Abstract
We have previously shown that upper-body adipose tissue is more lipolytically active than lower-body adipose tissue in lean and obese women. The present studies were conducted to determine whether these regional differences are also present in men. Twenty-five lean, healthy men and 24 lean, healthy women underwent measures of body composition, postabsorptive systemic free fatty acid (FFA) flux, and leg and splanchnic FFA uptake and release. Upper-body adipose tissue was more lipolytically active than lower- body adipose tissue in both men (53.4 ± 32.2 v 26.6 ± 12.9 μmol · kg fat-1 · min-1, p < .001, respectively) and women (41.2 ± 22.3 v 16.4 ± 8.2 μmol · kg fat-1 · min-1, p < .001, respectively). The correlations between leg FFA release and systemic FFA flux were modest in women and men (r = .38, P = .07 and r = .56, P = .003, respectively) as were the correlations between splanchnic FFA release and systemic FFA flux (r = .41, P = .06 and r = .40, P = .07, respectively). No effect of gender on the relationship between leg or splanchnic FFA release and systemic FFA flux was detected. In summary, upper-body FFA release is greater than lower-body FFA release in both men and women, and the relationship between leg or splanchnic FFA release and systemic FFA release is weak and similar in men and women. These findings suggest that regional differences in postabsorptive FFA kinetics are unlikely to be responsible for differences in regional fat distribution.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 662-666 |
| Number of pages | 5 |
| Journal | Metabolism: Clinical and Experimental |
| Volume | 45 |
| Issue number | 5 |
| DOIs | |
| State | Published - 1996 |
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ASJC Scopus subject areas
- Endocrinology
- Endocrinology, Diabetes and Metabolism
Cite this
Contribution of leg and splanchnic free fatty acid (FFA) kinetics to postabsorptive FFA flux in men and women. / Jensen, Michael Dennis; Johnson, C. Michael.
In: Metabolism: Clinical and Experimental, Vol. 45, No. 5, 1996, p. 662-666.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Contribution of leg and splanchnic free fatty acid (FFA) kinetics to postabsorptive FFA flux in men and women
AU - Jensen, Michael Dennis
AU - Johnson, C. Michael
PY - 1996
Y1 - 1996
N2 - We have previously shown that upper-body adipose tissue is more lipolytically active than lower-body adipose tissue in lean and obese women. The present studies were conducted to determine whether these regional differences are also present in men. Twenty-five lean, healthy men and 24 lean, healthy women underwent measures of body composition, postabsorptive systemic free fatty acid (FFA) flux, and leg and splanchnic FFA uptake and release. Upper-body adipose tissue was more lipolytically active than lower- body adipose tissue in both men (53.4 ± 32.2 v 26.6 ± 12.9 μmol · kg fat-1 · min-1, p < .001, respectively) and women (41.2 ± 22.3 v 16.4 ± 8.2 μmol · kg fat-1 · min-1, p < .001, respectively). The correlations between leg FFA release and systemic FFA flux were modest in women and men (r = .38, P = .07 and r = .56, P = .003, respectively) as were the correlations between splanchnic FFA release and systemic FFA flux (r = .41, P = .06 and r = .40, P = .07, respectively). No effect of gender on the relationship between leg or splanchnic FFA release and systemic FFA flux was detected. In summary, upper-body FFA release is greater than lower-body FFA release in both men and women, and the relationship between leg or splanchnic FFA release and systemic FFA release is weak and similar in men and women. These findings suggest that regional differences in postabsorptive FFA kinetics are unlikely to be responsible for differences in regional fat distribution.
AB - We have previously shown that upper-body adipose tissue is more lipolytically active than lower-body adipose tissue in lean and obese women. The present studies were conducted to determine whether these regional differences are also present in men. Twenty-five lean, healthy men and 24 lean, healthy women underwent measures of body composition, postabsorptive systemic free fatty acid (FFA) flux, and leg and splanchnic FFA uptake and release. Upper-body adipose tissue was more lipolytically active than lower- body adipose tissue in both men (53.4 ± 32.2 v 26.6 ± 12.9 μmol · kg fat-1 · min-1, p < .001, respectively) and women (41.2 ± 22.3 v 16.4 ± 8.2 μmol · kg fat-1 · min-1, p < .001, respectively). The correlations between leg FFA release and systemic FFA flux were modest in women and men (r = .38, P = .07 and r = .56, P = .003, respectively) as were the correlations between splanchnic FFA release and systemic FFA flux (r = .41, P = .06 and r = .40, P = .07, respectively). No effect of gender on the relationship between leg or splanchnic FFA release and systemic FFA flux was detected. In summary, upper-body FFA release is greater than lower-body FFA release in both men and women, and the relationship between leg or splanchnic FFA release and systemic FFA release is weak and similar in men and women. These findings suggest that regional differences in postabsorptive FFA kinetics are unlikely to be responsible for differences in regional fat distribution.
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UR - http://www.scopus.com/inward/citedby.url?scp=0029912427&partnerID=8YFLogxK
U2 - 10.1016/S0026-0495(96)90040-2
DO - 10.1016/S0026-0495(96)90040-2
M3 - Article
VL - 45
SP - 662
EP - 666
JO - Metabolism: Clinical and Experimental
JF - Metabolism: Clinical and Experimental
SN - 0026-0495
IS - 5
ER -