Conservative treatment of hemolytic complication following coil embolization in two adult cases of patent ductus arteriosus

K. Eda, S. Ohtsuka, Y. Seo, S. Yamada, M. Ishiyama, T. Miyamoto, H. Horigome, I. Yamaguchi

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12 Scopus citations


Two adult cases of relatively large patent ductus arteriosus (PDA) were treated by coil embolization, but were complicated by hemolysis that was successfully managed by medical treatment. Case 1 was a 67-year-old woman and Case 2 was a 71-year-old woman with a PDA of minimal diameter of 5.3 mm and 5.5 mm, respectively. The approach was via the pulmonary artery and 2 coils were delivered simultaneously into the ductus, known as the 'kissing coil technique'. Although immediately after the procedure only a small residual shunt was revealed by aortogram, hemolysis occurred for several hours after the procedure in both cases. A hemolytic complication usually needs additional coil embolization or surgical treatment, but in these 2 cases it was successfully treated by haptoglobin infusion to prevent nephropathy and by antiplasmin infusion to promote thrombus formation. Hemolytic complications of coil embolization of PDA can managed by medication when the residual shunt is minimal and the degree of hemolysis is mild.

Original languageEnglish (US)
Pages (from-to)834-836
Number of pages3
JournalJapanese Circulation Journal
Issue number9
StatePublished - Sep 26 2001



  • Coil embolization
  • Hemolysis
  • Patent ductus arteriosus

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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