Corrections: Both HIV-infected and uninfected cells express TRAILshort, which confers TRAIL resistance upon bystander cells within the microenvironment (Journal of Immunology (2008) 200 (1110-1123) DOI: 10.4049/jimmunol.1701113)

Zilin Nie, Fatma Aboulnasr, Sekar Natesampillai, Stephen P. Burke, Ashton Krogman, Gary D. Bren, Thomas D.Y. Chung, Jeff R. Anderson, Michele K. Smart, David J. Katzmann, Govindarajan Rajagopalan, Nathan W. Cummins, Andrew D. Badley

Research output: Contribution to journalComment/debatepeer-review

1 Scopus citations

Abstract

FIGURE 6. TRAILshort is both necessary and sufficient to cause TRAIL resistance. (A) Jurkat T cells, which constitutively express TRAILshort, were induced to die by the addition of sk-TRAIL, in the presence or absence of increasing amounts of anti-TRAILshort Ab. Cell death was measured by active caspase-3 staining. Control cells were treated with increasing anti-TRAILshort Ab alone. (B) HeLa cells, which do not express TRAILshort, were stimulated to die by the addition of sk-TRAIL in the absence or presence of increasing amounts of a fusion protein consisting of the extracellular domain of TRAILshort fused to Fc (TRAILshort-ECD:Fc) or with BSA control and analyzed as in (A). Additional control cells were treated with increasing TRAILshort-ECD:Fc alone. Data are representative of six independent experiments. p < 0.05 considered statistically significant (linear regression).

Original languageEnglish (US)
Pages (from-to)1599
Number of pages1
JournalJournal of Immunology
Volume201
Issue number5
DOIs
StatePublished - Sep 1 2018

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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