Cordyceps sinensis extracts do not prevent Fas-receptor and hydrogen peroxide-induced T-cell apoptosis

E. J. Buenz, J. G. Weaver, B. A. Bauer, S. D. Chalpin, A. D. Badley

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Aqueous and alcohol extracts of Cordyceps sinensis (Berk) Succ. are used as a traditional medicine in China for the treatment of a wide range of diseases and are reported to have antioxidant and antiapoptotic properties. We therefore examined the ability of aqueous, organic, and alcohol extracts of Cordyceps sinensis to inhibit apoptosis induced either by hydrogen peroxide or Fas-receptor ligation; both stimuli induce apoptosis dependent on reactive oxygen species. Cells pre-incubated with Cordyceps sinensis extracts were equally sensitive to hydrogen peroxide and Fas-mediated apoptosis. Thus, the putative antioxidant and antiapoptotic properties of Cordyceps sinensis are insufficient to rescue cells from apoptosis induced by these stimuli in vitro.

Original languageEnglish (US)
Pages (from-to)57-62
Number of pages6
JournalJournal of Ethnopharmacology
Volume90
Issue number1
DOIs
StatePublished - Jan 2004

Keywords

  • Apoptosis
  • Cordyceps sinensis
  • Reactive oxygen species
  • Traditional medicine

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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