Contemporary radiotherapy and radiosurgery techniques for refractory pituitary adenomas

Roman O. Kowalchuk, Daniel M. Trifiletti, Paul D. Brown, Jason P. Sheehan

Research output: Contribution to journalArticlepeer-review


The pituitary gland is a potential site for a range of pathologies, for which treatment can involve resection and/or ionizing radiation. Modern stereotactic radiosurgery (SRS) involves highly conformal radiation, allowing for the delivery of high doses to the tumor while simultaneously sparing nearby healthy structures. SRS has become a standard treatment option for residual or recurrent pituitary adenomas. It has been used for both functioning and nonfunctioning pituitary adenomas, with reported local tumor control over 90% and moderate rates of endocrine remission in functioning adenomas. We aim to briefly review the existing indictions and supporting literature for the use of SRS for refractory adenomas.

Original languageEnglish (US)
StateAccepted/In press - 2023


  • Pituitary
  • Pituitary adenoma
  • Radiosurgery
  • SRS

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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