Contribution of triglyceride-rich lipoproteins to plasma free fatty acids

J. M. Miles, R. H. Nelson

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Free fatty acids are the major lipid fuel of the body. Dysregulation of adipose tissue lipolysis results in increased plasma free fatty acid concentrations, and via that mechanism contributes to insulin resistance in obesity and type 2 diabetes mellitus. Adipose tissue hormone sensitive lipase is thought to be responsible for the production of the majority of free fatty acids. However, a separate contribution comes from the action of endothelial lipases, especially lipoprotein lipase, on triglyceride-rich lipoproteins via a process known as spillover. The primary substrate for spillover appears to be chylomicrons derived from dietary fat. The spillover of fatty acids into the free fatty acid pool varies from one tissue to another. For example, spillover is low (∼14%) in the forearm of healthy volunteers, suggesting that triglyceride fatty acid storage is relatively efficient in skeletal muscle. In contrast, spillover appears to be higher in adipose tissue and may also be higher in the splanchnic bed, based on preliminary data. If systemic spillover is increased in insulin resistant states such as diabetes, this could represent a mechanism contributing to the abnormal increases in plasma concentrations of free fatty acids in that condition.

Original languageEnglish (US)
Pages (from-to)726-729
Number of pages4
JournalHormone and Metabolic Research
Volume39
Issue number10
DOIs
StatePublished - Oct 2007

Fingerprint

Nonesterified Fatty Acids
Lipoproteins
Triglycerides
Plasmas
Tissue
Adipose Tissue
Medical problems
Fatty Acids
Insulin
Sterol Esterase
Chylomicrons
Viscera
Lipoprotein Lipase
Lipolysis
Dietary Fats
Lipases
Lipase
Forearm
Type 2 Diabetes Mellitus
Muscle

Keywords

  • Chylomicrons
  • FFA
  • Kinetics

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

Cite this

Contribution of triglyceride-rich lipoproteins to plasma free fatty acids. / Miles, J. M.; Nelson, R. H.

In: Hormone and Metabolic Research, Vol. 39, No. 10, 10.2007, p. 726-729.

Research output: Contribution to journalArticle

Miles, J. M. ; Nelson, R. H. / Contribution of triglyceride-rich lipoproteins to plasma free fatty acids. In: Hormone and Metabolic Research. 2007 ; Vol. 39, No. 10. pp. 726-729.
@article{9b9992f7995c4a74b5d910f7c76eac3e,
title = "Contribution of triglyceride-rich lipoproteins to plasma free fatty acids",
abstract = "Free fatty acids are the major lipid fuel of the body. Dysregulation of adipose tissue lipolysis results in increased plasma free fatty acid concentrations, and via that mechanism contributes to insulin resistance in obesity and type 2 diabetes mellitus. Adipose tissue hormone sensitive lipase is thought to be responsible for the production of the majority of free fatty acids. However, a separate contribution comes from the action of endothelial lipases, especially lipoprotein lipase, on triglyceride-rich lipoproteins via a process known as spillover. The primary substrate for spillover appears to be chylomicrons derived from dietary fat. The spillover of fatty acids into the free fatty acid pool varies from one tissue to another. For example, spillover is low (∼14{\%}) in the forearm of healthy volunteers, suggesting that triglyceride fatty acid storage is relatively efficient in skeletal muscle. In contrast, spillover appears to be higher in adipose tissue and may also be higher in the splanchnic bed, based on preliminary data. If systemic spillover is increased in insulin resistant states such as diabetes, this could represent a mechanism contributing to the abnormal increases in plasma concentrations of free fatty acids in that condition.",
keywords = "Chylomicrons, FFA, Kinetics",
author = "Miles, {J. M.} and Nelson, {R. H.}",
year = "2007",
month = "10",
doi = "10.1055/s-2007-990273",
language = "English (US)",
volume = "39",
pages = "726--729",
journal = "Hormone and Metabolic Research",
issn = "0018-5043",
publisher = "Georg Thieme Verlag",
number = "10",

}

TY - JOUR

T1 - Contribution of triglyceride-rich lipoproteins to plasma free fatty acids

AU - Miles, J. M.

AU - Nelson, R. H.

PY - 2007/10

Y1 - 2007/10

N2 - Free fatty acids are the major lipid fuel of the body. Dysregulation of adipose tissue lipolysis results in increased plasma free fatty acid concentrations, and via that mechanism contributes to insulin resistance in obesity and type 2 diabetes mellitus. Adipose tissue hormone sensitive lipase is thought to be responsible for the production of the majority of free fatty acids. However, a separate contribution comes from the action of endothelial lipases, especially lipoprotein lipase, on triglyceride-rich lipoproteins via a process known as spillover. The primary substrate for spillover appears to be chylomicrons derived from dietary fat. The spillover of fatty acids into the free fatty acid pool varies from one tissue to another. For example, spillover is low (∼14%) in the forearm of healthy volunteers, suggesting that triglyceride fatty acid storage is relatively efficient in skeletal muscle. In contrast, spillover appears to be higher in adipose tissue and may also be higher in the splanchnic bed, based on preliminary data. If systemic spillover is increased in insulin resistant states such as diabetes, this could represent a mechanism contributing to the abnormal increases in plasma concentrations of free fatty acids in that condition.

AB - Free fatty acids are the major lipid fuel of the body. Dysregulation of adipose tissue lipolysis results in increased plasma free fatty acid concentrations, and via that mechanism contributes to insulin resistance in obesity and type 2 diabetes mellitus. Adipose tissue hormone sensitive lipase is thought to be responsible for the production of the majority of free fatty acids. However, a separate contribution comes from the action of endothelial lipases, especially lipoprotein lipase, on triglyceride-rich lipoproteins via a process known as spillover. The primary substrate for spillover appears to be chylomicrons derived from dietary fat. The spillover of fatty acids into the free fatty acid pool varies from one tissue to another. For example, spillover is low (∼14%) in the forearm of healthy volunteers, suggesting that triglyceride fatty acid storage is relatively efficient in skeletal muscle. In contrast, spillover appears to be higher in adipose tissue and may also be higher in the splanchnic bed, based on preliminary data. If systemic spillover is increased in insulin resistant states such as diabetes, this could represent a mechanism contributing to the abnormal increases in plasma concentrations of free fatty acids in that condition.

KW - Chylomicrons

KW - FFA

KW - Kinetics

UR - http://www.scopus.com/inward/record.url?scp=36048992887&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=36048992887&partnerID=8YFLogxK

U2 - 10.1055/s-2007-990273

DO - 10.1055/s-2007-990273

M3 - Article

C2 - 17952834

AN - SCOPUS:36048992887

VL - 39

SP - 726

EP - 729

JO - Hormone and Metabolic Research

JF - Hormone and Metabolic Research

SN - 0018-5043

IS - 10

ER -