TY - JOUR
T1 - Contemporary consensus proposal on criteria and classification of eosinophilic disorders and related syndromes
AU - Valent, Peter
AU - Klion, Amy D.
AU - Horny, Hans Peter
AU - Roufosse, Florence
AU - Gotlib, Jason
AU - Weller, Peter F.
AU - Hellmann, Andrzej
AU - Metzgeroth, Georgia
AU - Leiferman, Kristin M.
AU - Arock, Michel
AU - Butterfield, Joseph H.
AU - Sperr, Wolfgang R.
AU - Sotlar, Karl
AU - Vandenberghe, Peter
AU - Haferlach, Torsten
AU - Simon, Hans Uwe
AU - Reiter, Andreas
AU - Gleich, Gerald J.
PY - 2012/9
Y1 - 2012/9
N2 - Eosinophilia is an important indicator of various neoplastic and nonneoplastic conditions. Depending on the underlying disease and mechanisms, eosinophil infiltration can lead to organ dysfunction, clinical symptoms, or both. During the past 2 decades, several different classifications of eosinophilic disorders and related syndromes have been proposed in various fields of medicine. Although criteria and definitions are, in part, overlapping, no global consensus has been presented to date. The Year 2011 Working Conference on Eosinophil Disorders and Syndromes was organized to update and refine the criteria and definitions for eosinophilic disorders and to merge prior classifications in a contemporary multidisciplinary schema. A panel of experts from the fields of immunology, allergy, hematology, and pathology contributed to this project. The expert group agreed on unifying terminologies and criteria and a classification that delineates various forms of hypereosinophilia, including primary and secondary variants based on specific hematologic and immunologic conditions, and various forms of the hypereosinophilic syndrome. For patients in whom no underlying disease or hypereosinophilic syndrome is found, the term hypereosinophilia of undetermined significance is introduced. The proposed novel criteria, definitions, and terminologies should assist in daily practice, as well as in the preparation and conduct of clinical trials.
AB - Eosinophilia is an important indicator of various neoplastic and nonneoplastic conditions. Depending on the underlying disease and mechanisms, eosinophil infiltration can lead to organ dysfunction, clinical symptoms, or both. During the past 2 decades, several different classifications of eosinophilic disorders and related syndromes have been proposed in various fields of medicine. Although criteria and definitions are, in part, overlapping, no global consensus has been presented to date. The Year 2011 Working Conference on Eosinophil Disorders and Syndromes was organized to update and refine the criteria and definitions for eosinophilic disorders and to merge prior classifications in a contemporary multidisciplinary schema. A panel of experts from the fields of immunology, allergy, hematology, and pathology contributed to this project. The expert group agreed on unifying terminologies and criteria and a classification that delineates various forms of hypereosinophilia, including primary and secondary variants based on specific hematologic and immunologic conditions, and various forms of the hypereosinophilic syndrome. For patients in whom no underlying disease or hypereosinophilic syndrome is found, the term hypereosinophilia of undetermined significance is introduced. The proposed novel criteria, definitions, and terminologies should assist in daily practice, as well as in the preparation and conduct of clinical trials.
KW - Hypereosinophilic syndrome
KW - classification
KW - criteria
KW - eosinophilic leukemia
KW - hypereosinophilia of undetermined significance
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UR - http://www.scopus.com/inward/citedby.url?scp=84865701899&partnerID=8YFLogxK
U2 - 10.1016/j.jaci.2012.02.019
DO - 10.1016/j.jaci.2012.02.019
M3 - Article
C2 - 22460074
AN - SCOPUS:84865701899
SN - 0091-6749
VL - 130
SP - 607-612.e9
JO - Journal of Allergy and Clinical Immunology
JF - Journal of Allergy and Clinical Immunology
IS - 3
ER -