Corded and hyalinized mesonephric-like adenocarcinoma of the uterine corpus

report of a case mimicking endometrioid carcinoma

Vatsal Patel, Benjamin Kipp, J. Kenneth Schoolmeester

Research output: Contribution to journalArticle

Abstract

Mesonephric-like adenocarcinoma is a recently described adenocarcinoma of the uterine body and ovary with overlapping features of mesonephric adenocarcinoma and endometrioid carcinoma. It is thought to be a mullerian adenocarcinoma that has differentiated along mesonephric lines. A 71-year-old woman had a 3-cm endometrial mass that invaded the myometrium without gross or microscopic evidence of cervical involvement. The tumor had a variety of architectural patterns and produced prominent stromal hyalinization containing embedded cords and trabeculae of tumor cells. No squamous or mucinous differentiation or associated mesonephric remnants or hyperplasia was identified. The tumor was positive for TTF1 and GATA3, very focally and weakly positive for estrogen receptor and negative for progesterone receptor and nuclear expression of β-catenin. An unusual inverse pattern of TTF1 and GATA3 immunoreactivity was observed. DNA analysis by digital droplet polymerase chain reaction and quantitative polymerase chain reaction identified an activating KRAS (G12A) mutation. The tumor was interpreted as corded and hyalinized mesonephric-like adenocarcinoma that mimicked corded and hyalinized endometrioid carcinoma.

Original languageEnglish (US)
Pages (from-to)243-248
Number of pages6
JournalHuman Pathology
Volume86
DOIs
StatePublished - Apr 1 2019

Fingerprint

Endometrioid Carcinoma
Adenocarcinoma
Neoplasms
Catenins
Polymerase Chain Reaction
Myometrium
Progesterone Receptors
Estrogen Receptors
Hyperplasia
Ovary
Mutation
DNA

Keywords

  • Corded and hyalinized
  • Endometrioid carcinoma
  • Endometrium
  • Mesonephric-like adenocarcinoma
  • Uterus

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Corded and hyalinized mesonephric-like adenocarcinoma of the uterine corpus : report of a case mimicking endometrioid carcinoma. / Patel, Vatsal; Kipp, Benjamin; Schoolmeester, J. Kenneth.

In: Human Pathology, Vol. 86, 01.04.2019, p. 243-248.

Research output: Contribution to journalArticle

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