Constrictive pericarditis in chronic ulcerative colitis

Amy S. Oxentenko, Edward Vincent Loftus, Jr, Jae Kuen Oh, Gordon K. Danielson, Thomas F. Mangan

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Acute pericarditis has been described as an extraintestinal manifestation of inflammatory bowel disease (IBD), as well as a consequence of IBD treatment, specifically sulfasalazine and mesalamine. Until now, there have been no reported cases of constrictive pericarditis associated with IBD or its treatment. A 37-year-old woman with a 24-year history of chronic ulcerative colitis (CUC) presented with a 3-month history of fevers, palpitations, dyspnea, syncope, and retrosternal chest pain. Two weeks before symptoms, she had initiated oral mesalamine for an ongoing CUC flare. Physical examination suggested constrictive pericarditis. An echocardiogram revealed a thickened pericardium with a nearly circumferential fibrinous effusion, with Doppler confirming diastolic compromise. The patient proceeded to radical pericardectomy. Pathological examination showed grossly hemorrhagic acute and chronic pericarditis, with cultures and cytology negative. To date, only 104 cases of IBD with acute pericarditis have been reported, with fewer than 10 cases of mesalamine-induced acute pericarditis reported. This is the first reported case of constrictive pericarditis related to IBD or its treatment. Although our patient may have had IBD-associated constrictive pericarditis, her mesalamine use raises the possibility of a drug-induced constrictive pericarditis.

Original languageEnglish (US)
Pages (from-to)247-251
Number of pages5
JournalJournal of Clinical Gastroenterology
Volume34
Issue number3
DOIs
StatePublished - 2002

Fingerprint

Constrictive Pericarditis
Ulcerative Colitis
Inflammatory Bowel Diseases
Mesalamine
Pericarditis
Pericardiectomy
Sulfasalazine
Pericardium
Syncope
Chest Pain
Dyspnea
Physical Examination
Cell Biology
Fever
Therapeutics
Pharmaceutical Preparations

Keywords

  • Constrictive pericarditis
  • Mesalamine
  • Ulcerative colitis

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Constrictive pericarditis in chronic ulcerative colitis. / Oxentenko, Amy S.; Loftus, Jr, Edward Vincent; Oh, Jae Kuen; Danielson, Gordon K.; Mangan, Thomas F.

In: Journal of Clinical Gastroenterology, Vol. 34, No. 3, 2002, p. 247-251.

Research output: Contribution to journalArticle

Oxentenko, Amy S. ; Loftus, Jr, Edward Vincent ; Oh, Jae Kuen ; Danielson, Gordon K. ; Mangan, Thomas F. / Constrictive pericarditis in chronic ulcerative colitis. In: Journal of Clinical Gastroenterology. 2002 ; Vol. 34, No. 3. pp. 247-251.
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