Controversies in the Therapy of Low-Grade Gliomas

Ivan D. Carabenciov, Jan Craig Buckner

Research output: Contribution to journalReview article

1 Scopus citations


In the context of the new WHO classification system, all low-grade gliomas must have an IDH mutation, with or without 1p/19q codeletion. Upon discovery of the tumor, maximal safe surgical resection is the most appropriate first step due to the current inability to differentiate between IDH mutant and IDH wild–type tumors by imaging alone. In the postoperative setting, based on the synthesis and interpretation of the available data, we recommend utilizing conventional radiation therapy and PCV in all high-risk–low-grade gliomas. For patients felt to be in a low risk category, we recommend maintaining a low threshold to initiate treatment. In the setting of tumor recurrence, consideration of all treatment options is reasonable, but treatment with alkylator therapy has the strongest supporting data.

Original languageEnglish (US)
Article number25
JournalCurrent treatment options in oncology
Issue number4
StatePublished - Apr 1 2019



  • Controversy
  • IDH mutation
  • Low-grade glioma
  • PCV
  • Temozolomide

ASJC Scopus subject areas

  • Oncology
  • Pharmacology (medical)

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