Correction of factor XI deficiency by liver transplantation

Eva Gupta, Laura Finn, Gretchen Johns, Rajiv K. Pruthi, Vivek Roy

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Orthotopic liver transplantation for other diseases typically results in a coincidental cure for hemophilia A and B; however, long-term outcomes of liver transplant in hemophilia C are not very well described. Herein, the authors report a patient of severe congenital factor XI (FXI) deficiency who received an orthotopic liver transplant. The authors discuss the perioperative management and long-term outcomes. The normalization of his FXI levels confirms that the liver is the most clinically relevant site of synthesis of FXI.

Original languageEnglish (US)
Pages (from-to)961-963
Number of pages3
JournalBlood Coagulation and Fibrinolysis
Volume26
Issue number8
DOIs
StatePublished - 2015
Externally publishedYes

Fingerprint

Factor XI Deficiency
Factor XI
Liver Transplantation
Liver
Transplants
Hemophilia B
Hemophilia A

Keywords

  • Bleeding
  • Clotting factors
  • Factor XI deficiency
  • Hemophilia
  • Liver transplant

ASJC Scopus subject areas

  • Hematology

Cite this

Correction of factor XI deficiency by liver transplantation. / Gupta, Eva; Finn, Laura; Johns, Gretchen; Pruthi, Rajiv K.; Roy, Vivek.

In: Blood Coagulation and Fibrinolysis, Vol. 26, No. 8, 2015, p. 961-963.

Research output: Contribution to journalArticle

Gupta, Eva ; Finn, Laura ; Johns, Gretchen ; Pruthi, Rajiv K. ; Roy, Vivek. / Correction of factor XI deficiency by liver transplantation. In: Blood Coagulation and Fibrinolysis. 2015 ; Vol. 26, No. 8. pp. 961-963.
@article{b600e2ebb3c34cd29deacea63f42b5c4,
title = "Correction of factor XI deficiency by liver transplantation",
abstract = "Orthotopic liver transplantation for other diseases typically results in a coincidental cure for hemophilia A and B; however, long-term outcomes of liver transplant in hemophilia C are not very well described. Herein, the authors report a patient of severe congenital factor XI (FXI) deficiency who received an orthotopic liver transplant. The authors discuss the perioperative management and long-term outcomes. The normalization of his FXI levels confirms that the liver is the most clinically relevant site of synthesis of FXI.",
keywords = "Bleeding, Clotting factors, Factor XI deficiency, Hemophilia, Liver transplant",
author = "Eva Gupta and Laura Finn and Gretchen Johns and Pruthi, {Rajiv K.} and Vivek Roy",
year = "2015",
doi = "10.1097/MBC.0000000000000344",
language = "English (US)",
volume = "26",
pages = "961--963",
journal = "Blood Coagulation and Fibrinolysis",
issn = "0957-5235",
publisher = "Lippincott Williams and Wilkins",
number = "8",

}

TY - JOUR

T1 - Correction of factor XI deficiency by liver transplantation

AU - Gupta, Eva

AU - Finn, Laura

AU - Johns, Gretchen

AU - Pruthi, Rajiv K.

AU - Roy, Vivek

PY - 2015

Y1 - 2015

N2 - Orthotopic liver transplantation for other diseases typically results in a coincidental cure for hemophilia A and B; however, long-term outcomes of liver transplant in hemophilia C are not very well described. Herein, the authors report a patient of severe congenital factor XI (FXI) deficiency who received an orthotopic liver transplant. The authors discuss the perioperative management and long-term outcomes. The normalization of his FXI levels confirms that the liver is the most clinically relevant site of synthesis of FXI.

AB - Orthotopic liver transplantation for other diseases typically results in a coincidental cure for hemophilia A and B; however, long-term outcomes of liver transplant in hemophilia C are not very well described. Herein, the authors report a patient of severe congenital factor XI (FXI) deficiency who received an orthotopic liver transplant. The authors discuss the perioperative management and long-term outcomes. The normalization of his FXI levels confirms that the liver is the most clinically relevant site of synthesis of FXI.

KW - Bleeding

KW - Clotting factors

KW - Factor XI deficiency

KW - Hemophilia

KW - Liver transplant

UR - http://www.scopus.com/inward/record.url?scp=84947072703&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84947072703&partnerID=8YFLogxK

U2 - 10.1097/MBC.0000000000000344

DO - 10.1097/MBC.0000000000000344

M3 - Article

C2 - 26196192

AN - SCOPUS:84947072703

VL - 26

SP - 961

EP - 963

JO - Blood Coagulation and Fibrinolysis

JF - Blood Coagulation and Fibrinolysis

SN - 0957-5235

IS - 8

ER -