Abstract
FIGURE 6. TRAILshort is both necessary and sufficient to cause TRAIL resistance. (A) Jurkat T cells, which constitutively express TRAILshort, were induced to die by the addition of sk-TRAIL, in the presence or absence of increasing amounts of anti-TRAILshort Ab. Cell death was measured by active caspase-3 staining. Control cells were treated with increasing anti-TRAILshort Ab alone. (B) HeLa cells, which do not express TRAILshort, were stimulated to die by the addition of sk-TRAIL in the absence or presence of increasing amounts of a fusion protein consisting of the extracellular domain of TRAILshort fused to Fc (TRAILshort-ECD:Fc) or with BSA control and analyzed as in (A). Additional control cells were treated with increasing TRAILshort-ECD:Fc alone. Data are representative of six independent experiments. p < 0.05 considered statistically significant (linear regression).
Original language | English (US) |
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Pages (from-to) | 1599 |
Number of pages | 1 |
Journal | Journal of Immunology |
Volume | 201 |
Issue number | 5 |
DOIs |
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State | Published - Sep 1 2018 |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology