Contemporary consensus proposal on criteria and classification of eosinophilic disorders and related syndromes

Peter Valent, Amy D. Klion, Hans Peter Horny, Florence Roufosse, Jason Gotlib, Peter F. Weller, Andrzej Hellmann, Georgia Metzgeroth, Kristin M. Leiferman, Michel Arock, Joseph H. Butterfield, Wolfgang R. Sperr, Karl Sotlar, Peter Vandenberghe, Torsten Haferlach, Hans Uwe Simon, Andreas Reiter, Gerald J. Gleich

Research output: Contribution to journalArticle

274 Citations (Scopus)

Abstract

Eosinophilia is an important indicator of various neoplastic and nonneoplastic conditions. Depending on the underlying disease and mechanisms, eosinophil infiltration can lead to organ dysfunction, clinical symptoms, or both. During the past 2 decades, several different classifications of eosinophilic disorders and related syndromes have been proposed in various fields of medicine. Although criteria and definitions are, in part, overlapping, no global consensus has been presented to date. The Year 2011 Working Conference on Eosinophil Disorders and Syndromes was organized to update and refine the criteria and definitions for eosinophilic disorders and to merge prior classifications in a contemporary multidisciplinary schema. A panel of experts from the fields of immunology, allergy, hematology, and pathology contributed to this project. The expert group agreed on unifying terminologies and criteria and a classification that delineates various forms of hypereosinophilia, including primary and secondary variants based on specific hematologic and immunologic conditions, and various forms of the hypereosinophilic syndrome. For patients in whom no underlying disease or hypereosinophilic syndrome is found, the term hypereosinophilia of undetermined significance is introduced. The proposed novel criteria, definitions, and terminologies should assist in daily practice, as well as in the preparation and conduct of clinical trials.

Original languageEnglish (US)
JournalJournal of Allergy and Clinical Immunology
Volume130
Issue number3
DOIs
StatePublished - Sep 2012

Fingerprint

Hypereosinophilic Syndrome
Eosinophils
Terminology
Eosinophilia
Hematology
Allergy and Immunology
Medicine
Clinical Trials
Pathology

Keywords

  • classification
  • criteria
  • eosinophilic leukemia
  • hypereosinophilia of undetermined significance
  • Hypereosinophilic syndrome

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Contemporary consensus proposal on criteria and classification of eosinophilic disorders and related syndromes. / Valent, Peter; Klion, Amy D.; Horny, Hans Peter; Roufosse, Florence; Gotlib, Jason; Weller, Peter F.; Hellmann, Andrzej; Metzgeroth, Georgia; Leiferman, Kristin M.; Arock, Michel; Butterfield, Joseph H.; Sperr, Wolfgang R.; Sotlar, Karl; Vandenberghe, Peter; Haferlach, Torsten; Simon, Hans Uwe; Reiter, Andreas; Gleich, Gerald J.

In: Journal of Allergy and Clinical Immunology, Vol. 130, No. 3, 09.2012.

Research output: Contribution to journalArticle

Valent, P, Klion, AD, Horny, HP, Roufosse, F, Gotlib, J, Weller, PF, Hellmann, A, Metzgeroth, G, Leiferman, KM, Arock, M, Butterfield, JH, Sperr, WR, Sotlar, K, Vandenberghe, P, Haferlach, T, Simon, HU, Reiter, A & Gleich, GJ 2012, 'Contemporary consensus proposal on criteria and classification of eosinophilic disorders and related syndromes', Journal of Allergy and Clinical Immunology, vol. 130, no. 3. https://doi.org/10.1016/j.jaci.2012.02.019
Valent, Peter ; Klion, Amy D. ; Horny, Hans Peter ; Roufosse, Florence ; Gotlib, Jason ; Weller, Peter F. ; Hellmann, Andrzej ; Metzgeroth, Georgia ; Leiferman, Kristin M. ; Arock, Michel ; Butterfield, Joseph H. ; Sperr, Wolfgang R. ; Sotlar, Karl ; Vandenberghe, Peter ; Haferlach, Torsten ; Simon, Hans Uwe ; Reiter, Andreas ; Gleich, Gerald J. / Contemporary consensus proposal on criteria and classification of eosinophilic disorders and related syndromes. In: Journal of Allergy and Clinical Immunology. 2012 ; Vol. 130, No. 3.
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