TY - JOUR
T1 - Contact sensitivities in palmar plantar pustulosis (acropustulosis)
AU - Yiannias, James A.
AU - Winkelmann, R. K.
AU - Connolly, Suzanne M.
PY - 1998
Y1 - 1998
N2 - Acropustulosis, or chronic palmar plantar pustulosis (PPP), is a phenomenon of recurrent sterile pustules, erythema, and scaling affecting the palms and soles. Its pathogenesis is unclear, and it is difficult to treat. The purpose of this study was to elucidate further the factors involved in causing PPP, thereby enhancing the ability to manage this disease. All cases of PPP seen at Mayo Clinic Scottsdale from 1987 to 1993 were reviewed. 21 patients with PPP were identified, 15 of whom had been patch tested. 9 of the 15 patients (60%) showed positive patch test results. Fragrance was the most common sensitivity, but nickel, formaldehyde, para-phenylenediamine, thiuram, neomycin, mercury, balsam of Peru, and cinnamic aldehyde sensitivities were demonstrated. Less important factors included atopy fungal and bacterial infections, and irritation. Although the mechanism of this sterile pustulosis response does not depend solely on delayed hypersensitivity mechanisms, we believe that we have demonstrated such a large number of positive patch tests in this chronic pustular dermatosis that patch testing should be considered in the routine work-up of these patients.
AB - Acropustulosis, or chronic palmar plantar pustulosis (PPP), is a phenomenon of recurrent sterile pustules, erythema, and scaling affecting the palms and soles. Its pathogenesis is unclear, and it is difficult to treat. The purpose of this study was to elucidate further the factors involved in causing PPP, thereby enhancing the ability to manage this disease. All cases of PPP seen at Mayo Clinic Scottsdale from 1987 to 1993 were reviewed. 21 patients with PPP were identified, 15 of whom had been patch tested. 9 of the 15 patients (60%) showed positive patch test results. Fragrance was the most common sensitivity, but nickel, formaldehyde, para-phenylenediamine, thiuram, neomycin, mercury, balsam of Peru, and cinnamic aldehyde sensitivities were demonstrated. Less important factors included atopy fungal and bacterial infections, and irritation. Although the mechanism of this sterile pustulosis response does not depend solely on delayed hypersensitivity mechanisms, we believe that we have demonstrated such a large number of positive patch tests in this chronic pustular dermatosis that patch testing should be considered in the routine work-up of these patients.
KW - Acropustulosis
KW - Contact dermatitis
KW - Fragrance
KW - Palmar plantar pustulosis
KW - Para-phenylenediamine
KW - Psoriasis
UR - http://www.scopus.com/inward/record.url?scp=0031689505&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031689505&partnerID=8YFLogxK
U2 - 10.1111/j.1600-0536.1998.tb05857.x
DO - 10.1111/j.1600-0536.1998.tb05857.x
M3 - Article
C2 - 9771982
AN - SCOPUS:0031689505
SN - 0105-1873
VL - 39
SP - 108
EP - 111
JO - Contact Dermatitis
JF - Contact Dermatitis
IS - 3
ER -