responses to measles, mumps, and rubella vaccines. Mumps vaccine used as an antigen had the highest median stimulation index followed by measles and rubella vaccines. The overall intraclass correlation value for lymphoproliferative response to measles, mumps, and rubella using Pearson's correlation was 0.61 (95% confidence interval = 0.56, 0.66). We observed a significant pairwise association to individual vaccine components between subjects in the upper and lower 10th percentile of immune response. This study demonstrates recall CMI post-MMR-II vaccination with significant intraclass correlation among the CMI responses to the three vaccine components.

Original languageEnglish (US)
Pages (from-to)154-161
Number of pages8
JournalClinical Immunology
Volume115
Issue number2
DOIs
StatePublished - May 2005

Fingerprint

Measles-Mumps-Rubella Vaccine
Mumps virus
Rubella virus
Mumps
Measles virus
Rubella
Measles
Cellular Immunity
Vaccination
Vaccines
Mumps Vaccine
Rubella Vaccine
Measles Vaccine
Antigens
Viral Antigens
Communicable Diseases
Confidence Intervals
Population

Keywords

  • Cell-mediated immunity
  • Lymphoproliferative response
  • Measles
  • Vaccine

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Dhiman, N., Ovsyannikova, I. G., Jacobson, R. M., Vierkant, R. A., Pankratz, V. S., Jacobsen, S. J., & Poland, G. A. (2005). Correlates of lymphoproliferative responses to measles, mumps, and rubella (MMR) virus vaccines following MMR-II vaccination in healthy children. Clinical Immunology, 115(2), 154-161. https://doi.org/10.1016/j.clim.2004.12.010

Correlates of lymphoproliferative responses to measles, mumps, and rubella (MMR) virus vaccines following MMR-II vaccination in healthy children. / Dhiman, Neelam; Ovsyannikova, Inna G.; Jacobson, Robert M.; Vierkant, Robert A.; Pankratz, V. Shane; Jacobsen, Steven J.; Poland, Gregory A.

In: Clinical Immunology, Vol. 115, No. 2, 05.2005, p. 154-161.

Research output: Contribution to journalArticle

Dhiman, N, Ovsyannikova, IG, Jacobson, RM, Vierkant, RA, Pankratz, VS, Jacobsen, SJ & Poland, GA 2005, 'Correlates of lymphoproliferative responses to measles, mumps, and rubella (MMR) virus vaccines following MMR-II vaccination in healthy children', Clinical Immunology, vol. 115, no. 2, pp. 154-161. https://doi.org/10.1016/j.clim.2004.12.010
Dhiman, Neelam ; Ovsyannikova, Inna G. ; Jacobson, Robert M. ; Vierkant, Robert A. ; Pankratz, V. Shane ; Jacobsen, Steven J. ; Poland, Gregory A. / Correlates of lymphoproliferative responses to measles, mumps, and rubella (MMR) virus vaccines following MMR-II vaccination in healthy children. In: Clinical Immunology. 2005 ; Vol. 115, No. 2. pp. 154-161.
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