Converting cancer genes into killer genes

Luis T. Da Costa, Jin Jen, Tong Chuan He, Timothy A. Chan, Kenneth W. Kinzler, Bert Vogelstein

Research output: Contribution to journalArticlepeer-review

46 Scopus citations

Abstract

Over the past decade, it has become clear that tumorigenesis is driven by alterations in genes that control cell growth or cell death. Theoretically, the proteins encoded by these genes provide excellent targets for new therapeutic agents. Here, we describe a gene therapy approach to specifically kill tumor cells expressing such oncoproteins. In outline, the target oncoprotein binds to exogenously introduced gene products, resulting in transcriptional activation of a toxic gene. As an example, we show that this approach can be used to specifically kill cells overexpressing a mutant p53 gene in cell culture. The strategy may be generally applicable to neoplastic diseases in which the underlying patterns of genetic alterations or abnormal gene expression are known.

Original languageEnglish (US)
Pages (from-to)4192-4196
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume93
Issue number9
DOIs
StatePublished - Apr 30 1996

Keywords

  • gene therapy
  • oncogene
  • p53
  • tumor suppressor gene

ASJC Scopus subject areas

  • General

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