Abstract
Background: Data on corpus callosum involvement in myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) are limited. Objective: The objective of the study was to compare callosal lesions in MOGAD, multiple sclerosis (MS), and aquaporin-4-IgG positive neuromyelitis optica spectrum disorder (AQP4+NMOSD). Results: Callosal lesion frequency was similar in MOGAD (38/171 (22%)), MS (24/72 (33%)), and AQP4+NMOSD (18/63 (29%)). Clinical phenotypes included encephalopathy (47%) and focal supratentorial (21%) or infratentorial (45%) deficits. None had callosal-disconnection syndromes. Maximal callosal-T2-lesion diameter (median (range)) in millimeter was similar in MOGAD (21 (4–77)) and AQP4+NMOSD (22 (5–49); p = 0.93) but greater than in MS (10.5 (2–64)). Extracallosal extension (21/38 (55%)) and T2-lesion resolution (19/34 (56%)) favored MOGAD. Conclusions: Despite similar frequency and imaging overlap, larger lesions, sagittal midline involvement, and lesion resolution favored MOGAD.
Original language | English (US) |
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Pages (from-to) | 748-752 |
Number of pages | 5 |
Journal | Multiple Sclerosis Journal |
Volume | 29 |
Issue number | 6 |
DOIs | |
State | Published - May 2023 |
Keywords
- Myelin oligodendrocyte glycoprotein
- aquaporin 4
- corpus callosum
- magnetic resonance imaging
- multiple sclerosis
- neuromyelitis optica
ASJC Scopus subject areas
- Neurology
- Clinical Neurology