Convenient synthesis of a library of discrete hydroxamic acids using the hydroxythiophenol (Marshall) resin

Jinil Choi; Jewn Giew Park; Yuan Ping Pang

doi:10.1016/j.tetlet.2007.12.073

Convenient synthesis of a library of discrete hydroxamic acids using the hydroxythiophenol (Marshall) resin

Jinil Choi, Jewn Giew Park, Yuan Ping Pang

Pharmacology

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Several resins have reportedly been used to synthesize hydroxamic acids except for the hydroxythiophenol (Marshall) resin. Herein, we report the use of the Marshall resin to synthesize hydroxamic acids from carboxylic acids and its application to convert a library of 14 discrete aliphatic and aromatic carboxylic acids including N-protected amino acids to their corresponding hydroxamic acids in good yields.

Original language	English (US)
Pages (from-to)	1103-1106
Number of pages	4
Journal	Tetrahedron Letters
Volume	49
Issue number	7
DOIs	https://doi.org/10.1016/j.tetlet.2007.12.073
State	Published - Feb 11 2008

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2007.12.073

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abstract = "Several resins have reportedly been used to synthesize hydroxamic acids except for the hydroxythiophenol (Marshall) resin. Herein, we report the use of the Marshall resin to synthesize hydroxamic acids from carboxylic acids and its application to convert a library of 14 discrete aliphatic and aromatic carboxylic acids including N-protected amino acids to their corresponding hydroxamic acids in good yields.",

author = "Jinil Choi and Park, {Jewn Giew} and Pang, {Yuan Ping}",

note = "Funding Information: This work was supported by the US Army Medical Research Acquisition Activity (W81XWH-04-2-0001) and the National Institutes of Health/National Institute of Allergy and Infectious Diseases (5R01AI054574-03). The opinions or assertions contained herein belong to the authors and are not necessarily the official views of the US Army or the US National Institutes of Health.",

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AU - Pang, Yuan Ping

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N2 - Several resins have reportedly been used to synthesize hydroxamic acids except for the hydroxythiophenol (Marshall) resin. Herein, we report the use of the Marshall resin to synthesize hydroxamic acids from carboxylic acids and its application to convert a library of 14 discrete aliphatic and aromatic carboxylic acids including N-protected amino acids to their corresponding hydroxamic acids in good yields.

AB - Several resins have reportedly been used to synthesize hydroxamic acids except for the hydroxythiophenol (Marshall) resin. Herein, we report the use of the Marshall resin to synthesize hydroxamic acids from carboxylic acids and its application to convert a library of 14 discrete aliphatic and aromatic carboxylic acids including N-protected amino acids to their corresponding hydroxamic acids in good yields.

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Convenient synthesis of a library of discrete hydroxamic acids using the hydroxythiophenol (Marshall) resin

Abstract

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