Coronary hemodynamics in patients with symptomatic hypertrophic cardiomyopathy

Eric H. Yang; Tiong Cheng Yeo; Stuart T. Higano; Rick A. Nishimura; Amir Lerman

doi:10.1016/j.amjcard.2004.05.046

Coronary hemodynamics in patients with symptomatic hypertrophic cardiomyopathy

Eric H. Yang, Tiong Cheng Yeo, Stuart T. Higano, Rick A. Nishimura, Amir Lerman

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

The purpose of this study was to analyze coronary hemodynamics and determine a possible mechanism for microvascular dysfunction in patients with symptomatic hypertrophic cardiomyopathy (HC). Although patients with HC have been shown to have microvascular dysfunction and reduced coronary flow reserve (CFR), the mechanism by which this occurs is not well understood. We studied coronary hemodynamics in 8 patients with symptomatic HC and compared them with 8 matched controls. Compared with controls, patients with HC had higher coronary blood flow, lower coronary resistance, and lower CFR. Patients with HC also had abnormal phasic coronary flow characteristics. These results suggest that the reduction of CFR in patients with HC may be secondary to near maximal vasodilation of the microcirculation in the basal state.

Original language	English (US)
Pages (from-to)	685-687
Number of pages	3
Journal	American Journal of Cardiology
Volume	94
Issue number	5
DOIs	https://doi.org/10.1016/j.amjcard.2004.05.046
State	Published - Sep 1 2004

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.amjcard.2004.05.046

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abstract = "The purpose of this study was to analyze coronary hemodynamics and determine a possible mechanism for microvascular dysfunction in patients with symptomatic hypertrophic cardiomyopathy (HC). Although patients with HC have been shown to have microvascular dysfunction and reduced coronary flow reserve (CFR), the mechanism by which this occurs is not well understood. We studied coronary hemodynamics in 8 patients with symptomatic HC and compared them with 8 matched controls. Compared with controls, patients with HC had higher coronary blood flow, lower coronary resistance, and lower CFR. Patients with HC also had abnormal phasic coronary flow characteristics. These results suggest that the reduction of CFR in patients with HC may be secondary to near maximal vasodilation of the microcirculation in the basal state.",

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AU - Yang, Eric H.

AU - Yeo, Tiong Cheng

AU - Higano, Stuart T.

AU - Nishimura, Rick A.

AU - Lerman, Amir

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AB - The purpose of this study was to analyze coronary hemodynamics and determine a possible mechanism for microvascular dysfunction in patients with symptomatic hypertrophic cardiomyopathy (HC). Although patients with HC have been shown to have microvascular dysfunction and reduced coronary flow reserve (CFR), the mechanism by which this occurs is not well understood. We studied coronary hemodynamics in 8 patients with symptomatic HC and compared them with 8 matched controls. Compared with controls, patients with HC had higher coronary blood flow, lower coronary resistance, and lower CFR. Patients with HC also had abnormal phasic coronary flow characteristics. These results suggest that the reduction of CFR in patients with HC may be secondary to near maximal vasodilation of the microcirculation in the basal state.

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Coronary hemodynamics in patients with symptomatic hypertrophic cardiomyopathy

Abstract

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