Contrast-Enhanced Digital Mammography in the Surgical Management of Breast Cancer

Mariam Ali-Mucheru, Barbara A Pockaj, Bhavika Patel, Victor Pizzitola, Nabil Wasif, Chee Chee Stucky, Richard Gray

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: Contrast-enhanced digital mammography (CEDM) is a new breast imaging technique. The role of CEDM in the surgical management of breast cancer has not yet been characterized. Methods: A retrospective review of prospective breast surgery and breast imaging databases for patients who underwent CEDM and had breast cancer surgery. Results: A total of 351 patients had CEDM; 128 had malignant lesions, and 101 of these underwent surgery with 105 malignancies identified. The mean age was 62 years (range 25–85 years). The histology was 65 % invasive ductal carcinoma, 16 % invasive lobular carcinoma, 11 % ductal carcinoma-in situ, 3 % mixed invasive ductal carcinoma/invasive lobular carcinoma, and 5 % other histologies. After excluding two lesions that had been removed before the examination, CEDM identified 98 % (n = 101/103) of the index lesions. The two lesions not identified were Paget disease only and a parasternal lesion too medial to include in the field of view. CEDM led to additional biopsies in 12 % (n = 12) of patients. Of these, 67 % (n = 8) proved to be invasive carcinoma and 33 % (n = 4) were benign. CEDM changed surgical management in 20 % (n = 20) of cancer patients with a 4 % (n = 4) rate of conversion to mastectomy. Conclusions: Among patients undergoing surgical therapy for breast cancer, CEDM was highly sensitive, had size measurements that correlated well with histologic size, and produced a relatively low rate of false-positive additional biopsy findings. CEDM appears to be promising as an alternative to magnetic resonance imaging in the surgical planning of these patients.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalAnnals of Surgical Oncology
DOIs
StateAccepted/In press - Sep 15 2016

Fingerprint

Mammography
Breast Neoplasms
Lobular Carcinoma
Ductal Carcinoma
Breast
Histology
Biopsy
Carcinoma, Intraductal, Noninfiltrating
Mastectomy
Neoplasms
Magnetic Resonance Imaging
Databases
Carcinoma

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Contrast-Enhanced Digital Mammography in the Surgical Management of Breast Cancer. / Ali-Mucheru, Mariam; Pockaj, Barbara A; Patel, Bhavika; Pizzitola, Victor; Wasif, Nabil; Stucky, Chee Chee; Gray, Richard.

In: Annals of Surgical Oncology, 15.09.2016, p. 1-7.

Research output: Contribution to journalArticle

@article{c1a98e737c924f92ac1a5cedfb9cd098,
title = "Contrast-Enhanced Digital Mammography in the Surgical Management of Breast Cancer",
abstract = "Background: Contrast-enhanced digital mammography (CEDM) is a new breast imaging technique. The role of CEDM in the surgical management of breast cancer has not yet been characterized. Methods: A retrospective review of prospective breast surgery and breast imaging databases for patients who underwent CEDM and had breast cancer surgery. Results: A total of 351 patients had CEDM; 128 had malignant lesions, and 101 of these underwent surgery with 105 malignancies identified. The mean age was 62 years (range 25–85 years). The histology was 65 {\%} invasive ductal carcinoma, 16 {\%} invasive lobular carcinoma, 11 {\%} ductal carcinoma-in situ, 3 {\%} mixed invasive ductal carcinoma/invasive lobular carcinoma, and 5 {\%} other histologies. After excluding two lesions that had been removed before the examination, CEDM identified 98 {\%} (n = 101/103) of the index lesions. The two lesions not identified were Paget disease only and a parasternal lesion too medial to include in the field of view. CEDM led to additional biopsies in 12 {\%} (n = 12) of patients. Of these, 67 {\%} (n = 8) proved to be invasive carcinoma and 33 {\%} (n = 4) were benign. CEDM changed surgical management in 20 {\%} (n = 20) of cancer patients with a 4 {\%} (n = 4) rate of conversion to mastectomy. Conclusions: Among patients undergoing surgical therapy for breast cancer, CEDM was highly sensitive, had size measurements that correlated well with histologic size, and produced a relatively low rate of false-positive additional biopsy findings. CEDM appears to be promising as an alternative to magnetic resonance imaging in the surgical planning of these patients.",
author = "Mariam Ali-Mucheru and Pockaj, {Barbara A} and Bhavika Patel and Victor Pizzitola and Nabil Wasif and Stucky, {Chee Chee} and Richard Gray",
year = "2016",
month = "9",
day = "15",
doi = "10.1245/s10434-016-5567-7",
language = "English (US)",
pages = "1--7",
journal = "Annals of Surgical Oncology",
issn = "1068-9265",
publisher = "Springer New York",

}

TY - JOUR

T1 - Contrast-Enhanced Digital Mammography in the Surgical Management of Breast Cancer

AU - Ali-Mucheru, Mariam

AU - Pockaj, Barbara A

AU - Patel, Bhavika

AU - Pizzitola, Victor

AU - Wasif, Nabil

AU - Stucky, Chee Chee

AU - Gray, Richard

PY - 2016/9/15

Y1 - 2016/9/15

N2 - Background: Contrast-enhanced digital mammography (CEDM) is a new breast imaging technique. The role of CEDM in the surgical management of breast cancer has not yet been characterized. Methods: A retrospective review of prospective breast surgery and breast imaging databases for patients who underwent CEDM and had breast cancer surgery. Results: A total of 351 patients had CEDM; 128 had malignant lesions, and 101 of these underwent surgery with 105 malignancies identified. The mean age was 62 years (range 25–85 years). The histology was 65 % invasive ductal carcinoma, 16 % invasive lobular carcinoma, 11 % ductal carcinoma-in situ, 3 % mixed invasive ductal carcinoma/invasive lobular carcinoma, and 5 % other histologies. After excluding two lesions that had been removed before the examination, CEDM identified 98 % (n = 101/103) of the index lesions. The two lesions not identified were Paget disease only and a parasternal lesion too medial to include in the field of view. CEDM led to additional biopsies in 12 % (n = 12) of patients. Of these, 67 % (n = 8) proved to be invasive carcinoma and 33 % (n = 4) were benign. CEDM changed surgical management in 20 % (n = 20) of cancer patients with a 4 % (n = 4) rate of conversion to mastectomy. Conclusions: Among patients undergoing surgical therapy for breast cancer, CEDM was highly sensitive, had size measurements that correlated well with histologic size, and produced a relatively low rate of false-positive additional biopsy findings. CEDM appears to be promising as an alternative to magnetic resonance imaging in the surgical planning of these patients.

AB - Background: Contrast-enhanced digital mammography (CEDM) is a new breast imaging technique. The role of CEDM in the surgical management of breast cancer has not yet been characterized. Methods: A retrospective review of prospective breast surgery and breast imaging databases for patients who underwent CEDM and had breast cancer surgery. Results: A total of 351 patients had CEDM; 128 had malignant lesions, and 101 of these underwent surgery with 105 malignancies identified. The mean age was 62 years (range 25–85 years). The histology was 65 % invasive ductal carcinoma, 16 % invasive lobular carcinoma, 11 % ductal carcinoma-in situ, 3 % mixed invasive ductal carcinoma/invasive lobular carcinoma, and 5 % other histologies. After excluding two lesions that had been removed before the examination, CEDM identified 98 % (n = 101/103) of the index lesions. The two lesions not identified were Paget disease only and a parasternal lesion too medial to include in the field of view. CEDM led to additional biopsies in 12 % (n = 12) of patients. Of these, 67 % (n = 8) proved to be invasive carcinoma and 33 % (n = 4) were benign. CEDM changed surgical management in 20 % (n = 20) of cancer patients with a 4 % (n = 4) rate of conversion to mastectomy. Conclusions: Among patients undergoing surgical therapy for breast cancer, CEDM was highly sensitive, had size measurements that correlated well with histologic size, and produced a relatively low rate of false-positive additional biopsy findings. CEDM appears to be promising as an alternative to magnetic resonance imaging in the surgical planning of these patients.

UR - http://www.scopus.com/inward/record.url?scp=84988442703&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84988442703&partnerID=8YFLogxK

U2 - 10.1245/s10434-016-5567-7

DO - 10.1245/s10434-016-5567-7

M3 - Article

SP - 1

EP - 7

JO - Annals of Surgical Oncology

JF - Annals of Surgical Oncology

SN - 1068-9265

ER -