Coronary endothelial dysfunction is associated with inflammation and vasa vasorum proliferation in patients with early atherosclerosis

Byoung Joo Choi, Yoshiki Matsuo, Tatsuo Aoki, Taek Geun Kwon, Abhiram Prasad, Rajiv Gulati, Ryan J. Lennon, Lilach O Lerman, Amir Lerman

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Conclusions-Epicardial endothelial dysfunction was associated with optical coherence tomography -identified macrophages and microchannels in mild coronary atherosclerosis. The current study further supports the role of inflammation and vasa vasorum proliferation in the early stage of coronary atherosclerosis.

Objective-Endothelial dysfunction is an early manifestation of atherosclerosis. Inflammation and vasa vasorum play a pivotal role in the pathophysiology of plaque initiation, development, and complications. Optical coherence tomography allows high-resolution imaging of tissue microstructure. Therefore, the aim of this study was to test the hypothesis that segments with endothelial dysfunction show macrophages and vasa vasorum in patients with early coronary artery disease.

Approach and Results-Optical coherence tomography images were obtained from 40 patients with mild coronary atherosclerosis who underwent coronary endothelial function assessment. Optical coherence tomography findings, including macrophages and microchannels, were evaluated in 76 coronary segments corresponding to those in endothelial response to acetylcholine. Coronary artery diameter change in response to acetylcholine was more severe in segments showing macrophages (-17.7±14.7% versus -6.3±13.9%; P<0.01) and microchannels (-15.9±15.9% versus -6.4±13.5%; P<0.01) than those without. There were increasing trends of the prevalence of macrophages and microchannels with endothelial dysfunction as stratified by quartiles of coronary artery diameter change (P<0.01 and P=0.02 for trend, respectively). In particular, segments with both macrophages and microchannels (n=12) tended to have worse endothelial function than those with macrophages alone (n=15) and microchannels alone (n=15; -22.1±14.6% versus -10.9±15.6% and -10.9±15.6%; P=0.07 and P=0.06, respectively).

Original languageEnglish (US)
Pages (from-to)2473-2477
Number of pages5
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume34
Issue number11
DOIs
StatePublished - Nov 1 2014

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Vasa Vasorum
Atherosclerosis
Macrophages
Inflammation
Optical Coherence Tomography
Coronary Artery Disease
Acetylcholine
Coronary Vessels

Keywords

  • Coronary disease
  • Inflammation
  • Optical coherence tomography

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Coronary endothelial dysfunction is associated with inflammation and vasa vasorum proliferation in patients with early atherosclerosis. / Choi, Byoung Joo; Matsuo, Yoshiki; Aoki, Tatsuo; Kwon, Taek Geun; Prasad, Abhiram; Gulati, Rajiv; Lennon, Ryan J.; Lerman, Lilach O; Lerman, Amir.

In: Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 34, No. 11, 01.11.2014, p. 2473-2477.

Research output: Contribution to journalArticle

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abstract = "Conclusions-Epicardial endothelial dysfunction was associated with optical coherence tomography -identified macrophages and microchannels in mild coronary atherosclerosis. The current study further supports the role of inflammation and vasa vasorum proliferation in the early stage of coronary atherosclerosis.Objective-Endothelial dysfunction is an early manifestation of atherosclerosis. Inflammation and vasa vasorum play a pivotal role in the pathophysiology of plaque initiation, development, and complications. Optical coherence tomography allows high-resolution imaging of tissue microstructure. Therefore, the aim of this study was to test the hypothesis that segments with endothelial dysfunction show macrophages and vasa vasorum in patients with early coronary artery disease.Approach and Results-Optical coherence tomography images were obtained from 40 patients with mild coronary atherosclerosis who underwent coronary endothelial function assessment. Optical coherence tomography findings, including macrophages and microchannels, were evaluated in 76 coronary segments corresponding to those in endothelial response to acetylcholine. Coronary artery diameter change in response to acetylcholine was more severe in segments showing macrophages (-17.7±14.7{\%} versus -6.3±13.9{\%}; P<0.01) and microchannels (-15.9±15.9{\%} versus -6.4±13.5{\%}; P<0.01) than those without. There were increasing trends of the prevalence of macrophages and microchannels with endothelial dysfunction as stratified by quartiles of coronary artery diameter change (P<0.01 and P=0.02 for trend, respectively). In particular, segments with both macrophages and microchannels (n=12) tended to have worse endothelial function than those with macrophages alone (n=15) and microchannels alone (n=15; -22.1±14.6{\%} versus -10.9±15.6{\%} and -10.9±15.6{\%}; P=0.07 and P=0.06, respectively).",
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AU - Matsuo, Yoshiki

AU - Aoki, Tatsuo

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AU - Prasad, Abhiram

AU - Gulati, Rajiv

AU - Lennon, Ryan J.

AU - Lerman, Lilach O

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