Abstract
Aim Angina pectoris in the absence of obstructive coronary artery disease (CAD) is common and is associated with poor quality of life (QOL). Coronary microvascular endothelial dysfunction is associated with myocardial ischaemia and is a common cause of angina. We hypothesise that evaluation of coronary endothelial function, its diagnosis and treatment will favourably impact QOL in patients with angina symptoms and non-obstructive CAD. Methods and results Follow-up was done on 457 patients with chest pain and non-obstructive coronary arteries who had undergone coronary vascular reactivity evaluation by administration of intracoronary acetylcholine at the time of diagnostic study. After a mean follow-up of 8.4±4.7 years, QOL was assessed by administration of the SF-36 QOL survey. Patients diagnosed and treated for microvascular endothelial dysfunction had a higher (better) overall mental composite score (44.8 vs 40.9, p=0.036) and mental health score (44.2 vs 40.7, p=0.047), and a trend towards higher vitality scores (39.1 vs 35.9, p=0.053) and role emotional scores (43.6 vs 40.4, p=0.073), compared with patients with normal endothelial function. Conclusion Among patients with chest pain and normal coronaries, diagnosis and treatment of coronary microvascular endothelial dysfunction in those with angina pectoris and non-obstructive CAD are associated with better QOL compared with patients with normal endothelial function.
| Original language | English (US) |
|---|---|
| Article number | e000870 |
| Journal | Open Heart |
| Volume | 6 |
| Issue number | 1 |
| DOIs | |
| State | Published - Feb 1 2019 |
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Keywords
- angina
- microvascular endothelial function
- quality of life
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Coronary endothelial function testing may improve long-term quality of life in subjects with microvascular coronary endothelial dysfunction. / Reriani, Martin; Flammer, Andreas J.; Duhé, Jessica; Li, Jing; Gulati, Rajiv; Rihal, Charanjit; Lennon, Ryan; Tilford, Jonella M.; Prasad, Abhiram; Lerman, Lilach O; Lerman, Amir.
In: Open Heart, Vol. 6, No. 1, e000870, 01.02.2019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Coronary endothelial function testing may improve long-term quality of life in subjects with microvascular coronary endothelial dysfunction
AU - Reriani, Martin
AU - Flammer, Andreas J.
AU - Duhé, Jessica
AU - Li, Jing
AU - Gulati, Rajiv
AU - Rihal, Charanjit
AU - Lennon, Ryan
AU - Tilford, Jonella M.
AU - Prasad, Abhiram
AU - Lerman, Lilach O
AU - Lerman, Amir
PY - 2019/2/1
Y1 - 2019/2/1
N2 - Aim Angina pectoris in the absence of obstructive coronary artery disease (CAD) is common and is associated with poor quality of life (QOL). Coronary microvascular endothelial dysfunction is associated with myocardial ischaemia and is a common cause of angina. We hypothesise that evaluation of coronary endothelial function, its diagnosis and treatment will favourably impact QOL in patients with angina symptoms and non-obstructive CAD. Methods and results Follow-up was done on 457 patients with chest pain and non-obstructive coronary arteries who had undergone coronary vascular reactivity evaluation by administration of intracoronary acetylcholine at the time of diagnostic study. After a mean follow-up of 8.4±4.7 years, QOL was assessed by administration of the SF-36 QOL survey. Patients diagnosed and treated for microvascular endothelial dysfunction had a higher (better) overall mental composite score (44.8 vs 40.9, p=0.036) and mental health score (44.2 vs 40.7, p=0.047), and a trend towards higher vitality scores (39.1 vs 35.9, p=0.053) and role emotional scores (43.6 vs 40.4, p=0.073), compared with patients with normal endothelial function. Conclusion Among patients with chest pain and normal coronaries, diagnosis and treatment of coronary microvascular endothelial dysfunction in those with angina pectoris and non-obstructive CAD are associated with better QOL compared with patients with normal endothelial function.
AB - Aim Angina pectoris in the absence of obstructive coronary artery disease (CAD) is common and is associated with poor quality of life (QOL). Coronary microvascular endothelial dysfunction is associated with myocardial ischaemia and is a common cause of angina. We hypothesise that evaluation of coronary endothelial function, its diagnosis and treatment will favourably impact QOL in patients with angina symptoms and non-obstructive CAD. Methods and results Follow-up was done on 457 patients with chest pain and non-obstructive coronary arteries who had undergone coronary vascular reactivity evaluation by administration of intracoronary acetylcholine at the time of diagnostic study. After a mean follow-up of 8.4±4.7 years, QOL was assessed by administration of the SF-36 QOL survey. Patients diagnosed and treated for microvascular endothelial dysfunction had a higher (better) overall mental composite score (44.8 vs 40.9, p=0.036) and mental health score (44.2 vs 40.7, p=0.047), and a trend towards higher vitality scores (39.1 vs 35.9, p=0.053) and role emotional scores (43.6 vs 40.4, p=0.073), compared with patients with normal endothelial function. Conclusion Among patients with chest pain and normal coronaries, diagnosis and treatment of coronary microvascular endothelial dysfunction in those with angina pectoris and non-obstructive CAD are associated with better QOL compared with patients with normal endothelial function.
KW - angina
KW - microvascular endothelial function
KW - quality of life
UR - http://www.scopus.com/inward/record.url?scp=85061089975&partnerID=8YFLogxK
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U2 - 10.1136/openhrt-2018-000870
DO - 10.1136/openhrt-2018-000870
M3 - Article
VL - 6
JO - Open Heart
JF - Open Heart
SN - 2053-3624
IS - 1
M1 - e000870
ER -