Corrections: Both HIV-infected and uninfected cells express TRAILshort, which confers TRAIL resistance upon bystander cells within the microenvironment (Journal of Immunology (2008) 200 (1110-1123) DOI: 10.4049/jimmunol.1701113)

Zilin Nie, Fatma Aboulnasr, Sekar Natesampillai, Stephen P. Burke, Ashton Krogman, Gary D. Bren, Thomas D.Y. Chung, Jeff R. Anderson, Michele K. Smart, David J Katzmann, Govindarajan Rajagopalan, Nathan W Cummins, Andrew David Badley

Research output: Contribution to journalComment/debate

1 Scopus citations

Abstract

FIGURE 6. TRAILshort is both necessary and sufficient to cause TRAIL resistance. (A) Jurkat T cells, which constitutively express TRAILshort, were induced to die by the addition of sk-TRAIL, in the presence or absence of increasing amounts of anti-TRAILshort Ab. Cell death was measured by active caspase-3 staining. Control cells were treated with increasing anti-TRAILshort Ab alone. (B) HeLa cells, which do not express TRAILshort, were stimulated to die by the addition of sk-TRAIL in the absence or presence of increasing amounts of a fusion protein consisting of the extracellular domain of TRAILshort fused to Fc (TRAILshort-ECD:Fc) or with BSA control and analyzed as in (A). Additional control cells were treated with increasing TRAILshort-ECD:Fc alone. Data are representative of six independent experiments. p < 0.05 considered statistically significant (linear regression).

Original languageEnglish (US)
Number of pages1
JournalJournal of Immunology
Volume201
Issue number5
DOIs
StatePublished - Feb 1 2018

ASJC Scopus subject areas

  • Immunology

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