@article{331181368e514dacac7e09737efd77c6,
title = "Conserved brain myelination networks are altered in Alzheimer's and other neurodegenerative diseases",
abstract = "Introduction: Comparative transcriptome analyses in Alzheimer's disease (AD) and other neurodegenerative proteinopathies can uncover both shared and distinct disease pathways. Methods: We analyzed 940 brain transcriptomes including patients with AD, progressive supranuclear palsy (PSP; a primary tauopathy), and control subjects. Results: We identified transcriptional coexpression networks implicated in myelination, which were lower in PSP temporal cortex (TCX) compared with AD. Some of these associations were retained even after adjustments for brain cell population changes. These TCX myelination network structures were preserved in cerebellum but they were not differentially expressed in cerebellum between AD and PSP. Myelination networks were downregulated in both AD and PSP, when compared with control TCX samples. Discussion: Downregulation of myelination networks may underlie both PSP and AD pathophysiology, but may be more pronounced in PSP. These data also highlight conservation of transcriptional networks across brain regions and the influence of cell type changes on these networks.",
keywords = "Alzheimer's disease, Cerebellum, Coexpression networks, Myelination, Progressive supranuclear palsy, Proteinopathies, Temporal cortex, Transcriptome",
author = "Mariet Allen and Xue Wang and Burgess, {Jeremy D.} and Jens Watzlawik and Serie, {Daniel J.} and Younkin, {Curtis S.} and Thuy Nguyen and Malphrus, {Kimberly G.} and Sarah Lincoln and Carrasquillo, {Minerva M.} and Charlotte Ho and Paramita Chakrabarty and Samantha Strickland and Murray, {Melissa E.} and Vivek Swarup and Geschwind, {Daniel H.} and Seyfried, {Nicholas T.} and Dammer, {Eric B.} and Lah, {James J.} and Levey, {Allan I.} and Golde, {Todd E.} and Cory Funk and Hongdong Li and Price, {Nathan D.} and Petersen, {Ronald C.} and Graff-Radford, {Neill R.} and Younkin, {Steven G.} and Dickson, {Dennis W.} and Crook, {Julia R.} and Asmann, {Yan W.} and Nil{\"u}fer Ertekin-Taner",
note = "Funding Information: This work was supported by the National Institute on Aging [R01 AG032990, RF AG051504 to N.E.T.; U01 AG046139 to N.E.T. and S.G.Y.; P50 AG0016574 to D.W.D., N.E.T., N.R.G.-R., R.C.P., and S.G.Y.]; U01 AG006786 to R.C.P.; the National Institute of Neurological Disorders and Stroke [R01 NS080820 to N.E.T.]; the Mayo Clinic Center for Individualized Medicine [Gerstner Family Career Development Award to M.E.M.]. Funding Information: For samples collected through the Sun Health Research Institute Brain and Body Donation Program of Sun City, Arizona: The Brain and Body Donation Program is supported by the National Institute of Neurological Disorders and Stroke (U24 NS072026 National Brain and Tissue Resource for Parkinson's Disease and Related Disorders), the National Institute on Aging (P30 AG19610 Arizona Alzheimer's Disease Core Center), the Arizona Department of Health Services (contract 211002, Arizona Alzheimer's Research Center), the Arizona Biomedical Research Commission (contracts 4001, 0011, 05-901, and 1001 to the Arizona Parkinson's Disease Consortium), and the Michael J. Fox Foundation for Parkinson's Research. Publisher Copyright: {\textcopyright} 2017 The Authors",
year = "2018",
month = mar,
doi = "10.1016/j.jalz.2017.09.012",
language = "English (US)",
volume = "14",
pages = "352--366",
journal = "Alzheimer's and Dementia",
issn = "1552-5260",
publisher = "Elsevier Inc.",
number = "3",
}