Construction and characterization of a population-based cohort to study the association of anesthesia exposure with neurodevelopmental outcomes

Danqing Hu, Randall Flick, Stephen J. Gleich, Maura M. Scanlon, Michael J Zaccariello, Robert C. Colligan, Slavica K Katusic, Darrell R. Schroeder, Andrew C. Hanson, Shonie L. Buenvenida, Robert T. Wilder, Juraj Sprung, David Oman Warner

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Exposure to general anesthesia at an early age has been associated with adverse neurodevelopmental outcomes in both animal and human studies, but some of these studies employed anesthetic agents that are no longer in clinical use. In this manuscript, we describe the methods used to construct a new population-based study cohort to study the association between early anesthetic exposure and subsequent neurodevelopmental outcomes. A birth cohort of all children born in Olmsted County, MN from January 1, 1996 to December 31, 2000 was identified. For each, school enrollment status in the Independent School District (ISD) 535 at age 5 or 6 and all episodes of anesthetic exposure before age 3 were identified. A study cohort was created by matching children enrolled in ISD 535 based on the propensity of receiving general anesthesia. Three analyses were performed to characterize the study cohort by comparing the birth and parental information, comorbidities, and socioeconomic status. The first analysis compared the characteristics of birth cohort children who were and were not enrolled in ISD 535. The second analysis evaluated the success of the propensity matching schemes in creating groups of children that were similar in measured characteristics except for anesthesia exposure. The third analysis compared the characteristics of children with anesthesia exposures who were and were not included in the final cohort based on propensity matching. Results of these analyses demonstrate only slight differences among the comparison groups, and therefore these are unlikely to compromise our future analysis of anesthetic exposure and neurodevelopmental outcomes.

Original languageEnglish (US)
Article numbere0155288
JournalPLoS One
Volume11
Issue number5
DOIs
StatePublished - May 1 2016

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Anesthetics
anesthesia
Cohort Studies
Anesthesia
anesthetics
cohort studies
Population
Parturition
General Anesthesia
socioeconomic status
Animals
Social Class
Comorbidity
Students
animals
methodology

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Construction and characterization of a population-based cohort to study the association of anesthesia exposure with neurodevelopmental outcomes. / Hu, Danqing; Flick, Randall; Gleich, Stephen J.; Scanlon, Maura M.; Zaccariello, Michael J; Colligan, Robert C.; Katusic, Slavica K; Schroeder, Darrell R.; Hanson, Andrew C.; Buenvenida, Shonie L.; Wilder, Robert T.; Sprung, Juraj; Warner, David Oman.

In: PLoS One, Vol. 11, No. 5, e0155288, 01.05.2016.

Research output: Contribution to journalArticle

Hu, Danqing ; Flick, Randall ; Gleich, Stephen J. ; Scanlon, Maura M. ; Zaccariello, Michael J ; Colligan, Robert C. ; Katusic, Slavica K ; Schroeder, Darrell R. ; Hanson, Andrew C. ; Buenvenida, Shonie L. ; Wilder, Robert T. ; Sprung, Juraj ; Warner, David Oman. / Construction and characterization of a population-based cohort to study the association of anesthesia exposure with neurodevelopmental outcomes. In: PLoS One. 2016 ; Vol. 11, No. 5.
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