Conservation of pro-longevity genes among mammals

Carter M. Lindborg, Kathleen J. Propert, Robert Pignolo

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Genes which confer a relative longevity advantage may be regulated at the level of transcription or translation. Alternatively, pro-longevity genes may mediate their effects at the level of protein structure-functional relationships that are beneficially optimized in long-lived species. Longevity associated genes (LAGs) may be operationally defined as genes that confer beneficial effects and are relatively more conserved among long-lived species. Global and local protein sequence alignments of over 10,000 genes across at least 30 mammalian species were examined to identify LAGs. Known LAGs, including growth hormone receptor (GHR), and breast cancer 1, early onset (BRCA1), have strong associations with maximum lifespan by our analysis. Several common categories of protein function were observed among genes ranked with the strongest associations with MLS identified by all regression models. These genes included those that function in the immune system, cell cycle regulation, and DNA damage response. We provide a ranking of genes with the strongest associations with species maximum lifespan (MLS) by several phylogenetic generalized least squares regression models, including adjustment for confounding variables such as body weight and gestation length.

Original languageEnglish (US)
Pages (from-to)23-27
Number of pages5
JournalMechanisms of Ageing and Development
Volume146-148
DOIs
StatePublished - Mar 1 2015
Externally publishedYes

Fingerprint

Mammals
Genes
Somatotropin Receptors
Proteins
Confounding Factors (Epidemiology)
Sequence Alignment
Least-Squares Analysis
DNA Damage
Immune System
Cell Cycle
Body Weight
Breast Neoplasms
Pregnancy

Keywords

  • Aging
  • Genes
  • Genetics
  • Homology
  • Longevity

ASJC Scopus subject areas

  • Aging
  • Developmental Biology

Cite this

Conservation of pro-longevity genes among mammals. / Lindborg, Carter M.; Propert, Kathleen J.; Pignolo, Robert.

In: Mechanisms of Ageing and Development, Vol. 146-148, 01.03.2015, p. 23-27.

Research output: Contribution to journalArticle

Lindborg, Carter M. ; Propert, Kathleen J. ; Pignolo, Robert. / Conservation of pro-longevity genes among mammals. In: Mechanisms of Ageing and Development. 2015 ; Vol. 146-148. pp. 23-27.
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