TY - JOUR
T1 - Coronary interventions before liver transplantation
T2 - Might not avert postoperative cardiovascular events
AU - Snipelisky, David F.
AU - McRee, Chad
AU - Seeger, Kristina
AU - Levy, Michael
AU - Shapiro, Brian P.
N1 - Publisher Copyright:
© 2015 by the Texas Heart ® Institute, Houston.
PY - 2015/10
Y1 - 2015/10
N2 - Percutaneous coronary intervention and coronary artery bypass grafting may be performed before orthotopic liver transplantation (OLT) to try to improve the condition of patients who have severe ischemic heart disease. However, data supporting improved outcomes are lacking. We reviewed the medical records of 2,010 patients who underwent OLT at our hospital from 2000 through 2010. The 51 patients who underwent coronary artery angiography within 6 months of transplantation were included in this study: 28 had mild coronary artery disease, 10 had moderate disease, and 13 had severe disease. We compared all-cause and cardiac-cause mortality rates. We found a significant difference in cardiac deaths between the groups (P <0.001), but none in all-cause death (P=0.624). Of the 10 patients who had moderate coronary artery disease, one underwent pre-transplant coronary artery bypass grafting. Of 13 patients with severe disease, 3 underwent percutaneous coronary intervention, and 6 underwent coronary artery bypass grafting. Overall, 50% of patients who underwent either intervention died of cardiac-related causes, whereas no patient died of a cardiac-related cause after undergoing neither intervention (P <0.0001). We conclude that, despite coronary intervention, mortality rates remain high in OLT patients who have severe coronary artery disease.
AB - Percutaneous coronary intervention and coronary artery bypass grafting may be performed before orthotopic liver transplantation (OLT) to try to improve the condition of patients who have severe ischemic heart disease. However, data supporting improved outcomes are lacking. We reviewed the medical records of 2,010 patients who underwent OLT at our hospital from 2000 through 2010. The 51 patients who underwent coronary artery angiography within 6 months of transplantation were included in this study: 28 had mild coronary artery disease, 10 had moderate disease, and 13 had severe disease. We compared all-cause and cardiac-cause mortality rates. We found a significant difference in cardiac deaths between the groups (P <0.001), but none in all-cause death (P=0.624). Of the 10 patients who had moderate coronary artery disease, one underwent pre-transplant coronary artery bypass grafting. Of 13 patients with severe disease, 3 underwent percutaneous coronary intervention, and 6 underwent coronary artery bypass grafting. Overall, 50% of patients who underwent either intervention died of cardiac-related causes, whereas no patient died of a cardiac-related cause after undergoing neither intervention (P <0.0001). We conclude that, despite coronary intervention, mortality rates remain high in OLT patients who have severe coronary artery disease.
KW - Coronary artery disease/complications/physiopathology
KW - Decision support techniques
KW - Liver transplantation
KW - Patient selection
KW - Predictive value of tests
KW - Retrospective studies
KW - Risk factors
KW - Treatment outcome
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U2 - 10.14503/THIJ-14-4738
DO - 10.14503/THIJ-14-4738
M3 - Article
C2 - 26504436
AN - SCOPUS:84943256064
SN - 0730-2347
VL - 42
SP - 438
EP - 442
JO - Texas Heart Institute Journal
JF - Texas Heart Institute Journal
IS - 5
ER -