Contrast optimization of fluid‐attenuated inversion recovery (flair) imaging

Research output: Contribution to journalArticlepeer-review

108 Scopus citations


The optimization of contrast is considered for the fluid‐attenuated inversion recovery (FLAIR) MRI pulse sequence, specifically the contrast of multiple sclerosis (MS) to white matter (WM). A performance bound is identified at 1.5 Tesla as that provided using an inversion time (TI) of 2900 ms. It is shown that TR/TI times exceeding 11000/2600 ms provide about 90% of the MS‐WM contrast possible theoretically. The commonly reported TR/TI combination of 6000/2000 provides only about 60%. For TR times exceeding 8000 ms, an echo time (TE) of 140 ms is at or near optimum. Use of TR/TI times less than 9000/2400 lacks efficiency in multisection imaging. Predicted relative contrast performance of TR/TI 11000/2600 versus 6000/2000 was evaluated in seven patients with known MS lesions, and measurements closely matched theoretical predictions. It is strongly recommended that for near optimum contrast and high multisection efficiency, FLAIR should be performed with TR/TI times exceeding 10000/2500 ms.

Original languageEnglish (US)
Pages (from-to)868-877
Number of pages10
JournalMagnetic Resonance in Medicine
Issue number6
StatePublished - Dec 1995


  • T‐weighted imaging
  • brain MRI
  • multiple sclerosis

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


Dive into the research topics of 'Contrast optimization of fluid‐attenuated inversion recovery (flair) imaging'. Together they form a unique fingerprint.

Cite this