Contact sensitivities in palmar plantar pustulosis (acropustulosis)

James A. Yiannias, R. K. Winkelmann, Suzanne M. Connolly

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Acropustulosis, or chronic palmar plantar pustulosis (PPP), is a phenomenon of recurrent sterile pustules, erythema, and scaling affecting the palms and soles. Its pathogenesis is unclear, and it is difficult to treat. The purpose of this study was to elucidate further the factors involved in causing PPP, thereby enhancing the ability to manage this disease. All cases of PPP seen at Mayo Clinic Scottsdale from 1987 to 1993 were reviewed. 21 patients with PPP were identified, 15 of whom had been patch tested. 9 of the 15 patients (60%) showed positive patch test results. Fragrance was the most common sensitivity, but nickel, formaldehyde, para-phenylenediamine, thiuram, neomycin, mercury, balsam of Peru, and cinnamic aldehyde sensitivities were demonstrated. Less important factors included atopy fungal and bacterial infections, and irritation. Although the mechanism of this sterile pustulosis response does not depend solely on delayed hypersensitivity mechanisms, we believe that we have demonstrated such a large number of positive patch tests in this chronic pustular dermatosis that patch testing should be considered in the routine work-up of these patients.

Original languageEnglish (US)
Pages (from-to)108-111
Number of pages4
JournalContact Dermatitis
Volume39
Issue number3
DOIs
StatePublished - 1998

Fingerprint

Thiram
Fragrances
Neomycin
Contact Dermatitis
Nickel
Mercury
Formaldehyde
Patch Tests
Testing
Mycoses
Delayed Hypersensitivity
Erythema
Bacterial Infections
Skin Diseases
4-phenylenediamine
Peruvian balsam
cinnamic aldehyde

Keywords

  • Acropustulosis
  • Contact dermatitis
  • Fragrance
  • Palmar plantar pustulosis
  • Para-phenylenediamine
  • Psoriasis

ASJC Scopus subject areas

  • Dermatology
  • Toxicology
  • Immunology

Cite this

Contact sensitivities in palmar plantar pustulosis (acropustulosis). / Yiannias, James A.; Winkelmann, R. K.; Connolly, Suzanne M.

In: Contact Dermatitis, Vol. 39, No. 3, 1998, p. 108-111.

Research output: Contribution to journalArticle

Yiannias, James A. ; Winkelmann, R. K. ; Connolly, Suzanne M. / Contact sensitivities in palmar plantar pustulosis (acropustulosis). In: Contact Dermatitis. 1998 ; Vol. 39, No. 3. pp. 108-111.
@article{79cce6738fbc41e5a74f42ee5f9eef7a,
title = "Contact sensitivities in palmar plantar pustulosis (acropustulosis)",
abstract = "Acropustulosis, or chronic palmar plantar pustulosis (PPP), is a phenomenon of recurrent sterile pustules, erythema, and scaling affecting the palms and soles. Its pathogenesis is unclear, and it is difficult to treat. The purpose of this study was to elucidate further the factors involved in causing PPP, thereby enhancing the ability to manage this disease. All cases of PPP seen at Mayo Clinic Scottsdale from 1987 to 1993 were reviewed. 21 patients with PPP were identified, 15 of whom had been patch tested. 9 of the 15 patients (60{\%}) showed positive patch test results. Fragrance was the most common sensitivity, but nickel, formaldehyde, para-phenylenediamine, thiuram, neomycin, mercury, balsam of Peru, and cinnamic aldehyde sensitivities were demonstrated. Less important factors included atopy fungal and bacterial infections, and irritation. Although the mechanism of this sterile pustulosis response does not depend solely on delayed hypersensitivity mechanisms, we believe that we have demonstrated such a large number of positive patch tests in this chronic pustular dermatosis that patch testing should be considered in the routine work-up of these patients.",
keywords = "Acropustulosis, Contact dermatitis, Fragrance, Palmar plantar pustulosis, Para-phenylenediamine, Psoriasis",
author = "Yiannias, {James A.} and Winkelmann, {R. K.} and Connolly, {Suzanne M.}",
year = "1998",
doi = "10.1111/j.1600-0536.1998.tb05857.x",
language = "English (US)",
volume = "39",
pages = "108--111",
journal = "Contact Dermatitis",
issn = "0105-1873",
publisher = "Wiley-Blackwell",
number = "3",

}

TY - JOUR

T1 - Contact sensitivities in palmar plantar pustulosis (acropustulosis)

AU - Yiannias, James A.

AU - Winkelmann, R. K.

AU - Connolly, Suzanne M.

PY - 1998

Y1 - 1998

N2 - Acropustulosis, or chronic palmar plantar pustulosis (PPP), is a phenomenon of recurrent sterile pustules, erythema, and scaling affecting the palms and soles. Its pathogenesis is unclear, and it is difficult to treat. The purpose of this study was to elucidate further the factors involved in causing PPP, thereby enhancing the ability to manage this disease. All cases of PPP seen at Mayo Clinic Scottsdale from 1987 to 1993 were reviewed. 21 patients with PPP were identified, 15 of whom had been patch tested. 9 of the 15 patients (60%) showed positive patch test results. Fragrance was the most common sensitivity, but nickel, formaldehyde, para-phenylenediamine, thiuram, neomycin, mercury, balsam of Peru, and cinnamic aldehyde sensitivities were demonstrated. Less important factors included atopy fungal and bacterial infections, and irritation. Although the mechanism of this sterile pustulosis response does not depend solely on delayed hypersensitivity mechanisms, we believe that we have demonstrated such a large number of positive patch tests in this chronic pustular dermatosis that patch testing should be considered in the routine work-up of these patients.

AB - Acropustulosis, or chronic palmar plantar pustulosis (PPP), is a phenomenon of recurrent sterile pustules, erythema, and scaling affecting the palms and soles. Its pathogenesis is unclear, and it is difficult to treat. The purpose of this study was to elucidate further the factors involved in causing PPP, thereby enhancing the ability to manage this disease. All cases of PPP seen at Mayo Clinic Scottsdale from 1987 to 1993 were reviewed. 21 patients with PPP were identified, 15 of whom had been patch tested. 9 of the 15 patients (60%) showed positive patch test results. Fragrance was the most common sensitivity, but nickel, formaldehyde, para-phenylenediamine, thiuram, neomycin, mercury, balsam of Peru, and cinnamic aldehyde sensitivities were demonstrated. Less important factors included atopy fungal and bacterial infections, and irritation. Although the mechanism of this sterile pustulosis response does not depend solely on delayed hypersensitivity mechanisms, we believe that we have demonstrated such a large number of positive patch tests in this chronic pustular dermatosis that patch testing should be considered in the routine work-up of these patients.

KW - Acropustulosis

KW - Contact dermatitis

KW - Fragrance

KW - Palmar plantar pustulosis

KW - Para-phenylenediamine

KW - Psoriasis

UR - http://www.scopus.com/inward/record.url?scp=0031689505&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031689505&partnerID=8YFLogxK

U2 - 10.1111/j.1600-0536.1998.tb05857.x

DO - 10.1111/j.1600-0536.1998.tb05857.x

M3 - Article

C2 - 9771982

AN - SCOPUS:0031689505

VL - 39

SP - 108

EP - 111

JO - Contact Dermatitis

JF - Contact Dermatitis

SN - 0105-1873

IS - 3

ER -