Conversions between monotherapies in epilepsy: Expert consensus

Erik K. St. Louis, Barry E. Gidal, Thomas R. Henry, Yevgenya Kaydanova, Allan Krumholz, Paul H. McCabe, Georgia D. Montouris, William E. Rosenfeld, Brien J. Smith, John M. Stern, Elizabeth J. Waterhouse, Richard M. Schulz, William R. Garnett, Thomas Bramley

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

To develop expert consensus for conversion between antiepileptic drug (AED) monotherapies, an 11-member panel used the Delphi Technique over three rounds to: (1) identify relevant issues, (2) vote on the issues, and (3) develop consensus. The panel agreed on the basic principle to taper the existing AED only after a presumably efficacious dose of the planned AED was reached. Application is modified by adverse effects possibly attributable to the existing drug, in which case earlier or more rapid tapering of the existing drug should be considered. Patients with uncontrolled seizures, as well as seizure-free patients for whom driving privileges are a consideration, may benefit from slower tapering by smaller dosage decrements of the existing AED. For 10 of the 12 AEDs considered, the panel made titration recommendations concerning initial and target doses for the planned AED, supplementing limited data in the prescribing information. This expert guidance will aid in the period of transitional polytherapy with AEDs from monotherapy to monotherapy.

Original languageEnglish (US)
Pages (from-to)222-234
Number of pages13
JournalEpilepsy and Behavior
Volume11
Issue number2
DOIs
StatePublished - Sep 1 2007

Keywords

  • Antiepileptic drugs
  • Conversion
  • Delphi Technique
  • Epilepsy
  • Expert opinion
  • Monotherapy
  • Polytherapy

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Behavioral Neuroscience

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  • Cite this

    St. Louis, E. K., Gidal, B. E., Henry, T. R., Kaydanova, Y., Krumholz, A., McCabe, P. H., Montouris, G. D., Rosenfeld, W. E., Smith, B. J., Stern, J. M., Waterhouse, E. J., Schulz, R. M., Garnett, W. R., & Bramley, T. (2007). Conversions between monotherapies in epilepsy: Expert consensus. Epilepsy and Behavior, 11(2), 222-234. https://doi.org/10.1016/j.yebeh.2007.04.007