Correction for attenuation in technetium-99m-HMPAO SPECT brain imaging

B. J. Kemp, F. S. Prato, G. W. Dean, R. L. Nicholson, L. Reese

Research output: Contribution to journalArticle

19 Scopus citations


We present a correction technique that uses the effective bone and tissue attenuation coefficients to compensate 99mTc-HMPAO brain SPECT projections for attenuation. Transverse images of a human skull filled with a uniform mixture of 99mTc and gelatin have a greater count density at the center with respect to the periphery when corrected for attenuation with the effective water/tissue coefficient of 0.12 cm-1. An attenuation coefficient of 0.09 cm-1 produces uniform images at the expense of a reduced count density. Additional experiments with phantoms wrapped with aluminum (to simulate bone) indicate that the greater count density at the image center is a result of increased attenuation at the edges of the projections where there is a greater path length through the aluminum (or bone). SPECT projections explicitly corrected for both bone and soft-tissue attenuation result in images of improved uniformity and increased count density.

Original languageEnglish (US)
Pages (from-to)1875-1880
Number of pages6
JournalJournal of Nuclear Medicine
Issue number10
StatePublished - Jan 1 1992

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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    Kemp, B. J., Prato, F. S., Dean, G. W., Nicholson, R. L., & Reese, L. (1992). Correction for attenuation in technetium-99m-HMPAO SPECT brain imaging. Journal of Nuclear Medicine, 33(10), 1875-1880.