Coronary Endothelial Dysfunction in Women with Type 2 Diabetes Measured by Coronary Phase Contrast Flow Velocity Magnetic Resonance Imaging

Christopher D. Maroules, Alice Y Chang, Melanie S. Kotys-Traughber, Ronald M. Peshock

Research output: Contribution to journalArticle

Abstract

Objective The aim of this study was to determine if differences in coronary endothelial function are observed between asymptomatic women with type 2 diabetes mellitus (DM) and control subjects using coronary phase contrast flow velocity magnetic resonance imaging in response to cold pressor stress, an established endothelium-dependent vasodilatory stress. Methods Phase contrast flow velocity imaging of the right coronary artery was performed in 7 asymptomatic premenopausal women with DM and 8 healthy female participants in response to the cold pressor test at 3 T. Results There was no significant difference in percent increase in coronary flow velocity from rest to peak flow velocity between DM and control subjects (32% ± 22% vs 46% ± 17%; P = 0.11). However, percent increase in coronary flow velocity was lower in DM than in control subjects (-3% ± 14% vs 31% ± 30%; P = 0.01) during the second minute of cold pressor stress, when endothelial-mediated vasodilation should occur. Conclusions Asymptomatic women with DM demonstrate reduced coronary flow velocity during the second minute of cold pressor stress, indicating coronary endothelial dysfunction.

Original languageEnglish (US)
Pages (from-to)856-861
Number of pages6
JournalJournal of Investigative Medicine
Volume63
Issue number7
DOIs
StatePublished - Oct 1 2015

Fingerprint

Medical problems
Flow velocity
Type 2 Diabetes Mellitus
Diabetes Mellitus
Magnetic Resonance Imaging
Vasodilation
Endothelium
Imaging techniques
Coronary Vessels
Healthy Volunteers
Magnetic resonance

Keywords

  • cardiac magnetic resonance
  • coronary blood flow reserve
  • coronary flow
  • endothelial dysfunction

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Coronary Endothelial Dysfunction in Women with Type 2 Diabetes Measured by Coronary Phase Contrast Flow Velocity Magnetic Resonance Imaging. / Maroules, Christopher D.; Chang, Alice Y; Kotys-Traughber, Melanie S.; Peshock, Ronald M.

In: Journal of Investigative Medicine, Vol. 63, No. 7, 01.10.2015, p. 856-861.

Research output: Contribution to journalArticle

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AB - Objective The aim of this study was to determine if differences in coronary endothelial function are observed between asymptomatic women with type 2 diabetes mellitus (DM) and control subjects using coronary phase contrast flow velocity magnetic resonance imaging in response to cold pressor stress, an established endothelium-dependent vasodilatory stress. Methods Phase contrast flow velocity imaging of the right coronary artery was performed in 7 asymptomatic premenopausal women with DM and 8 healthy female participants in response to the cold pressor test at 3 T. Results There was no significant difference in percent increase in coronary flow velocity from rest to peak flow velocity between DM and control subjects (32% ± 22% vs 46% ± 17%; P = 0.11). However, percent increase in coronary flow velocity was lower in DM than in control subjects (-3% ± 14% vs 31% ± 30%; P = 0.01) during the second minute of cold pressor stress, when endothelial-mediated vasodilation should occur. Conclusions Asymptomatic women with DM demonstrate reduced coronary flow velocity during the second minute of cold pressor stress, indicating coronary endothelial dysfunction.

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