TY - JOUR
T1 - Correction to
T2 - Kidney and lung crosstalk during critical illness: large-scale cohort study (Journal of Nephrology, (2023), 36, 4, (1037-1046), 10.1007/s40620-022-01558-9)
AU - Tomasi, Alessandra
AU - Song, Xuan
AU - Gajic, Ognjen
AU - Kashani, Kianoush
N1 - Publisher Copyright:
© 2023, The Author(s) under exclusive licence to Italian Society of Nephrology.
PY - 2023/5
Y1 - 2023/5
N2 - The following discrepancies were noted between the published article and the actual final iteration of revisions provided by the authors for the journal: Fig. 2A, the error bar is missing. The updated figures are copied below. (Figure presented.) Tables 1, 2, 3, 4, and 5 are all missing pair-wise comparisons. These pairwise comparisons were specifically requested as the final revision for acceptance of the manuscript, and were completed and included by the authors in the final revision draft. Unfortunately, the tables included in the published manuscript do not include any of these pair-wise comparisons. Additionally, we note errors in Table 4, which does not include ICU duration with IQR, however does still include the p values associated with this data point, thereby resulting in completely mis-aligned and incorrect p values as well as missing data (the p value of 0.004 corresponds to hospital mortality, 0.009 to ICU mortality, 0.862 to ICU duration (which was erroneously deleted from this table between revision and publication), and 0.194 to hospital duration). Below are the correct versions of the Tables. (Table presented.) (Table presented.) (Table presented.) (Table presented.) (Table presented.) Fig. 2A, the error bar is missing. The updated figures are copied below. Tables 1, 2, 3, 4, and 5 are all missing pair-wise comparisons. These pairwise comparisons were specifically requested as the final revision for acceptance of the manuscript, and were completed and included by the authors in the final revision draft. Unfortunately, the tables included in the published manuscript do not include any of these pair-wise comparisons. Additionally, we note errors in Table 4, which does not include ICU duration with IQR, however does still include the p values associated with this data point, thereby resulting in completely mis-aligned and incorrect p values as well as missing data (the p value of 0.004 corresponds to hospital mortality, 0.009 to ICU mortality, 0.862 to ICU duration (which was erroneously deleted from this table between revision and publication), and 0.194 to hospital duration). Below are the correct versions of the Tables. (Table presented.) (Table presented.) (Table presented.) (Table presented.) (Table presented.) Baseline characteristics No ARDS/AKI N = 47,043 (0) ARDS alone N = 491 (1) AKI alone N = 27,928 (2) ARDS with AKI N = 1526 (3) p values Overall 0 vs 1 0 vs 2 0 vs 3 1 vs 2 1 vs 3 2 vs 3 Age, mean (SD) 61 (17.75) 59 (17.59) 65 (16.38) 62 (16.15) < 0.001 NS < 0.001 < 0.001 < 0.001 0.005 < 0.001 Male, n (%) 26,957 (57.3%) 278 (56.6%) 16,370 (58.6%) 860 (56.4%) 0.003 NS < 0.001 NS 0.001 0.03 NS White, n (%) 42,102 (89.5%) 437 (89.0%) 24,962 (89.4%) 1,344 (88.1%) 0.001 NS NS NS < 0.001 0.01 0.003 CCI, mean (SD) 3.69 (2.37) 3.76 (2.29) 4.60 (2.42) 4.27 (2.34) < 0.001 NS < 0.001 < 0.001 < 0.001 < 0.001 < 0.001 Initial SOFA score, mean (SD) 3.26 (2.79) 6.13 (3.10) 5.79 (3.56) 8.82 (4.02) < 0.001 NS < 0.001 < 0.001 0.02 < 0.001 < 0.001 APACHE score, mean (SD) 36.31 (18.82) 48.08 (22.01) 46.03 (21.05) 53.95 (24.02) < 0.001 < 0.001 < 0.001 < 0.001 0.02 < 0.001 < 0.001 ARDS acute respiratory distress syndrome, AKI acute kidney injury, APACHE Acute Physiologic Assessment, and Chronic Health Evaluation, SOFA Sequential Organ Failure Assessment, CCI Charlson Comorbidity Index Characteristics and outcomes by the timing of AKI and ARDS onset AKI before ARDS, > 1 day (1) ARDS before AKI, > 1 day (2) AKI and ARDS within 1 day (3) p value: overall p value: 1 vs 2 p value: 1 vs 3 p value: 2 vs 3 Charlson score, mean (SD) 4.76 (2.26) 3.87 (2.41) 4.56 (2.35) < 0.001 < 0.001 NS < 0.001 Initial SOFA score, mean (SD) 8.76 (4.61) 7.25 (2.88) 10.03 (3.94) < 0.001 < 0.001 0.001 < 0.001 Initial APACHE score, mean (SD) 52.15 (22.19) 50.98 (22.61) 57.86 (24.78) 0.002 NS 0.033 < 0.001 ICU mortality, n (%) 40 (29.4%) 42 (13.9%) 180 (25.8%) < 0.001 0.001 0.04 < 0.001 Hospital mortality, n (%) 50 (36.8%) 65 (21.5%) 222 (31.9%) < 0.001 0.007 0.02 0.008 ICU duration, median (IQR) 7.8 (4.8, 11.2) 7.5 (4.3, 12.5) 5.2 (2.8, 8.9) 0.001 NS < 0.001 < 0.001 Hospital duration, median (IQR) 17.3 (10.1, 30.3) 13.9 (8.8, 24.1) 10.9 (6.0, 19.8) 0.001 NS < 0.001 0.0049 Sepsis present, n (%) 122 (89.7%) 248 (81.8%) 965 (84.9%) 0.09 NS NS NS ARDS acute respiratory distress syndrome, AKI acute kidney injury, APACHE Acute Physiologic Assessment, and Chronic Health Evaluation, SOFA Sequential Organ Failure Assessment, ICU intensive care unit Hospital and ICU outcomes for patients with ARDS, AKI, or ARDS and AKI No ARDS/AKI N = 47,043 (0) ARDS alone N = 491 (1) AKI alone N = 27,928 (2) ARDS with AKI N = 1526 (3) p values Overall 0 vs 1 0 vs 2 0 vs 3 1 vs 2 1 vs 3 2 vs 3 Renal replacement therapy, n (%) 72 (0.15%) 3 (0.61%) 2,579 (9.20%) 338 (22.15%) < 0.001 0.04 < 0.001 < 0.001 < 0.001 < 0.001 < 0.001 ICU mortality, n (%) 398 (0.87%) 44 (9.0%) 1,179 (4.4%) 324 (21.2%) < 0.001 < 0.001 < 0.001 < 0.001 < 0.001 < 0.001 < 0.001 Hospital mortality, n (%) 973 (2.1%) 69 (14.0%) 2,301 (8.5%) 433 (28.4%) < 0.001 < 0.001 < 0.001 < 0.001 < 0.001 0.001 < 0.001 ICU duration, median (IQR) 0.9 (0.8, 1.3) 2.5 (1.2, 4.8) 1.9 (1.1, 3.8) 5.9 (2.9, 10.9) < 0.001 < 0.001 < 0.001 < 0.001 NS < 0.001 < 0.001 Hospital duration, median (IQR) 4.3 (2.6, 6.9) 7.7 (4.7, 13.4) 7.3 (4.8, 12.6) 13.7 (7.4, 23.6) < 0.001 < 0.001 < 0.001 < 0.001 NS < 0.001 < 0.001 ARDS acute respiratory distress syndrome, AKI acute kidney injury, ICU intensive care unit Characteristics and outcomes by ARDS severity in patients with both AKI and ARDS Mild ARDS (1) Moderate ARDS (2) Severe ARDS (3) p value overall p value 1 vs 2 p value 1 vs 3 p value 2 vs 3 Age, mean (SD) 63 (16.52) 64 (15.54) 61 (16.33) 0.013 NS NS 0.011 Sex 0.618 NS NS NS Female, n (%) 128 (42.8%) 242 (43.8%) 133 (46.7%) Male, n (%) 171 (57.2%) 310 (56.2%) 152 (53.3%) SOFA score, mean (SD) 9.07 (3.86) 9.08 (3.92) 9.32 (4.15) 0.661 NS NS NS APACHE III score, mean (SD) 54.37 (22.19) 56.41 (25.44) 54.29 (23.39) 0.352 NS NS NS AKI stage, n (%) 0.267 NS NS NS 1 114 (38.1%) 211 (38.2%) 103 (36.1%) 2 74 (24.7) 104 (18.8%) 63 (22.1%) 3 111 (37.1%) 237 (42.9%) 119 (41.8%) Hospital mortality, n (%) 64 (21.4%) 179 (30.8%) 103 (36.1%) 0.0004 0.003 < 0.001 NS ICU mortality, n (%) 53 (17.7%) 128 (23.1%) 81 (28.4%) 0.009 0.005 < 0.001 0.02 ICU duration, median (IQR) 5.5 (2.9, 10.0) 5.9 (3.0, 10.2) 5.5 (3.3, 9.7) 0.862 NS NS NS Hospital duration, median (IQR) 12.4 (6.9, 23.0) 12.7 (6.7, 21.7) 11.1 (5.9, 20.4) 0.195 NS NS NS ARDS acute respiratory distress syndrome, AKI acute kidney injury, APACHE Acute Physiologic Assessment, and Chronic Health Evaluation, SOFA Sequential Organ Failure Assessment, ICU intensive care unit Characteristics and outcomes by AKI stage in patients with both AKI and ARDS Variable Stage 1 AKI (1) Stage 2 AKI (2) Stage 3 AKI (3) p value overall p value 1 vs 2 p value 1 vs 3 p value 2 vs 3 Age, mean (SD) 62 (16.31) 66 (15.80) 60 (15.79) < 0.001 < 0.001 NS < 0.001 Sex 0.107 NS NS NS Female, n (%) 238 (40.7%) 138 (43.1%) 290 (46.7%) Male, n (%) 347 (59.3%) 182 (56.9%) 331 (53.3%) SOFA score, mean (SD) 7.36 (3.17) 8.78 (3.83) 10.21 (4.34) < 0.001 < 0.001 < 0.001 < 0.001 APACHE III score 51.49 (21.12) 56.24 (26.72) 55.09 (24.94) 0.0054 0.0134 0.0275 NS ARDS severity, n (%) 0.267 NS NS NS Mild 114 (26.6%) 74 (30.7%) 111 (23.8%) Moderate 211 (42.3%) 104 (43.2%) 237 (50.7%) Severe 103 (24.1%) 63 (26.1%) 119 (25.5%) Hospital mortality, (%) 116 (19.8%) 90 (28.1%) 227 (36.6%) < 0.001 0.02 < 0.001 0.01 ICU mortality, (%) 78 (13.3%) 72 (22.5%) 174 (28.0%) < 0.001 0.02 < 0.001 0.02 ICU duration, median (IQR) 4.7 (2.6, 7.9) 5.5 (3.2, 9.9) 8.9 (5.6, 14.7) < 0.001 NS < 0.001 < 0.001 Hospital duration, median (IQR) 10.4 (6.1, 17.3) 11.2 (6.4, 20.4) 17.4 (9.6, 29.0) < 0.001 NS < 0.001 < 0.001 ARDS acute respiratory distress syndrome, AKI acute kidney injury, APACHE Acute Physiologic Assessment, and Chronic Health Evaluation, SOFA Sequential Organ Failure Assessment, ICU intensive care unit The original article has been corrected.
AB - The following discrepancies were noted between the published article and the actual final iteration of revisions provided by the authors for the journal: Fig. 2A, the error bar is missing. The updated figures are copied below. (Figure presented.) Tables 1, 2, 3, 4, and 5 are all missing pair-wise comparisons. These pairwise comparisons were specifically requested as the final revision for acceptance of the manuscript, and were completed and included by the authors in the final revision draft. Unfortunately, the tables included in the published manuscript do not include any of these pair-wise comparisons. Additionally, we note errors in Table 4, which does not include ICU duration with IQR, however does still include the p values associated with this data point, thereby resulting in completely mis-aligned and incorrect p values as well as missing data (the p value of 0.004 corresponds to hospital mortality, 0.009 to ICU mortality, 0.862 to ICU duration (which was erroneously deleted from this table between revision and publication), and 0.194 to hospital duration). Below are the correct versions of the Tables. (Table presented.) (Table presented.) (Table presented.) (Table presented.) (Table presented.) Fig. 2A, the error bar is missing. The updated figures are copied below. Tables 1, 2, 3, 4, and 5 are all missing pair-wise comparisons. These pairwise comparisons were specifically requested as the final revision for acceptance of the manuscript, and were completed and included by the authors in the final revision draft. Unfortunately, the tables included in the published manuscript do not include any of these pair-wise comparisons. Additionally, we note errors in Table 4, which does not include ICU duration with IQR, however does still include the p values associated with this data point, thereby resulting in completely mis-aligned and incorrect p values as well as missing data (the p value of 0.004 corresponds to hospital mortality, 0.009 to ICU mortality, 0.862 to ICU duration (which was erroneously deleted from this table between revision and publication), and 0.194 to hospital duration). Below are the correct versions of the Tables. (Table presented.) (Table presented.) (Table presented.) (Table presented.) (Table presented.) Baseline characteristics No ARDS/AKI N = 47,043 (0) ARDS alone N = 491 (1) AKI alone N = 27,928 (2) ARDS with AKI N = 1526 (3) p values Overall 0 vs 1 0 vs 2 0 vs 3 1 vs 2 1 vs 3 2 vs 3 Age, mean (SD) 61 (17.75) 59 (17.59) 65 (16.38) 62 (16.15) < 0.001 NS < 0.001 < 0.001 < 0.001 0.005 < 0.001 Male, n (%) 26,957 (57.3%) 278 (56.6%) 16,370 (58.6%) 860 (56.4%) 0.003 NS < 0.001 NS 0.001 0.03 NS White, n (%) 42,102 (89.5%) 437 (89.0%) 24,962 (89.4%) 1,344 (88.1%) 0.001 NS NS NS < 0.001 0.01 0.003 CCI, mean (SD) 3.69 (2.37) 3.76 (2.29) 4.60 (2.42) 4.27 (2.34) < 0.001 NS < 0.001 < 0.001 < 0.001 < 0.001 < 0.001 Initial SOFA score, mean (SD) 3.26 (2.79) 6.13 (3.10) 5.79 (3.56) 8.82 (4.02) < 0.001 NS < 0.001 < 0.001 0.02 < 0.001 < 0.001 APACHE score, mean (SD) 36.31 (18.82) 48.08 (22.01) 46.03 (21.05) 53.95 (24.02) < 0.001 < 0.001 < 0.001 < 0.001 0.02 < 0.001 < 0.001 ARDS acute respiratory distress syndrome, AKI acute kidney injury, APACHE Acute Physiologic Assessment, and Chronic Health Evaluation, SOFA Sequential Organ Failure Assessment, CCI Charlson Comorbidity Index Characteristics and outcomes by the timing of AKI and ARDS onset AKI before ARDS, > 1 day (1) ARDS before AKI, > 1 day (2) AKI and ARDS within 1 day (3) p value: overall p value: 1 vs 2 p value: 1 vs 3 p value: 2 vs 3 Charlson score, mean (SD) 4.76 (2.26) 3.87 (2.41) 4.56 (2.35) < 0.001 < 0.001 NS < 0.001 Initial SOFA score, mean (SD) 8.76 (4.61) 7.25 (2.88) 10.03 (3.94) < 0.001 < 0.001 0.001 < 0.001 Initial APACHE score, mean (SD) 52.15 (22.19) 50.98 (22.61) 57.86 (24.78) 0.002 NS 0.033 < 0.001 ICU mortality, n (%) 40 (29.4%) 42 (13.9%) 180 (25.8%) < 0.001 0.001 0.04 < 0.001 Hospital mortality, n (%) 50 (36.8%) 65 (21.5%) 222 (31.9%) < 0.001 0.007 0.02 0.008 ICU duration, median (IQR) 7.8 (4.8, 11.2) 7.5 (4.3, 12.5) 5.2 (2.8, 8.9) 0.001 NS < 0.001 < 0.001 Hospital duration, median (IQR) 17.3 (10.1, 30.3) 13.9 (8.8, 24.1) 10.9 (6.0, 19.8) 0.001 NS < 0.001 0.0049 Sepsis present, n (%) 122 (89.7%) 248 (81.8%) 965 (84.9%) 0.09 NS NS NS ARDS acute respiratory distress syndrome, AKI acute kidney injury, APACHE Acute Physiologic Assessment, and Chronic Health Evaluation, SOFA Sequential Organ Failure Assessment, ICU intensive care unit Hospital and ICU outcomes for patients with ARDS, AKI, or ARDS and AKI No ARDS/AKI N = 47,043 (0) ARDS alone N = 491 (1) AKI alone N = 27,928 (2) ARDS with AKI N = 1526 (3) p values Overall 0 vs 1 0 vs 2 0 vs 3 1 vs 2 1 vs 3 2 vs 3 Renal replacement therapy, n (%) 72 (0.15%) 3 (0.61%) 2,579 (9.20%) 338 (22.15%) < 0.001 0.04 < 0.001 < 0.001 < 0.001 < 0.001 < 0.001 ICU mortality, n (%) 398 (0.87%) 44 (9.0%) 1,179 (4.4%) 324 (21.2%) < 0.001 < 0.001 < 0.001 < 0.001 < 0.001 < 0.001 < 0.001 Hospital mortality, n (%) 973 (2.1%) 69 (14.0%) 2,301 (8.5%) 433 (28.4%) < 0.001 < 0.001 < 0.001 < 0.001 < 0.001 0.001 < 0.001 ICU duration, median (IQR) 0.9 (0.8, 1.3) 2.5 (1.2, 4.8) 1.9 (1.1, 3.8) 5.9 (2.9, 10.9) < 0.001 < 0.001 < 0.001 < 0.001 NS < 0.001 < 0.001 Hospital duration, median (IQR) 4.3 (2.6, 6.9) 7.7 (4.7, 13.4) 7.3 (4.8, 12.6) 13.7 (7.4, 23.6) < 0.001 < 0.001 < 0.001 < 0.001 NS < 0.001 < 0.001 ARDS acute respiratory distress syndrome, AKI acute kidney injury, ICU intensive care unit Characteristics and outcomes by ARDS severity in patients with both AKI and ARDS Mild ARDS (1) Moderate ARDS (2) Severe ARDS (3) p value overall p value 1 vs 2 p value 1 vs 3 p value 2 vs 3 Age, mean (SD) 63 (16.52) 64 (15.54) 61 (16.33) 0.013 NS NS 0.011 Sex 0.618 NS NS NS Female, n (%) 128 (42.8%) 242 (43.8%) 133 (46.7%) Male, n (%) 171 (57.2%) 310 (56.2%) 152 (53.3%) SOFA score, mean (SD) 9.07 (3.86) 9.08 (3.92) 9.32 (4.15) 0.661 NS NS NS APACHE III score, mean (SD) 54.37 (22.19) 56.41 (25.44) 54.29 (23.39) 0.352 NS NS NS AKI stage, n (%) 0.267 NS NS NS 1 114 (38.1%) 211 (38.2%) 103 (36.1%) 2 74 (24.7) 104 (18.8%) 63 (22.1%) 3 111 (37.1%) 237 (42.9%) 119 (41.8%) Hospital mortality, n (%) 64 (21.4%) 179 (30.8%) 103 (36.1%) 0.0004 0.003 < 0.001 NS ICU mortality, n (%) 53 (17.7%) 128 (23.1%) 81 (28.4%) 0.009 0.005 < 0.001 0.02 ICU duration, median (IQR) 5.5 (2.9, 10.0) 5.9 (3.0, 10.2) 5.5 (3.3, 9.7) 0.862 NS NS NS Hospital duration, median (IQR) 12.4 (6.9, 23.0) 12.7 (6.7, 21.7) 11.1 (5.9, 20.4) 0.195 NS NS NS ARDS acute respiratory distress syndrome, AKI acute kidney injury, APACHE Acute Physiologic Assessment, and Chronic Health Evaluation, SOFA Sequential Organ Failure Assessment, ICU intensive care unit Characteristics and outcomes by AKI stage in patients with both AKI and ARDS Variable Stage 1 AKI (1) Stage 2 AKI (2) Stage 3 AKI (3) p value overall p value 1 vs 2 p value 1 vs 3 p value 2 vs 3 Age, mean (SD) 62 (16.31) 66 (15.80) 60 (15.79) < 0.001 < 0.001 NS < 0.001 Sex 0.107 NS NS NS Female, n (%) 238 (40.7%) 138 (43.1%) 290 (46.7%) Male, n (%) 347 (59.3%) 182 (56.9%) 331 (53.3%) SOFA score, mean (SD) 7.36 (3.17) 8.78 (3.83) 10.21 (4.34) < 0.001 < 0.001 < 0.001 < 0.001 APACHE III score 51.49 (21.12) 56.24 (26.72) 55.09 (24.94) 0.0054 0.0134 0.0275 NS ARDS severity, n (%) 0.267 NS NS NS Mild 114 (26.6%) 74 (30.7%) 111 (23.8%) Moderate 211 (42.3%) 104 (43.2%) 237 (50.7%) Severe 103 (24.1%) 63 (26.1%) 119 (25.5%) Hospital mortality, (%) 116 (19.8%) 90 (28.1%) 227 (36.6%) < 0.001 0.02 < 0.001 0.01 ICU mortality, (%) 78 (13.3%) 72 (22.5%) 174 (28.0%) < 0.001 0.02 < 0.001 0.02 ICU duration, median (IQR) 4.7 (2.6, 7.9) 5.5 (3.2, 9.9) 8.9 (5.6, 14.7) < 0.001 NS < 0.001 < 0.001 Hospital duration, median (IQR) 10.4 (6.1, 17.3) 11.2 (6.4, 20.4) 17.4 (9.6, 29.0) < 0.001 NS < 0.001 < 0.001 ARDS acute respiratory distress syndrome, AKI acute kidney injury, APACHE Acute Physiologic Assessment, and Chronic Health Evaluation, SOFA Sequential Organ Failure Assessment, ICU intensive care unit The original article has been corrected.
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U2 - 10.1007/s40620-023-01594-z
DO - 10.1007/s40620-023-01594-z
M3 - Comment/debate
C2 - 36759395
AN - SCOPUS:85147780375
SN - 1121-8428
VL - 36
SP - 1213
EP - 1217
JO - Journal of Nephrology
JF - Journal of Nephrology
IS - 4
ER -