Coronavirus Disease 2019 and the Cerebrovascular-Cardiovascular Systems: What Do We Know So Far?

Anthony S. Larson, Luis Savastano, Ramanathan D Kadirvel, David F. Kallmes, Ameer E. Hassan, Waleed Brinjikji

Research output: Contribution to journalReview article

3 Scopus citations

Abstract

The severe acute respiratory syndrome coronavirus 2 pandemic of 2019 to 2020 has resulted in multiple hospitalizations, deaths, and economic hardships worldwide. Although respiratory involvement in patients with coronavirus disease 2019 (COVID-19) is well known, the potential cardiovascular and cerebrovascular manifestations are less understood. We performed a PubMed and Google Scholar search and reviewed relevant literature on COVID-19 and cardiovascular system involvement. Severe acute respiratory syndrome coronavirus 2 possesses high affinity for angiotensin-converting enzyme 2 receptor, which is highly concentrated in the lungs and cardiovascular tissue, thereby provoking concern for cardiovascular involvement in COVID-19 cases. Preexisting cardiovascular and cerebrovascular disease has been shown in previous reports to be a risk factor for severe infection. On the basis of our review of published studies, COVID-19 patients may be more likely to experience acute cardiac injury, arrhythmia, coagulation defects, and acute stroke and are likely to have poorer outcomes as a result. As the COVID-19 pandemic continues, more data about potential cardiovascular and cerebrovascular manifestations of the disease are required.

Original languageEnglish (US)
Pages (from-to)e016793
JournalJournal of the American Heart Association
Volume9
Issue number13
DOIs
StatePublished - Jul 7 2020

Keywords

  • cardiac disease
  • cerebrovascular disease/stroke
  • coronavirus
  • COVID‐19
  • SARS‐CoV‐2
  • vascular disease

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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