Coronary flow reserve

Noninvasive measurement in humans with breath-hold velocity-encoded cine MR imaging

Hajime Sakuma, Louis M. Blake, Thomas M. Amidon, Margaret O'Sullivan, Dieter H. Szolar, Alain P. Furber, Matthew A Bernstein, Thomas K F Foo, Charles B. Higgins

Research output: Contribution to journalArticle

100 Citations (Scopus)

Abstract

PURPOSE: To measure coronary vasodilator reserve with breath-hold velocity-encoded cine magnetic resonance (MR) imaging. MATERIALS AND METHODS: Eight healthy adult volunteers underwent 1.5-T MR imaging. Velocity-encoded cine images were acquired at seven to 13 temporal phases in 25 seconds, with k-space segmentation and view-sharing reconstruction (±1 m/sec velocity- encoding value) (repetition time msec/echo time msec = 16/9). Flow velocity in the left anterior descending (LAD) artery was measured twice before and twice after administration of dipyridamole (0.56 mg per kilogram of body weight). RESULTS: Peak diastolic coronary flow velocity in the LAD artery was 14.8 cm/sec ± 1.9 (mean ± standard deviation) in the baseline state. It increased significantly (P < .01) to 46.3 cm/sec ± 10.2 after dipyridamole administration, with an average coronary reserve of 3.14 ± 0.59. Interstudy and interobserver reproducibilities for measurement of peak diastolic velocity were, respectively, 9.5% ± 1.6 and 7.0% ± .2.5 in the baseline state and 6.8% ± 2.2 and 3.4% ± 1.5 after dipyridamole administration. CONCLUSION: Breath-hold velocity-encoded cine MR imaging provided reproducible assessment of coronary flow reserve in humans.

Original languageEnglish (US)
Pages (from-to)745-750
Number of pages6
JournalRadiology
Volume198
Issue number3
StatePublished - Mar 1996
Externally publishedYes

Fingerprint

Cine Magnetic Resonance Imaging
Dipyridamole
Arteries
Vasodilator Agents
Healthy Volunteers
Body Weight
Magnetic Resonance Imaging

Keywords

  • Coronary vessels, flow dynamics
  • Coronary vessels, MR
  • Magnetic resonance (MR), cine study
  • Magnetic resonance (MR), phase imaging
  • Magnetic resonance (MR), rapid imaging
  • Magnetic resonance (MR), vascular studies

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Sakuma, H., Blake, L. M., Amidon, T. M., O'Sullivan, M., Szolar, D. H., Furber, A. P., ... Higgins, C. B. (1996). Coronary flow reserve: Noninvasive measurement in humans with breath-hold velocity-encoded cine MR imaging. Radiology, 198(3), 745-750.

Coronary flow reserve : Noninvasive measurement in humans with breath-hold velocity-encoded cine MR imaging. / Sakuma, Hajime; Blake, Louis M.; Amidon, Thomas M.; O'Sullivan, Margaret; Szolar, Dieter H.; Furber, Alain P.; Bernstein, Matthew A; Foo, Thomas K F; Higgins, Charles B.

In: Radiology, Vol. 198, No. 3, 03.1996, p. 745-750.

Research output: Contribution to journalArticle

Sakuma, H, Blake, LM, Amidon, TM, O'Sullivan, M, Szolar, DH, Furber, AP, Bernstein, MA, Foo, TKF & Higgins, CB 1996, 'Coronary flow reserve: Noninvasive measurement in humans with breath-hold velocity-encoded cine MR imaging', Radiology, vol. 198, no. 3, pp. 745-750.
Sakuma H, Blake LM, Amidon TM, O'Sullivan M, Szolar DH, Furber AP et al. Coronary flow reserve: Noninvasive measurement in humans with breath-hold velocity-encoded cine MR imaging. Radiology. 1996 Mar;198(3):745-750.
Sakuma, Hajime ; Blake, Louis M. ; Amidon, Thomas M. ; O'Sullivan, Margaret ; Szolar, Dieter H. ; Furber, Alain P. ; Bernstein, Matthew A ; Foo, Thomas K F ; Higgins, Charles B. / Coronary flow reserve : Noninvasive measurement in humans with breath-hold velocity-encoded cine MR imaging. In: Radiology. 1996 ; Vol. 198, No. 3. pp. 745-750.
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abstract = "PURPOSE: To measure coronary vasodilator reserve with breath-hold velocity-encoded cine magnetic resonance (MR) imaging. MATERIALS AND METHODS: Eight healthy adult volunteers underwent 1.5-T MR imaging. Velocity-encoded cine images were acquired at seven to 13 temporal phases in 25 seconds, with k-space segmentation and view-sharing reconstruction (±1 m/sec velocity- encoding value) (repetition time msec/echo time msec = 16/9). Flow velocity in the left anterior descending (LAD) artery was measured twice before and twice after administration of dipyridamole (0.56 mg per kilogram of body weight). RESULTS: Peak diastolic coronary flow velocity in the LAD artery was 14.8 cm/sec ± 1.9 (mean ± standard deviation) in the baseline state. It increased significantly (P < .01) to 46.3 cm/sec ± 10.2 after dipyridamole administration, with an average coronary reserve of 3.14 ± 0.59. Interstudy and interobserver reproducibilities for measurement of peak diastolic velocity were, respectively, 9.5{\%} ± 1.6 and 7.0{\%} ± .2.5 in the baseline state and 6.8{\%} ± 2.2 and 3.4{\%} ± 1.5 after dipyridamole administration. CONCLUSION: Breath-hold velocity-encoded cine MR imaging provided reproducible assessment of coronary flow reserve in humans.",
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AU - O'Sullivan, Margaret

AU - Szolar, Dieter H.

AU - Furber, Alain P.

AU - Bernstein, Matthew A

AU - Foo, Thomas K F

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N2 - PURPOSE: To measure coronary vasodilator reserve with breath-hold velocity-encoded cine magnetic resonance (MR) imaging. MATERIALS AND METHODS: Eight healthy adult volunteers underwent 1.5-T MR imaging. Velocity-encoded cine images were acquired at seven to 13 temporal phases in 25 seconds, with k-space segmentation and view-sharing reconstruction (±1 m/sec velocity- encoding value) (repetition time msec/echo time msec = 16/9). Flow velocity in the left anterior descending (LAD) artery was measured twice before and twice after administration of dipyridamole (0.56 mg per kilogram of body weight). RESULTS: Peak diastolic coronary flow velocity in the LAD artery was 14.8 cm/sec ± 1.9 (mean ± standard deviation) in the baseline state. It increased significantly (P < .01) to 46.3 cm/sec ± 10.2 after dipyridamole administration, with an average coronary reserve of 3.14 ± 0.59. Interstudy and interobserver reproducibilities for measurement of peak diastolic velocity were, respectively, 9.5% ± 1.6 and 7.0% ± .2.5 in the baseline state and 6.8% ± 2.2 and 3.4% ± 1.5 after dipyridamole administration. CONCLUSION: Breath-hold velocity-encoded cine MR imaging provided reproducible assessment of coronary flow reserve in humans.

AB - PURPOSE: To measure coronary vasodilator reserve with breath-hold velocity-encoded cine magnetic resonance (MR) imaging. MATERIALS AND METHODS: Eight healthy adult volunteers underwent 1.5-T MR imaging. Velocity-encoded cine images were acquired at seven to 13 temporal phases in 25 seconds, with k-space segmentation and view-sharing reconstruction (±1 m/sec velocity- encoding value) (repetition time msec/echo time msec = 16/9). Flow velocity in the left anterior descending (LAD) artery was measured twice before and twice after administration of dipyridamole (0.56 mg per kilogram of body weight). RESULTS: Peak diastolic coronary flow velocity in the LAD artery was 14.8 cm/sec ± 1.9 (mean ± standard deviation) in the baseline state. It increased significantly (P < .01) to 46.3 cm/sec ± 10.2 after dipyridamole administration, with an average coronary reserve of 3.14 ± 0.59. Interstudy and interobserver reproducibilities for measurement of peak diastolic velocity were, respectively, 9.5% ± 1.6 and 7.0% ± .2.5 in the baseline state and 6.8% ± 2.2 and 3.4% ± 1.5 after dipyridamole administration. CONCLUSION: Breath-hold velocity-encoded cine MR imaging provided reproducible assessment of coronary flow reserve in humans.

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