TY - JOUR
T1 - Considering sex as a biological variable in preclinical research
AU - Miller, Leah R.
AU - Marks, Cheryl
AU - Becker, Jill B.
AU - Hurn, Patricia D.
AU - Chen, Wei Jung
AU - Woodruff, Teresa
AU - McCarthy, Margaret M.
AU - Sohrabji, Farida
AU - Schiebinger, Londa
AU - Lee Wetherington, Cora
AU - Makris, Susan
AU - Arnold, Arthur P.
AU - Einstein, Gillian
AU - Miller, Virginia M.
AU - Sandberg, Kathryn
AU - Maier, Susan
AU - Cornelison, Terri L.
AU - Clayton, Janine A.
N1 - Publisher Copyright:
© 2017 FASEB.
PY - 2017/1
Y1 - 2017/1
N2 - In June2015, the National Institutes of Health (NIH)released a Guidenotice (NOT-OD-15-102) that highlighted the expectation of the NIH that the possible role of sex as a biologicvariablebe factored into research design, analyses, and reporting of vertebrate animal and human studies. Anticipating these guidelines, the NIH Office of Research on Women's Health, in October 2014, convened key stakeholders to discuss methods and techniques for integrating sex as a biologic variable in preclinical research. The workshop focused on practical methods, experimental design, and approaches to statistical analyses in the use of both male and female animals, cells, and tissues in preclinical research. Workshop participants also considered gender as a modifier of biology. This article builds on the works hopandismeant as a guide to preclinical investigators as they consider methods and techniques for inclusion of both sexes in preclinical research and is not intended to prescribe exhaustive/specific approaches for compliance with the new NIH policy. -Miller, L. R., Marks, C., Becker, J.B., Hurn, P.D., Chen, W.-J., Woodruff, T., McCarthy, M.M., Sohrabji, F., Schiebinger, L., Wetherington, C.L., Makris, S., Arnold, A. P., Einstein, G., Miller, V. M., Sandberg, K., Maier, S., Cornelison, T. L., Clayton, J. A. Considering sex as a biological variable in preclinical research.
AB - In June2015, the National Institutes of Health (NIH)released a Guidenotice (NOT-OD-15-102) that highlighted the expectation of the NIH that the possible role of sex as a biologicvariablebe factored into research design, analyses, and reporting of vertebrate animal and human studies. Anticipating these guidelines, the NIH Office of Research on Women's Health, in October 2014, convened key stakeholders to discuss methods and techniques for integrating sex as a biologic variable in preclinical research. The workshop focused on practical methods, experimental design, and approaches to statistical analyses in the use of both male and female animals, cells, and tissues in preclinical research. Workshop participants also considered gender as a modifier of biology. This article builds on the works hopandismeant as a guide to preclinical investigators as they consider methods and techniques for inclusion of both sexes in preclinical research and is not intended to prescribe exhaustive/specific approaches for compliance with the new NIH policy. -Miller, L. R., Marks, C., Becker, J.B., Hurn, P.D., Chen, W.-J., Woodruff, T., McCarthy, M.M., Sohrabji, F., Schiebinger, L., Wetherington, C.L., Makris, S., Arnold, A. P., Einstein, G., Miller, V. M., Sandberg, K., Maier, S., Cornelison, T. L., Clayton, J. A. Considering sex as a biological variable in preclinical research.
KW - Gender
KW - Methods
KW - Sex differences
KW - Sex influences
UR - http://www.scopus.com/inward/record.url?scp=85009732706&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85009732706&partnerID=8YFLogxK
U2 - 10.1096/fj.201600781R
DO - 10.1096/fj.201600781R
M3 - Article
C2 - 27682203
AN - SCOPUS:85009732706
SN - 0892-6638
VL - 31
SP - 29
EP - 34
JO - FASEB Journal
JF - FASEB Journal
IS - 1
ER -