Conversions between monotherapies in epilepsy: Expert consensus

Erik K. St. Louis; Barry E. Gidal; Thomas R. Henry; Yevgenya Kaydanova; Allan Krumholz; Paul H. McCabe; Georgia D. Montouris; William E. Rosenfeld; Brien J. Smith; John M. Stern; Elizabeth J. Waterhouse; Richard M. Schulz; William R. Garnett; Thomas Bramley

doi:10.1016/j.yebeh.2007.04.007

Conversions between monotherapies in epilepsy: Expert consensus

Erik K. St. Louis, Barry E. Gidal, Thomas R. Henry, Yevgenya Kaydanova, Allan Krumholz, Paul H. McCabe, Georgia D. Montouris, William E. Rosenfeld, Brien J. Smith, John M. Stern, Elizabeth J. Waterhouse, Richard M. Schulz, William R. Garnett, Thomas Bramley

Neurology

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

To develop expert consensus for conversion between antiepileptic drug (AED) monotherapies, an 11-member panel used the Delphi Technique over three rounds to: (1) identify relevant issues, (2) vote on the issues, and (3) develop consensus. The panel agreed on the basic principle to taper the existing AED only after a presumably efficacious dose of the planned AED was reached. Application is modified by adverse effects possibly attributable to the existing drug, in which case earlier or more rapid tapering of the existing drug should be considered. Patients with uncontrolled seizures, as well as seizure-free patients for whom driving privileges are a consideration, may benefit from slower tapering by smaller dosage decrements of the existing AED. For 10 of the 12 AEDs considered, the panel made titration recommendations concerning initial and target doses for the planned AED, supplementing limited data in the prescribing information. This expert guidance will aid in the period of transitional polytherapy with AEDs from monotherapy to monotherapy.

Original language	English (US)
Pages (from-to)	222-234
Number of pages	13
Journal	Epilepsy and Behavior
Volume	11
Issue number	2
DOIs	https://doi.org/10.1016/j.yebeh.2007.04.007
State	Published - Sep 2007

Keywords

Antiepileptic drugs
Conversion
Delphi Technique
Epilepsy
Expert opinion
Monotherapy
Polytherapy

ASJC Scopus subject areas

Neurology
Clinical Neurology
Behavioral Neuroscience

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10.1016/j.yebeh.2007.04.007

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St. Louis, E. K., Gidal, B. E., Henry, T. R., Kaydanova, Y., Krumholz, A., McCabe, P. H., Montouris, G. D., Rosenfeld, W. E., Smith, B. J., Stern, J. M., Waterhouse, E. J., Schulz, R. M., Garnett, W. R., & Bramley, T. (2007). Conversions between monotherapies in epilepsy: Expert consensus. Epilepsy and Behavior, 11(2), 222-234. https://doi.org/10.1016/j.yebeh.2007.04.007

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abstract = "To develop expert consensus for conversion between antiepileptic drug (AED) monotherapies, an 11-member panel used the Delphi Technique over three rounds to: (1) identify relevant issues, (2) vote on the issues, and (3) develop consensus. The panel agreed on the basic principle to taper the existing AED only after a presumably efficacious dose of the planned AED was reached. Application is modified by adverse effects possibly attributable to the existing drug, in which case earlier or more rapid tapering of the existing drug should be considered. Patients with uncontrolled seizures, as well as seizure-free patients for whom driving privileges are a consideration, may benefit from slower tapering by smaller dosage decrements of the existing AED. For 10 of the 12 AEDs considered, the panel made titration recommendations concerning initial and target doses for the planned AED, supplementing limited data in the prescribing information. This expert guidance will aid in the period of transitional polytherapy with AEDs from monotherapy to monotherapy.",

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author = "{St. Louis}, {Erik K.} and Gidal, {Barry E.} and Henry, {Thomas R.} and Yevgenya Kaydanova and Allan Krumholz and McCabe, {Paul H.} and Montouris, {Georgia D.} and Rosenfeld, {William E.} and Smith, {Brien J.} and Stern, {John M.} and Waterhouse, {Elizabeth J.} and Schulz, {Richard M.} and Garnett, {William R.} and Thomas Bramley",

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Conversions between monotherapies in epilepsy: Expert consensus

Abstract

Keywords

ASJC Scopus subject areas

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