Contraction of collagen gels seeded with tendon cells

M. Y. Chen; L. Jeng; Y. L. Sun; C. F. Zhao; M. E. Zobitz; S. L. Moran; P. C. Amadio; K. N. An

Contraction of collagen gels seeded with tendon cells

M. Y. Chen, L. Jeng, Y. L. Sun, C. F. Zhao, M. E. Zobitz, S. L. Moran, P. C. Amadio, K. N. An

Research output: Contribution to journal › Article › peer-review

Abstract

Knowledge of the adaptation of the soft tissue to mechanical factors and biomolecules would be essential to better understand the mechanism of tendon injury and to improve the outcome of tendon repair. The responses to these factors could be different for the distinct types of cells in the tendon: cells from the tendon sheath, fibroblasts from the epitenon surface, or fibroblasts from the internal endotenon. In this study, we examined the mechanical and histological characteristics of the rate of contraction of the collagen gel seeded with epitenon and endotenon fibroblasts. The rate of contraction and the mechanical property of the contracted construct depend on the gel concentration and also the treatment of TGF-β₁.

Original language	English (US)
Pages (from-to)	337-345
Number of pages	9
Journal	Biorheology
Volume	43
Issue number	3-4
State	Published - 2006

Keywords

Biomechanics
Cell culture
Fibroblast
Gel concentration
TGF-β
Tendon

ASJC Scopus subject areas

Physiology
Physiology (medical)

Cite this

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abstract = "Knowledge of the adaptation of the soft tissue to mechanical factors and biomolecules would be essential to better understand the mechanism of tendon injury and to improve the outcome of tendon repair. The responses to these factors could be different for the distinct types of cells in the tendon: cells from the tendon sheath, fibroblasts from the epitenon surface, or fibroblasts from the internal endotenon. In this study, we examined the mechanical and histological characteristics of the rate of contraction of the collagen gel seeded with epitenon and endotenon fibroblasts. The rate of contraction and the mechanical property of the contracted construct depend on the gel concentration and also the treatment of TGF-β1.",

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T1 - Contraction of collagen gels seeded with tendon cells

AU - Chen, M. Y.

AU - Jeng, L.

AU - Sun, Y. L.

AU - Zhao, C. F.

AU - Zobitz, M. E.

AU - Moran, S. L.

AU - Amadio, P. C.

AU - An, K. N.

PY - 2006

Y1 - 2006

N2 - Knowledge of the adaptation of the soft tissue to mechanical factors and biomolecules would be essential to better understand the mechanism of tendon injury and to improve the outcome of tendon repair. The responses to these factors could be different for the distinct types of cells in the tendon: cells from the tendon sheath, fibroblasts from the epitenon surface, or fibroblasts from the internal endotenon. In this study, we examined the mechanical and histological characteristics of the rate of contraction of the collagen gel seeded with epitenon and endotenon fibroblasts. The rate of contraction and the mechanical property of the contracted construct depend on the gel concentration and also the treatment of TGF-β1.

AB - Knowledge of the adaptation of the soft tissue to mechanical factors and biomolecules would be essential to better understand the mechanism of tendon injury and to improve the outcome of tendon repair. The responses to these factors could be different for the distinct types of cells in the tendon: cells from the tendon sheath, fibroblasts from the epitenon surface, or fibroblasts from the internal endotenon. In this study, we examined the mechanical and histological characteristics of the rate of contraction of the collagen gel seeded with epitenon and endotenon fibroblasts. The rate of contraction and the mechanical property of the contracted construct depend on the gel concentration and also the treatment of TGF-β1.

KW - Biomechanics

KW - Cell culture

KW - Fibroblast

KW - Gel concentration

KW - TGF-β

KW - Tendon

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JF - Biorheology

IS - 3-4

ER -

Contraction of collagen gels seeded with tendon cells

Abstract

Keywords

ASJC Scopus subject areas

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