Copper deposition in focal nodular hyperplasia and inflammatory hepatocellular adenoma

Vishal S. Chandan, Sejal M Shah, Taofic Mounajjed, Michael Torbenson, Tsung-Teh Wu

Research output: Contribution to journalArticle

Abstract

AIMS: To examine copper deposition in focal nodular hyperplasia (FNH) and inflammatory hepatocellular adenoma (IHA) and to determine if it can play a role in their differentiation.

METHODS: 28 FNHs and 19 IHAs from surgical resections showing typical morphological and immunohistochemical features were stained with rhodanine to evaluate for copper deposition. Histological features such as nodularity, fibrous bands, ductular proliferation, steatosis, ballooned hepatocytes and lymphocytic inflammation were also scored.

RESULTS: Copper deposition was detected in 96% (27/28) of FNHs and 37% (7/19) of IHAs, P<0.001. In all cases, copper was seen within the hepatocytes only around the pseudo-portal tracts or areas of fibrosis. Copper deposition in IHA was significantly associated with presence of lymphocytic inflammation (P=0.04) but not associated with features like nodularity, fibrous bands, ductular proliferation, ballooned hepatocytes and steatosis (P>0.05, for all). In FNH, the presence and degree of copper deposition was not significantly associated with any histological features (P>0.05, for all).

CONCLUSIONS: Copper deposition occurs more frequently in FNH (96%) than IHA (37%), P<0.001. However, the presence of copper alone cannot be used as a feature to differentiate between FNH and IHA.

Original languageEnglish (US)
Pages (from-to)504-507
Number of pages4
JournalJournal of Clinical Pathology
Volume71
Issue number6
DOIs
StatePublished - Jun 1 2018

Fingerprint

Liver Cell Adenoma
Focal Nodular Hyperplasia
Copper
Rhodanine
Hepatocytes
Inflammation

Keywords

  • histopathology
  • liver
  • staining

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Copper deposition in focal nodular hyperplasia and inflammatory hepatocellular adenoma. / Chandan, Vishal S.; Shah, Sejal M; Mounajjed, Taofic; Torbenson, Michael; Wu, Tsung-Teh.

In: Journal of Clinical Pathology, Vol. 71, No. 6, 01.06.2018, p. 504-507.

Research output: Contribution to journalArticle

@article{f00f44dc27264708952cf37a19e4c9fd,
title = "Copper deposition in focal nodular hyperplasia and inflammatory hepatocellular adenoma",
abstract = "AIMS: To examine copper deposition in focal nodular hyperplasia (FNH) and inflammatory hepatocellular adenoma (IHA) and to determine if it can play a role in their differentiation.METHODS: 28 FNHs and 19 IHAs from surgical resections showing typical morphological and immunohistochemical features were stained with rhodanine to evaluate for copper deposition. Histological features such as nodularity, fibrous bands, ductular proliferation, steatosis, ballooned hepatocytes and lymphocytic inflammation were also scored.RESULTS: Copper deposition was detected in 96{\%} (27/28) of FNHs and 37{\%} (7/19) of IHAs, P<0.001. In all cases, copper was seen within the hepatocytes only around the pseudo-portal tracts or areas of fibrosis. Copper deposition in IHA was significantly associated with presence of lymphocytic inflammation (P=0.04) but not associated with features like nodularity, fibrous bands, ductular proliferation, ballooned hepatocytes and steatosis (P>0.05, for all). In FNH, the presence and degree of copper deposition was not significantly associated with any histological features (P>0.05, for all).CONCLUSIONS: Copper deposition occurs more frequently in FNH (96{\%}) than IHA (37{\%}), P<0.001. However, the presence of copper alone cannot be used as a feature to differentiate between FNH and IHA.",
keywords = "histopathology, liver, staining",
author = "Chandan, {Vishal S.} and Shah, {Sejal M} and Taofic Mounajjed and Michael Torbenson and Tsung-Teh Wu",
year = "2018",
month = "6",
day = "1",
doi = "10.1136/jclinpath-2017-204820",
language = "English (US)",
volume = "71",
pages = "504--507",
journal = "Molecular pathology : MP",
issn = "0021-9746",
publisher = "BMJ Publishing Group",
number = "6",

}

TY - JOUR

T1 - Copper deposition in focal nodular hyperplasia and inflammatory hepatocellular adenoma

AU - Chandan, Vishal S.

AU - Shah, Sejal M

AU - Mounajjed, Taofic

AU - Torbenson, Michael

AU - Wu, Tsung-Teh

PY - 2018/6/1

Y1 - 2018/6/1

N2 - AIMS: To examine copper deposition in focal nodular hyperplasia (FNH) and inflammatory hepatocellular adenoma (IHA) and to determine if it can play a role in their differentiation.METHODS: 28 FNHs and 19 IHAs from surgical resections showing typical morphological and immunohistochemical features were stained with rhodanine to evaluate for copper deposition. Histological features such as nodularity, fibrous bands, ductular proliferation, steatosis, ballooned hepatocytes and lymphocytic inflammation were also scored.RESULTS: Copper deposition was detected in 96% (27/28) of FNHs and 37% (7/19) of IHAs, P<0.001. In all cases, copper was seen within the hepatocytes only around the pseudo-portal tracts or areas of fibrosis. Copper deposition in IHA was significantly associated with presence of lymphocytic inflammation (P=0.04) but not associated with features like nodularity, fibrous bands, ductular proliferation, ballooned hepatocytes and steatosis (P>0.05, for all). In FNH, the presence and degree of copper deposition was not significantly associated with any histological features (P>0.05, for all).CONCLUSIONS: Copper deposition occurs more frequently in FNH (96%) than IHA (37%), P<0.001. However, the presence of copper alone cannot be used as a feature to differentiate between FNH and IHA.

AB - AIMS: To examine copper deposition in focal nodular hyperplasia (FNH) and inflammatory hepatocellular adenoma (IHA) and to determine if it can play a role in their differentiation.METHODS: 28 FNHs and 19 IHAs from surgical resections showing typical morphological and immunohistochemical features were stained with rhodanine to evaluate for copper deposition. Histological features such as nodularity, fibrous bands, ductular proliferation, steatosis, ballooned hepatocytes and lymphocytic inflammation were also scored.RESULTS: Copper deposition was detected in 96% (27/28) of FNHs and 37% (7/19) of IHAs, P<0.001. In all cases, copper was seen within the hepatocytes only around the pseudo-portal tracts or areas of fibrosis. Copper deposition in IHA was significantly associated with presence of lymphocytic inflammation (P=0.04) but not associated with features like nodularity, fibrous bands, ductular proliferation, ballooned hepatocytes and steatosis (P>0.05, for all). In FNH, the presence and degree of copper deposition was not significantly associated with any histological features (P>0.05, for all).CONCLUSIONS: Copper deposition occurs more frequently in FNH (96%) than IHA (37%), P<0.001. However, the presence of copper alone cannot be used as a feature to differentiate between FNH and IHA.

KW - histopathology

KW - liver

KW - staining

UR - http://www.scopus.com/inward/record.url?scp=85047906883&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85047906883&partnerID=8YFLogxK

U2 - 10.1136/jclinpath-2017-204820

DO - 10.1136/jclinpath-2017-204820

M3 - Article

C2 - 29127141

AN - SCOPUS:85047906883

VL - 71

SP - 504

EP - 507

JO - Molecular pathology : MP

JF - Molecular pathology : MP

SN - 0021-9746

IS - 6

ER -