Coronary sarcoidosis presenting as acute coronary syndrome

Carolyn S P Lam, Kenneth A. Tolep, Michael P. Metke, James Glockner, Leslie T Jr. Cooper

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Sarcoidosis is a systemic disorder of uncertain etiology characterized by noncaseating granulomatous inflammation. The disease often involves the heart on autopsy, but the antemortem diagnosis of cardiac sarcoidosis is frequently missed. Cardiac involvement usually includes granulomatous inflammation or fibrosis of the myocardium, conduction system, or pericardium. We now describe a case of epicardial coronary involvement by sarcoidosis, where the diagnosis was made by surgical biopsy of the coronary artery in an African American man presenting with acute coronary syndrome and recurrent symptomatic restenosis following coronary intervention. The case extends the spectrum of common cardiac syndromes that cardiac sarcoidosis can masquerade as and highlights the importance of maintaining a high index of suspicion for early recognition and instituting specific treatment that might improve prognosis. A review of the literature also suggests the need for improvement in diagnostic approaches and prospective clinical trials to establish the best management strategy for this disease.

Original languageEnglish (US)
JournalClinical Cardiology
Volume32
Issue number6
DOIs
StatePublished - Jun 2009

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Acute Coronary Syndrome
Sarcoidosis
Coronary Restenosis
Inflammation
Pericardium
Disease Management
African Americans
Autopsy
Coronary Vessels
Myocardium
Fibrosis
Clinical Trials
Biopsy
Therapeutics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Coronary sarcoidosis presenting as acute coronary syndrome. / Lam, Carolyn S P; Tolep, Kenneth A.; Metke, Michael P.; Glockner, James; Cooper, Leslie T Jr.

In: Clinical Cardiology, Vol. 32, No. 6, 06.2009.

Research output: Contribution to journalArticle

Lam, Carolyn S P ; Tolep, Kenneth A. ; Metke, Michael P. ; Glockner, James ; Cooper, Leslie T Jr. / Coronary sarcoidosis presenting as acute coronary syndrome. In: Clinical Cardiology. 2009 ; Vol. 32, No. 6.
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