Correction for attenuation in technetium-99m-HMPAO SPECT brain imaging

B. J. Kemp, F. S. Prato, G. W. Dean, R. L. Nicholson, L. Reese

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

We present a correction technique that uses the effective bone and tissue attenuation coefficients to compensate 99mTc-HMPAO brain SPECT projections for attenuation. Transverse images of a human skull filled with a uniform mixture of 99mTc and gelatin have a greater count density at the center with respect to the periphery when corrected for attenuation with the effective water/tissue coefficient of 0.12 cm-1. An attenuation coefficient of 0.09 cm-1 produces uniform images at the expense of a reduced count density. Additional experiments with phantoms wrapped with aluminum (to simulate bone) indicate that the greater count density at the image center is a result of increased attenuation at the edges of the projections where there is a greater path length through the aluminum (or bone). SPECT projections explicitly corrected for both bone and soft-tissue attenuation result in images of improved uniformity and increased count density.

Original languageEnglish (US)
Pages (from-to)1875-1880
Number of pages6
JournalJournal of Nuclear Medicine
Volume33
Issue number10
StatePublished - 1992
Externally publishedYes

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Technetium
Single-Photon Emission-Computed Tomography
Neuroimaging
Bone and Bones
Aluminum
Technetium Tc 99m Exametazime
Gelatin
Skull
Water
Brain

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Kemp, B. J., Prato, F. S., Dean, G. W., Nicholson, R. L., & Reese, L. (1992). Correction for attenuation in technetium-99m-HMPAO SPECT brain imaging. Journal of Nuclear Medicine, 33(10), 1875-1880.

Correction for attenuation in technetium-99m-HMPAO SPECT brain imaging. / Kemp, B. J.; Prato, F. S.; Dean, G. W.; Nicholson, R. L.; Reese, L.

In: Journal of Nuclear Medicine, Vol. 33, No. 10, 1992, p. 1875-1880.

Research output: Contribution to journalArticle

Kemp, BJ, Prato, FS, Dean, GW, Nicholson, RL & Reese, L 1992, 'Correction for attenuation in technetium-99m-HMPAO SPECT brain imaging', Journal of Nuclear Medicine, vol. 33, no. 10, pp. 1875-1880.
Kemp BJ, Prato FS, Dean GW, Nicholson RL, Reese L. Correction for attenuation in technetium-99m-HMPAO SPECT brain imaging. Journal of Nuclear Medicine. 1992;33(10):1875-1880.
Kemp, B. J. ; Prato, F. S. ; Dean, G. W. ; Nicholson, R. L. ; Reese, L. / Correction for attenuation in technetium-99m-HMPAO SPECT brain imaging. In: Journal of Nuclear Medicine. 1992 ; Vol. 33, No. 10. pp. 1875-1880.
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