TY - JOUR
T1 - Contingent gene regulatory networks and B cell fate specification
AU - Singh, Harinder
AU - Medina, Kay L.
AU - Pongubala, Jagan M.R.
PY - 2005/4/5
Y1 - 2005/4/5
N2 - The B cell developmental pathway represents a leading system for the analysis of regulatory circuits that orchestrate cell fate specification and commitment. Considerable progress has been achieved within the past decade in the identification and genetic analysis of various regulatory components. These components include the transcription factors PU.1, Ikaros, Bcl11a, E2A, EBF, and Pax-5, as well as the cytokine receptors Flk2 and IL-7R. Experimental evidence of connectivity among the regulatory components is used to assemble sequentially acting and contingent gene regulatory networks. Transient signaling inputs, self-sustaining positive feedback loops, and crossantagonism among alternate cell fate determinants are key features of the proposed networks that instruct the development of B lymphocyte precursors from hematopoietic stem cells.
AB - The B cell developmental pathway represents a leading system for the analysis of regulatory circuits that orchestrate cell fate specification and commitment. Considerable progress has been achieved within the past decade in the identification and genetic analysis of various regulatory components. These components include the transcription factors PU.1, Ikaros, Bcl11a, E2A, EBF, and Pax-5, as well as the cytokine receptors Flk2 and IL-7R. Experimental evidence of connectivity among the regulatory components is used to assemble sequentially acting and contingent gene regulatory networks. Transient signaling inputs, self-sustaining positive feedback loops, and crossantagonism among alternate cell fate determinants are key features of the proposed networks that instruct the development of B lymphocyte precursors from hematopoietic stem cells.
KW - B lymphopoiesis
KW - Cell fate determination
KW - Cytokine signaling
KW - Hematopoiesis
KW - Transcription factors
UR - http://www.scopus.com/inward/record.url?scp=17044440153&partnerID=8YFLogxK
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U2 - 10.1073/pnas.0500480102
DO - 10.1073/pnas.0500480102
M3 - Article
C2 - 15788530
AN - SCOPUS:17044440153
SN - 0027-8424
VL - 102
SP - 4949
EP - 4953
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 14
ER -