Contrast-induced nephropathy in outpatients with preexisting renal impairment

a comparison between intravenous iohexol and iodixanol

Joseph G. Cernigliaro, William E Haley, Doug P. Adolphson, Maria A. Jepperson, Juliana Crook, Colleen S. Thomas, Alexander Parker

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background Concern for contrast-induced nephropathy (CIN) may result in administration of more costly agents. We prospectively compared outpatient CIN incidence of iodixanol to iohexol. Methods Patients were randomized to receive 100 ml of iohexol (n = 47) or iodixanol (n = 55). We compared patients who developed CIN using the Wilson score interval and also calculated an odds ratio for the development of CIN. Results CIN rate for iohexol was 2% compared to 9% for iodixanol. Those receiving iodixanol were almost 5 times more likely to experience CIN. Conclusion These results do not suggest a benefit of iodixanol over iohexol in the study population.

Original languageEnglish (US)
Pages (from-to)902-906
Number of pages5
JournalClinical Imaging
Volume40
Issue number5
DOIs
StatePublished - 2016

Fingerprint

Iohexol
Outpatients
Kidney
Odds Ratio
iodixanol
Incidence
Population

Keywords

  • Contrast nephropathy (CIN)
  • Iodixanol
  • Iohexol
  • Outpatient

ASJC Scopus subject areas

  • Medicine(all)
  • Radiology Nuclear Medicine and imaging

Cite this

Contrast-induced nephropathy in outpatients with preexisting renal impairment : a comparison between intravenous iohexol and iodixanol. / Cernigliaro, Joseph G.; Haley, William E; Adolphson, Doug P.; Jepperson, Maria A.; Crook, Juliana; Thomas, Colleen S.; Parker, Alexander.

In: Clinical Imaging, Vol. 40, No. 5, 2016, p. 902-906.

Research output: Contribution to journalArticle

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AU - Adolphson, Doug P.

AU - Jepperson, Maria A.

AU - Crook, Juliana

AU - Thomas, Colleen S.

AU - Parker, Alexander

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AB - Background Concern for contrast-induced nephropathy (CIN) may result in administration of more costly agents. We prospectively compared outpatient CIN incidence of iodixanol to iohexol. Methods Patients were randomized to receive 100 ml of iohexol (n = 47) or iodixanol (n = 55). We compared patients who developed CIN using the Wilson score interval and also calculated an odds ratio for the development of CIN. Results CIN rate for iohexol was 2% compared to 9% for iodixanol. Those receiving iodixanol were almost 5 times more likely to experience CIN. Conclusion These results do not suggest a benefit of iodixanol over iohexol in the study population.

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