Coronary artery endothelial function after myocardial ischemia and reperfusion

John F. Seccombe, Hartzell V Schaff

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Background.: The consequences of ischemia-reperfusion injury on myocytes has been studied intensely, and previous investigations of methods of myocardial protection during global and regional ischemia have focused on resultant alterations in myocardial function. However, the coronary artery endothelium is also vulnerable to damage, and only recently have investigators been able to assess coronary endothelial function. Methods.: This review examines some aspects of coronary flow abnormalities that occur after ischemia and reperfusion. In addition, we summarize recent data that address the hypothesis that injury to the coronary artery endothelium may contribute to the pathophysiology of global (and regional) cardiac ischemia and reperfusion. Results.: It appears that ischemia and reperfusion selectively injure a component in the receptor/G-protein complex linking receptor-stimulus coupling to the activation of nitric oxide synthase. Further, oxygen radicals may contribute to this injury. Recent investigations demonstrate that oxygen radicals impair the receptor/G-protein complex specific to the nitric oxide signal transduction pathway rather than causing global receptor/G-protein dysfunction. Conclusions.: The understanding of endothelial cell function and the elucidation of the nitric oxide pathway should further clarify our understanding of the pathogenesis of endothelial reperfusion injury and coronary vasospasm and contribute to the development of effective therapeutic interventions.

Original languageEnglish (US)
Pages (from-to)778-788
Number of pages11
JournalThe Annals of Thoracic Surgery
Volume60
Issue number3
DOIs
StatePublished - 1995

Fingerprint

Myocardial Reperfusion
Myocardial Ischemia
Coronary Vessels
Ischemia
GTP-Binding Proteins
Reperfusion
Reperfusion Injury
Endothelium
Reactive Oxygen Species
Nitric Oxide
Coronary Vasospasm
Wounds and Injuries
Nitric Oxide Synthase
Muscle Cells
Signal Transduction
Endothelial Cells
Research Personnel
Therapeutics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pulmonary and Respiratory Medicine
  • Surgery

Cite this

Coronary artery endothelial function after myocardial ischemia and reperfusion. / Seccombe, John F.; Schaff, Hartzell V.

In: The Annals of Thoracic Surgery, Vol. 60, No. 3, 1995, p. 778-788.

Research output: Contribution to journalArticle

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