Continuous neomycin production by immobilized cells of Streptomyces marinensis NUV-5 in an airlift bioreactor

K. Adinarayana; B. Srinivasulu; K. V.V.S.N. Bapi Raju; P. Ellaiah

doi:10.1016/S0032-9592(03)00271-1

Continuous neomycin production by immobilized cells of Streptomyces marinensis NUV-5 in an airlift bioreactor

K. Adinarayana, B. Srinivasulu, K. V.V.S.N. Bapi Raju, P. Ellaiah

Infectious Diseases

Research output: Contribution to journal › Article › peer-review

Abstract

Neomycin production by free and calcium alginate immobilized cells was investigated in an airlift reactor. The average volumetric productivity with continuous fermentation (72.97 mg/l/h) was greater than with free cells (45.05 mg/l/h). The total neomycin produced with continuous fermentation was 62% greater than with that of free cells. Immobilized Streptomyces particles showed a half-life of 42 days during continuous fermentation under airlift conditions.

Original language	English (US)
Pages (from-to)	1407-1414
Number of pages	8
Journal	Process Biochemistry
Volume	39
Issue number	11
DOIs	https://doi.org/10.1016/S0032-9592(03)00271-1
State	Published - Jul 30 2004

Keywords

Airlift reactor
Continuous fermentation
Neomycin
Streptomyces marinensis NUV-5

ASJC Scopus subject areas

Bioengineering
Biochemistry
Applied Microbiology and Biotechnology

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10.1016/S0032-9592(03)00271-1

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title = "Continuous neomycin production by immobilized cells of Streptomyces marinensis NUV-5 in an airlift bioreactor",

abstract = "Neomycin production by free and calcium alginate immobilized cells was investigated in an airlift reactor. The average volumetric productivity with continuous fermentation (72.97 mg/l/h) was greater than with free cells (45.05 mg/l/h). The total neomycin produced with continuous fermentation was 62% greater than with that of free cells. Immobilized Streptomyces particles showed a half-life of 42 days during continuous fermentation under airlift conditions.",

keywords = "Airlift reactor, Continuous fermentation, Neomycin, Streptomyces marinensis NUV-5",

author = "K. Adinarayana and B. Srinivasulu and {Bapi Raju}, {K. V.V.S.N.} and P. Ellaiah",

note = "Funding Information: The authors are thankful to Burrows Welcome (I) Limited, India, for proving pure neomycin sulphate. The authors are also thankful to University Grants Commission (UGC), New Delhi, for providing the financial support to carry out the research work.",

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AU - Adinarayana, K.

AU - Srinivasulu, B.

AU - Bapi Raju, K. V.V.S.N.

AU - Ellaiah, P.

N1 - Funding Information: The authors are thankful to Burrows Welcome (I) Limited, India, for proving pure neomycin sulphate. The authors are also thankful to University Grants Commission (UGC), New Delhi, for providing the financial support to carry out the research work.

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N2 - Neomycin production by free and calcium alginate immobilized cells was investigated in an airlift reactor. The average volumetric productivity with continuous fermentation (72.97 mg/l/h) was greater than with free cells (45.05 mg/l/h). The total neomycin produced with continuous fermentation was 62% greater than with that of free cells. Immobilized Streptomyces particles showed a half-life of 42 days during continuous fermentation under airlift conditions.

AB - Neomycin production by free and calcium alginate immobilized cells was investigated in an airlift reactor. The average volumetric productivity with continuous fermentation (72.97 mg/l/h) was greater than with free cells (45.05 mg/l/h). The total neomycin produced with continuous fermentation was 62% greater than with that of free cells. Immobilized Streptomyces particles showed a half-life of 42 days during continuous fermentation under airlift conditions.

KW - Airlift reactor

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KW - Neomycin

KW - Streptomyces marinensis NUV-5

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Continuous neomycin production by immobilized cells of Streptomyces marinensis NUV-5 in an airlift bioreactor

Abstract

Keywords

ASJC Scopus subject areas

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