Consult and procedure incidence outcomes following establishment of a fertility preservation program for children with cancer

Supriya Behl; Vidhu B. Joshi; Reda S. Hussein; David L. Walker; Kari L. Lampat; Anthony G. Krenik; Kathrynne M. Barud; Jolene R. Fredrickson; Terri M. Galanits; Katherine J. Rian; Adriana M. Delgado; Julia H. Byrne; Dean Potter; Siobhan T. Pittock; Carola A.S. Arndt; Yulian Zhao; Patricio C. Gargollo; Candace F. Granberg; Zaraq Khan; Asma J. Chattha

doi:10.1007/s10815-020-02042-8

Consult and procedure incidence outcomes following establishment of a fertility preservation program for children with cancer

Supriya Behl, Vidhu B. Joshi, Reda S. Hussein, David L. Walker, Kari L. Lampat, Anthony G. Krenik, Kathrynne M. Barud, Jolene R. Fredrickson, Terri M. Galanits, Katherine J. Rian, Adriana M. Delgado, Julia H. Byrne, Dean Potter, Siobhan T. Pittock, Carola A.S. Arndt, Yulian Zhao, Patricio C. Gargollo, Candace F. Granberg, Zaraq Khan, Asma J. Chattha

Pediatric and Adolescent Medicine

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Purpose: Fertility is a quality of life outcome adversely affected by cancer therapy. Many childhood cancer patients, however, are not offered options to preserve their fertility. Providers acknowledge difficulty discussing impaired fertility to patients due to lack of knowledge of available options. Our objective was to review the impact of a pediatric multidisciplinary fertility preservation program on providers’ fertility preservation counseling and discussion of options. Methods: A retrospective medical chart review was conducted for pediatric cancer patients prior to and following program establishment. Fertility preservation discussions, consults, and incidence were noted. Following filtering and stratification, 198 and 237 patients were seen prior to and following program establishment, respectively. Results: Following program establishment, provider–patient discussions of impaired fertility (p = 0.007), fertility preservation consults (p = 0.01), and incidence of fertility preservation procedures (p < 0.001) increased among patients. Furthermore, the number of patients who received fertility preservation consults after receiving gonadotoxic treatment decreased (p < 0.001). This trend was particularly noted in pre-pubertal and female patients, for whom fertility preservation options are limited without an established program. Conclusion: The establishment of a formal program greatly improved access to fertility preservation consults and procedures in children with cancer.

Original language	English (US)
Pages (from-to)	495-501
Number of pages	7
Journal	Journal of Assisted Reproduction and Genetics
Volume	38
Issue number	2
DOIs	https://doi.org/10.1007/s10815-020-02042-8
State	Published - Feb 2021

Keywords

Childhood cancer
Gonadotoxic treatment
Gynecology
Infertility
Pediatrics
Urology

ASJC Scopus subject areas

Reproductive Medicine
Genetics
Obstetrics and Gynecology
Developmental Biology
Genetics(clinical)

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10.1007/s10815-020-02042-8

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Behl, S., Joshi, V. B., Hussein, R. S., Walker, D. L., Lampat, K. L., Krenik, A. G., Barud, K. M., Fredrickson, J. R., Galanits, T. M., Rian, K. J., Delgado, A. M., Byrne, J. H., Potter, D., Pittock, S. T., Arndt, C. A. S., Zhao, Y., Gargollo, P. C., Granberg, C. F., Khan, Z., & Chattha, A. J. (2021). Consult and procedure incidence outcomes following establishment of a fertility preservation program for children with cancer. Journal of Assisted Reproduction and Genetics, 38(2), 495-501. https://doi.org/10.1007/s10815-020-02042-8

Behl, S, Joshi, VB, Hussein, RS, Walker, DL, Lampat, KL, Krenik, AG, Barud, KM, Fredrickson, JR, Galanits, TM, Rian, KJ, Delgado, AM, Byrne, JH, Potter, D, Pittock, ST, Arndt, CAS, Zhao, Y, Gargollo, PC, Granberg, CF, Khan, Z & Chattha, AJ 2021, 'Consult and procedure incidence outcomes following establishment of a fertility preservation program for children with cancer', Journal of Assisted Reproduction and Genetics, vol. 38, no. 2, pp. 495-501. https://doi.org/10.1007/s10815-020-02042-8

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title = "Consult and procedure incidence outcomes following establishment of a fertility preservation program for children with cancer",

abstract = "Purpose: Fertility is a quality of life outcome adversely affected by cancer therapy. Many childhood cancer patients, however, are not offered options to preserve their fertility. Providers acknowledge difficulty discussing impaired fertility to patients due to lack of knowledge of available options. Our objective was to review the impact of a pediatric multidisciplinary fertility preservation program on providers{\textquoteright} fertility preservation counseling and discussion of options. Methods: A retrospective medical chart review was conducted for pediatric cancer patients prior to and following program establishment. Fertility preservation discussions, consults, and incidence were noted. Following filtering and stratification, 198 and 237 patients were seen prior to and following program establishment, respectively. Results: Following program establishment, provider–patient discussions of impaired fertility (p = 0.007), fertility preservation consults (p = 0.01), and incidence of fertility preservation procedures (p < 0.001) increased among patients. Furthermore, the number of patients who received fertility preservation consults after receiving gonadotoxic treatment decreased (p < 0.001). This trend was particularly noted in pre-pubertal and female patients, for whom fertility preservation options are limited without an established program. Conclusion: The establishment of a formal program greatly improved access to fertility preservation consults and procedures in children with cancer.",

keywords = "Childhood cancer, Gonadotoxic treatment, Gynecology, Infertility, Pediatrics, Urology",

author = "Supriya Behl and Joshi, {Vidhu B.} and Hussein, {Reda S.} and Walker, {David L.} and Lampat, {Kari L.} and Krenik, {Anthony G.} and Barud, {Kathrynne M.} and Fredrickson, {Jolene R.} and Galanits, {Terri M.} and Rian, {Katherine J.} and Delgado, {Adriana M.} and Byrne, {Julia H.} and Dean Potter and Pittock, {Siobhan T.} and Arndt, {Carola A.S.} and Yulian Zhao and Gargollo, {Patricio C.} and Granberg, {Candace F.} and Zaraq Khan and Chattha, {Asma J.}",

note = "Publisher Copyright: {\textcopyright} 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature.",

year = "2021",

month = feb,

doi = "10.1007/s10815-020-02042-8",

language = "English (US)",

volume = "38",

pages = "495--501",

journal = "Journal of Assisted Reproduction and Genetics",

issn = "1058-0468",

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number = "2",

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TY - JOUR

T1 - Consult and procedure incidence outcomes following establishment of a fertility preservation program for children with cancer

AU - Behl, Supriya

AU - Joshi, Vidhu B.

AU - Hussein, Reda S.

AU - Walker, David L.

AU - Lampat, Kari L.

AU - Krenik, Anthony G.

AU - Barud, Kathrynne M.

AU - Fredrickson, Jolene R.

AU - Galanits, Terri M.

AU - Rian, Katherine J.

AU - Delgado, Adriana M.

AU - Byrne, Julia H.

AU - Potter, Dean

AU - Pittock, Siobhan T.

AU - Arndt, Carola A.S.

AU - Zhao, Yulian

AU - Gargollo, Patricio C.

AU - Granberg, Candace F.

AU - Khan, Zaraq

AU - Chattha, Asma J.

PY - 2021/2

Y1 - 2021/2

N2 - Purpose: Fertility is a quality of life outcome adversely affected by cancer therapy. Many childhood cancer patients, however, are not offered options to preserve their fertility. Providers acknowledge difficulty discussing impaired fertility to patients due to lack of knowledge of available options. Our objective was to review the impact of a pediatric multidisciplinary fertility preservation program on providers’ fertility preservation counseling and discussion of options. Methods: A retrospective medical chart review was conducted for pediatric cancer patients prior to and following program establishment. Fertility preservation discussions, consults, and incidence were noted. Following filtering and stratification, 198 and 237 patients were seen prior to and following program establishment, respectively. Results: Following program establishment, provider–patient discussions of impaired fertility (p = 0.007), fertility preservation consults (p = 0.01), and incidence of fertility preservation procedures (p < 0.001) increased among patients. Furthermore, the number of patients who received fertility preservation consults after receiving gonadotoxic treatment decreased (p < 0.001). This trend was particularly noted in pre-pubertal and female patients, for whom fertility preservation options are limited without an established program. Conclusion: The establishment of a formal program greatly improved access to fertility preservation consults and procedures in children with cancer.

AB - Purpose: Fertility is a quality of life outcome adversely affected by cancer therapy. Many childhood cancer patients, however, are not offered options to preserve their fertility. Providers acknowledge difficulty discussing impaired fertility to patients due to lack of knowledge of available options. Our objective was to review the impact of a pediatric multidisciplinary fertility preservation program on providers’ fertility preservation counseling and discussion of options. Methods: A retrospective medical chart review was conducted for pediatric cancer patients prior to and following program establishment. Fertility preservation discussions, consults, and incidence were noted. Following filtering and stratification, 198 and 237 patients were seen prior to and following program establishment, respectively. Results: Following program establishment, provider–patient discussions of impaired fertility (p = 0.007), fertility preservation consults (p = 0.01), and incidence of fertility preservation procedures (p < 0.001) increased among patients. Furthermore, the number of patients who received fertility preservation consults after receiving gonadotoxic treatment decreased (p < 0.001). This trend was particularly noted in pre-pubertal and female patients, for whom fertility preservation options are limited without an established program. Conclusion: The establishment of a formal program greatly improved access to fertility preservation consults and procedures in children with cancer.

KW - Childhood cancer

KW - Gonadotoxic treatment

KW - Gynecology

KW - Infertility

KW - Pediatrics

KW - Urology

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U2 - 10.1007/s10815-020-02042-8

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SN - 1058-0468

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EP - 501

JO - Journal of Assisted Reproduction and Genetics

JF - Journal of Assisted Reproduction and Genetics

IS - 2

ER -

Consult and procedure incidence outcomes following establishment of a fertility preservation program for children with cancer

Abstract

Keywords

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