@article{e353b5f8ae004f94877a8838c5e80cc8,
title = "Contributions of imprecision in PET-MRI rigid registration to imprecision in amyloid PET SUVR measurements",
abstract = "Quantitative measurement of β-amyloid from amyloid PET scans typically relies on localizing target and reference regions by image registration to MRI. In this work, we present a series of simulations where 50 small random perturbations of starting location and orientation were applied to each subject{\textquoteright}s PET scan, and rigid registration using spm_coreg was performed between each perturbed PET scan and its corresponding MRI. We then measured variation in the output PET-MRI registrations and how this variation affected the resulting SUVR measurements. We performed these experiments using scans of 1196 participants, half using 18F florbetapir and half using 11C PiB. From these experiments, we measured the magnitude of the imprecision in the rigid registration steps used to localize measurement regions, and how this contributes to the overall imprecision in SUVR measurements. Unexpectedly, we found for both tracers that the imprecision in these measurements depends on the degree of amyloid tracer uptake, and thus also indirectly on Alzheimer{\textquoteright}s disease clinical status. We then examined common choices of reference regions, and we show that SUVR measurements using supratentorial white matter references are relatively resistant to this source of error. We also show that the use of partial volume correction further magnifies the effects of registration imprecision on SUVR measurements. Together, these results suggest that this rigid registration step is an attractive target for future work in improving measurement techniques.",
keywords = "Alzheimer disease, Amyloid, Computer-assisted, Florbetapir, Image processing, Pittsburgh compound B, Positron-emission tomography, Reproducibility of results",
author = "{Alzheimer{\textquoteright}s Disease Neuroimaging Initiative} and Schwarz, {Christopher G.} and Jones, {David T.} and Gunter, {Jeffrey L.} and Lowe, {Val J.} and Prashanthi Vemuri and Senjem, {Matthew L.} and Petersen, {Ronald C.} and Knopman, {David S.} and Jack, {Clifford R.}",
note = "Funding Information: Contract grant sponsor: NIH grants; Contract grant number: R01 AG011378, R00 AG37573, R01 AG041851, U01 AG24904, U01 AG06786, P50 AG16574, R01 AG034676; Contract grant sponsor: The Alexander Family Professorship of Alzheimer?s Disease Research, Mayo Clinic; the GHR Foundation; Contract grant sponsor: Elsie and Marvin Dekelboum Family Foundation Funding Information: The authors would like to thank Heather J. Wiste for her assistance in selecting subjects for inclusion in this analysis. Data collection and sharing for the ADNI dataset used in this project was funded by the Alzheimer{\textquoteright}s Disease Neuroimaging Initiative (ADNI) (National Institutes of Health Grant U01 AG024904) and DOD ADNI (Department of Defense award number W81XWH-12-2-0012). ADNI is funded by the National Institute on Aging, the National Institute of Biomedical Imaging and Bioengineering, and through generous contributions from the following: AbbVie, Alzheimer{\textquoteright}s Association; Alzheimer{\textquoteright}s Drug Discovery Foundation; Araclon Biotech; BioClinica, Inc.; Biogen; Bristol-Myers Squibb Company; CereSpir, Inc.; Eisai Inc.; Elan Pharmaceuticals, Inc.; Eli Lilly and Company; EuroImmun; F. Hoffmann-La Roche Ltd and its affiliated company Genentech, Inc.; Fujirebio; GE Healthcare; IXICO Ltd.; Janssen Alzheimer Immunotherapy Research & Development, LLC.; Johnson & Johnson Pharmaceutical Research & Development LLC.; Lumosity; Lundbeck; Merck & Co., Inc.; Meso Scale Diagnostics, LLC.; NeuroRx Research; Neurotrack Technologies; Novar-tis Pharmaceuticals Corporation; Pfizer Inc.; Piramal Imaging; Servier; Takeda Pharmaceutical Company; and Transition Therapeutics. The Canadian Institutes of Health Research is providing funds to support ADNI clinical sites in Canada. Private sector contributions are facilitated by the Foundation for the National Institutes of Health (www.fnih.org). The grantee organization is the Northern California Institute for Research and Education, and the study is coordinated by the Alzheimer{\textquoteright}s Disease Cooperative Study at the University of California, San Diego. ADNI data are disseminated by the Laboratory for Neuro Imaging at the University of Southern California. Funding Information: Additional Supporting Information may be found in the online version of this article. The Alzheimer{\textquoteright}s Disease Neuroimaging Initiative: A portion of data used in preparation of this article were obtained from the Alzheimer{\textquoteright}s Disease Neuroimaging Initiative (ADNI) database (adni.loni.usc.edu). As such, the investigators within the ADNI contributed to the design and implementation of ADNI and/or provided data but did not participate in analysis or writing of this report. A complete listing of ADNI investigators can be found at: http://adni.loni.usc.edu/wp-content/uploads/how_to_ apply/ADNI_Acknowledgement_List.pdf. Contract grant sponsor: NIH grants; Contract grant number: R01 AG011378, R00 AG37573, R01 AG041851, U01 AG24904, U01 AG06786, P50 AG16574, R01 AG034676; Contract grant sponsor: The Alexander Family Professorship of Alzheimer{\textquoteright}s Disease Research, Mayo Clinic; the GHR Foundation; Contract grant sponsor: Elsie and Marvin Dekelboum Family Foundation *Correspondence to: Christopher G. Schwarz, Ph.D., Mayo Clinic, Diagnostic Radiology, 200 First Street SW, Rochester, MN, 55905. E-mail: schwarz.christopher@mayo.edu Received for publication 7 December 2016; Revised 6 April 2017; Accepted 9 April 2017. DOI: 10.1002/hbm.23622 Published online 22 April 2017 in Wiley Online Library (wileyon-linelibrary.com). Publisher Copyright: {\textcopyright} 2017 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc.",
year = "2017",
doi = "10.1002/hbm.23622",
language = "English (US)",
volume = "38",
pages = "3323--3336",
journal = "Human Brain Mapping",
issn = "1065-9471",
publisher = "Wiley-Liss Inc.",
number = "7",
}