Correction of microtubule-kinetochore attachment errors: Mechanisms and role in tumor suppression

Robin M. Ricke, Jan M. Van Deursen

Research output: Contribution to journalReview article

9 Scopus citations

Abstract

During mitosis, cells segregate duplicated chromosomes with high fidelity in order to maintain genome stability. Proper attachment of sister kinetochores to spindle microtubules is critical for accurate chromosome segregation and is driven by complex mechanisms that promote the capture of unattached kinetochores and the resolution of erroneously attached kinetochores. Defects in these surveillance systems promote chromosome segregation and aneuploidy and can contribute to neoplastic transformation. Understanding, how, at the molecular level, accurate chromosome segregation is achieved may be crucial for our understanding of how cancer cells develop genome instability.

Original languageEnglish (US)
Pages (from-to)559-565
Number of pages7
JournalSeminars in Cell and Developmental Biology
Volume22
Issue number6
DOIs
StatePublished - Aug 2011

Keywords

  • APC/C
  • Aurora b
  • Chromosome passenger complex (CPC)
  • Microtubule-kinetochore attachment
  • Mitotic checkpoint

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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