Coprophagia in neurologic disorders

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

We report on the unusual behavior of coprophagia (eating one’s own feces) in neurologic disorders. The Mayo Clinic Health Sciences-computerized clinical database was queried for all patients evaluated at our institution between 1995 and 2015 in which coprophagia was documented in the medical records. Twenty-six patients were identified of which 17 had coprophagia. Of the 17 patients, five were excluded due to age at onset less than 10 years, leaving 12 adult patients for this study. The median age at onset of coprophagia in the 12 patients was 55 years (range 20–88 years), and half were female. Additional behaviors were common including scatolia (fecal smearing), hypersexuality, aggression, and pica (eating objects of any kind). Coprophagia was associated with neurodegenerative dementia in six patients, developmental delay in two, and one each with seizures, steroid psychosis, frontal lobe tumor, and schizoaffective disorder. Brain imaging in the six patients with dementia showed moderate-to-severe medial temporal lobe atrophy, as well as mild frontal lobe atrophy. Autopsy examination was performed in one patient and revealed frontotemporal lobar degeneration pathology. Many different behavioral and pharmacologic therapies were implemented, yet only haloperidol was associated with discontinuation of the behavior. Coprophagia is associated with different neurologic disorders, particularly neurodegenerative dementias. The behavior may be related to medial temporal lobe atrophy, similar to the Klüver–Bucy syndrome. Haloperidol appears to be effective in treating the behavior, at least in some patients.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalJournal of Neurology
DOIs
StateAccepted/In press - Mar 26 2016

Fingerprint

Coprophagia
Nervous System Diseases
Atrophy
Dementia
Frontal Lobe
Haloperidol
Temporal Lobe
Age of Onset
Psychotic Disorders
Pica
Frontotemporal Lobar Degeneration
Feeding Behavior
Aggression
Neuroimaging
Feces
Medical Records
Autopsy
Seizures
Eating

Keywords

  • Alzheimer’s disease
  • Coprophagia
  • Dementia
  • Frontotemporal dementia
  • Haloperidol
  • Seizures
  • Semantic dementia
  • TDP-43
  • Temporal lobe

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Coprophagia in neurologic disorders. / Josephs, Keith Anthony; Whitwell, Jennifer Lynn; Parisi, Joseph E; Lapid, Maria Isabel.

In: Journal of Neurology, 26.03.2016, p. 1-7.

Research output: Contribution to journalArticle

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