Contralateral adrenal metastasis of renal cell carcinoma: Treatment, outcome and a review

W. K. Lau, H. Zincke, C. M. Lohse, J. C. Cheville, A. L. Weaver, M. L. Blute

Research output: Contribution to journalReview article

54 Citations (Scopus)

Abstract

OBJECTIVE: To report the surgical treatment of patients with renal cell carcinoma (RCC) metastatic to the contralateral adrenal gland and compare our experience with previous reports, as such metastases are found in 2.5% of patients with metastatic RCC at autopsy, and the role of resecting metastatic RCC at this site is not well defined. PATIENTS AND METHODS: We retrospectively identified 11 patients who had surgery for metastatic RCC to the contralateral adrenal gland between October 1978 and April 2001. The patients' medical records were reviewed for clinical, surgical and pathological features, and the patients' outcome. RESULTS: The mean (median, range) age of the patients at primary nephrectomy was 60.9 (64, 43-79) years; all had clear cell (conventional) RCC. Synchronous contralateral adrenal metastasis occurred in two patients. The mean (median, range) time to contralateral adrenal metastasis after primary nephrectomy for the remaining nine patients was 5.2 (6.1, 0.8-9.2) years. All patients were treated with adrenalectomy; there were no perioperative complications or mortality. Seven patients died from RCC at a mean (median, range) of 3.9 (3.7, 0.2-10) years after adrenalectomy for contralateral adrenal metastasis; one died from other causes at 3.4 years, one from an unknown cause at 1.7 years and two were still alive at the last follow-up. CONCLUSIONS: The surgical resection of contralateral adrenal metastasis from RCC is safe; although most patients died from RCC, survival may be prolonged in individual patients. Hence, in the era of cytoreductive surgery, the removal of solitary contralateral adrenal metastasis seems to be indicated.

Original languageEnglish (US)
Pages (from-to)775-779
Number of pages5
JournalBJU International
Volume91
Issue number9
DOIs
StatePublished - Jun 2003

Fingerprint

Renal Cell Carcinoma
Neoplasm Metastasis
Adrenalectomy
Adrenal Glands
Nephrectomy
Naphazoline
Medical Records
Autopsy
Cell Survival

Keywords

  • Adrenal metastasis
  • Contralateral
  • Outcome
  • RCC
  • Renal cell carcinoma

ASJC Scopus subject areas

  • Urology

Cite this

Lau, W. K., Zincke, H., Lohse, C. M., Cheville, J. C., Weaver, A. L., & Blute, M. L. (2003). Contralateral adrenal metastasis of renal cell carcinoma: Treatment, outcome and a review. BJU International, 91(9), 775-779. https://doi.org/10.1046/j.1464-410X.2003.04237.x

Contralateral adrenal metastasis of renal cell carcinoma : Treatment, outcome and a review. / Lau, W. K.; Zincke, H.; Lohse, C. M.; Cheville, J. C.; Weaver, A. L.; Blute, M. L.

In: BJU International, Vol. 91, No. 9, 06.2003, p. 775-779.

Research output: Contribution to journalReview article

Lau, WK, Zincke, H, Lohse, CM, Cheville, JC, Weaver, AL & Blute, ML 2003, 'Contralateral adrenal metastasis of renal cell carcinoma: Treatment, outcome and a review', BJU International, vol. 91, no. 9, pp. 775-779. https://doi.org/10.1046/j.1464-410X.2003.04237.x
Lau, W. K. ; Zincke, H. ; Lohse, C. M. ; Cheville, J. C. ; Weaver, A. L. ; Blute, M. L. / Contralateral adrenal metastasis of renal cell carcinoma : Treatment, outcome and a review. In: BJU International. 2003 ; Vol. 91, No. 9. pp. 775-779.
@article{7647b4ad88bc466b94ab887153309e7b,
title = "Contralateral adrenal metastasis of renal cell carcinoma: Treatment, outcome and a review",
abstract = "OBJECTIVE: To report the surgical treatment of patients with renal cell carcinoma (RCC) metastatic to the contralateral adrenal gland and compare our experience with previous reports, as such metastases are found in 2.5{\%} of patients with metastatic RCC at autopsy, and the role of resecting metastatic RCC at this site is not well defined. PATIENTS AND METHODS: We retrospectively identified 11 patients who had surgery for metastatic RCC to the contralateral adrenal gland between October 1978 and April 2001. The patients' medical records were reviewed for clinical, surgical and pathological features, and the patients' outcome. RESULTS: The mean (median, range) age of the patients at primary nephrectomy was 60.9 (64, 43-79) years; all had clear cell (conventional) RCC. Synchronous contralateral adrenal metastasis occurred in two patients. The mean (median, range) time to contralateral adrenal metastasis after primary nephrectomy for the remaining nine patients was 5.2 (6.1, 0.8-9.2) years. All patients were treated with adrenalectomy; there were no perioperative complications or mortality. Seven patients died from RCC at a mean (median, range) of 3.9 (3.7, 0.2-10) years after adrenalectomy for contralateral adrenal metastasis; one died from other causes at 3.4 years, one from an unknown cause at 1.7 years and two were still alive at the last follow-up. CONCLUSIONS: The surgical resection of contralateral adrenal metastasis from RCC is safe; although most patients died from RCC, survival may be prolonged in individual patients. Hence, in the era of cytoreductive surgery, the removal of solitary contralateral adrenal metastasis seems to be indicated.",
keywords = "Adrenal metastasis, Contralateral, Outcome, RCC, Renal cell carcinoma",
author = "Lau, {W. K.} and H. Zincke and Lohse, {C. M.} and Cheville, {J. C.} and Weaver, {A. L.} and Blute, {M. L.}",
year = "2003",
month = "6",
doi = "10.1046/j.1464-410X.2003.04237.x",
language = "English (US)",
volume = "91",
pages = "775--779",
journal = "BJU International",
issn = "1464-4096",
publisher = "Wiley-Blackwell",
number = "9",

}

TY - JOUR

T1 - Contralateral adrenal metastasis of renal cell carcinoma

T2 - Treatment, outcome and a review

AU - Lau, W. K.

AU - Zincke, H.

AU - Lohse, C. M.

AU - Cheville, J. C.

AU - Weaver, A. L.

AU - Blute, M. L.

PY - 2003/6

Y1 - 2003/6

N2 - OBJECTIVE: To report the surgical treatment of patients with renal cell carcinoma (RCC) metastatic to the contralateral adrenal gland and compare our experience with previous reports, as such metastases are found in 2.5% of patients with metastatic RCC at autopsy, and the role of resecting metastatic RCC at this site is not well defined. PATIENTS AND METHODS: We retrospectively identified 11 patients who had surgery for metastatic RCC to the contralateral adrenal gland between October 1978 and April 2001. The patients' medical records were reviewed for clinical, surgical and pathological features, and the patients' outcome. RESULTS: The mean (median, range) age of the patients at primary nephrectomy was 60.9 (64, 43-79) years; all had clear cell (conventional) RCC. Synchronous contralateral adrenal metastasis occurred in two patients. The mean (median, range) time to contralateral adrenal metastasis after primary nephrectomy for the remaining nine patients was 5.2 (6.1, 0.8-9.2) years. All patients were treated with adrenalectomy; there were no perioperative complications or mortality. Seven patients died from RCC at a mean (median, range) of 3.9 (3.7, 0.2-10) years after adrenalectomy for contralateral adrenal metastasis; one died from other causes at 3.4 years, one from an unknown cause at 1.7 years and two were still alive at the last follow-up. CONCLUSIONS: The surgical resection of contralateral adrenal metastasis from RCC is safe; although most patients died from RCC, survival may be prolonged in individual patients. Hence, in the era of cytoreductive surgery, the removal of solitary contralateral adrenal metastasis seems to be indicated.

AB - OBJECTIVE: To report the surgical treatment of patients with renal cell carcinoma (RCC) metastatic to the contralateral adrenal gland and compare our experience with previous reports, as such metastases are found in 2.5% of patients with metastatic RCC at autopsy, and the role of resecting metastatic RCC at this site is not well defined. PATIENTS AND METHODS: We retrospectively identified 11 patients who had surgery for metastatic RCC to the contralateral adrenal gland between October 1978 and April 2001. The patients' medical records were reviewed for clinical, surgical and pathological features, and the patients' outcome. RESULTS: The mean (median, range) age of the patients at primary nephrectomy was 60.9 (64, 43-79) years; all had clear cell (conventional) RCC. Synchronous contralateral adrenal metastasis occurred in two patients. The mean (median, range) time to contralateral adrenal metastasis after primary nephrectomy for the remaining nine patients was 5.2 (6.1, 0.8-9.2) years. All patients were treated with adrenalectomy; there were no perioperative complications or mortality. Seven patients died from RCC at a mean (median, range) of 3.9 (3.7, 0.2-10) years after adrenalectomy for contralateral adrenal metastasis; one died from other causes at 3.4 years, one from an unknown cause at 1.7 years and two were still alive at the last follow-up. CONCLUSIONS: The surgical resection of contralateral adrenal metastasis from RCC is safe; although most patients died from RCC, survival may be prolonged in individual patients. Hence, in the era of cytoreductive surgery, the removal of solitary contralateral adrenal metastasis seems to be indicated.

KW - Adrenal metastasis

KW - Contralateral

KW - Outcome

KW - RCC

KW - Renal cell carcinoma

UR - http://www.scopus.com/inward/record.url?scp=0038649953&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0038649953&partnerID=8YFLogxK

U2 - 10.1046/j.1464-410X.2003.04237.x

DO - 10.1046/j.1464-410X.2003.04237.x

M3 - Review article

C2 - 12780830

AN - SCOPUS:0038649953

VL - 91

SP - 775

EP - 779

JO - BJU International

JF - BJU International

SN - 1464-4096

IS - 9

ER -