TY - JOUR
T1 - Corneal Aberrations and Visual Acuity After Laser In Situ Keratomileusis
T2 - Femtosecond Laser Versus Mechanical Microkeratome
AU - Calvo, Ramón
AU - McLaren, Jay W.
AU - Hodge, David O.
AU - Bourne, William M.
AU - Patel, Sanjay V.
N1 - Funding Information:
Funding/support was provided by National Institutes of Health, Bethesda, Maryland (Grant EY 02037 ; W.M.B.); Research to Prevent Blindness, Inc, New York, New York (S.V.P. as Olga Keith Wiess Special Scholar, and an unrestricted departmental grant); and Mayo Foundation, Rochester, Minnesota. The authors indicate no financial conflict of interest. Involved in design of the study (J.W.M., W.M.B., S.V.P.); conduct of the study (J.W.M., W.M.B., S.V.P.); collection (R.C., J.W.M., S.V.P.), management (R.C., J.W.M., S.V.P.), analysis (R.C., J.W.M., D.O.H., S.V.P.), and interpretation (R.C., J.W.M., D.O.H., W.M.B., S.V.P.) of the data; and preparation (R.C., S.V.P.), review (R.C., J.W.M., D.O.H., W.M.B., S.V.P.), and approval (R.C., J.W.M., D.O.H., W.M.B., S.V.P.) of the manuscript. This study was approved by the Mayo Clinic Institutional Review Board and complied with HIPAA regulations; informed consent was obtained from all subjects after discussion of the risks and consequences of the study. The trial was registered at www.clinicaltrials.gov with identifier # NCT00350246 .
PY - 2010/5
Y1 - 2010/5
N2 - Purpose: To compare corneal high-order aberrations and visual acuity after laser in situ keratomileusis (LASIK) with the flap created by a femtosecond laser (bladeless) to LASIK with the flap created by a mechanical microkeratome. Design: Prospective, randomized, paired-eye study. Methods: Fellow eyes of 21 patients with myopia or myopic astigmatism were randomized by ocular dominance. Corneal topography and visual acuity were measured before and at 1, 3, 6, 12, and 36 months after LASIK. Wavefront errors from the anterior corneal surface were calculated from the topography data over 4- and 6-mm-diameter pupils and decomposed into Zernike polynomials to the 6th order. Results: There were no differences in corneal total high-order aberrations, spherical aberration, coma, or trefoil between methods of flap creation at any examination over 4- and 6-mm-diameter pupils. Over a 6-mm pupil, total high-order aberrations increased by 1 month after LASIK with both treatments (P ≤ .001) and remained increased through 36 months (P ≤ .001). Uncorrected and best-corrected visual acuity did not differ between methods at any examination and remained stable postoperatively through 3 years; the minimum detectable difference in visual acuity between treatments was ≤0.1 logMAR (≤1 line of vision, α = 0.05/6, β = 0.20, n = 21). Conclusions: The planar configuration of the femtosecond laser flap did not offer any advantage in corneal high-order aberrations or visual acuity through 3 years after LASIK. Corneal high-order aberrations remain stable through 3 years after LASIK.
AB - Purpose: To compare corneal high-order aberrations and visual acuity after laser in situ keratomileusis (LASIK) with the flap created by a femtosecond laser (bladeless) to LASIK with the flap created by a mechanical microkeratome. Design: Prospective, randomized, paired-eye study. Methods: Fellow eyes of 21 patients with myopia or myopic astigmatism were randomized by ocular dominance. Corneal topography and visual acuity were measured before and at 1, 3, 6, 12, and 36 months after LASIK. Wavefront errors from the anterior corneal surface were calculated from the topography data over 4- and 6-mm-diameter pupils and decomposed into Zernike polynomials to the 6th order. Results: There were no differences in corneal total high-order aberrations, spherical aberration, coma, or trefoil between methods of flap creation at any examination over 4- and 6-mm-diameter pupils. Over a 6-mm pupil, total high-order aberrations increased by 1 month after LASIK with both treatments (P ≤ .001) and remained increased through 36 months (P ≤ .001). Uncorrected and best-corrected visual acuity did not differ between methods at any examination and remained stable postoperatively through 3 years; the minimum detectable difference in visual acuity between treatments was ≤0.1 logMAR (≤1 line of vision, α = 0.05/6, β = 0.20, n = 21). Conclusions: The planar configuration of the femtosecond laser flap did not offer any advantage in corneal high-order aberrations or visual acuity through 3 years after LASIK. Corneal high-order aberrations remain stable through 3 years after LASIK.
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U2 - 10.1016/j.ajo.2009.12.023
DO - 10.1016/j.ajo.2009.12.023
M3 - Article
C2 - 20227675
AN - SCOPUS:77950866155
SN - 0002-9394
VL - 149
SP - 785
EP - 793
JO - American journal of ophthalmology
JF - American journal of ophthalmology
IS - 5
ER -