Consensus statement on the diagnosis of multiple system atrophy

Sid Gilman, Phillip Low, Niall Quinn, Alberto Albanese, Yoav Ben-Shlomo, Clare Fowler, Horacio Kaufmann, Thomas Klockgether, Anthony Lang, Peter Lantos, Irene Litvan, Christopher Mathias, Eugene Oliver, David Robertson, Irwin Schatz, Gregor Wenning

Research output: Contribution to journalArticlepeer-review

248 Scopus citations

Abstract

We report the results of a consensus conference on the diagnosis of multiple system atrophy (MSA). We describe the clinical features of the disease, which include four domains: autonomic failure/urinary dysfunction, parkinsonism and cerebellar ataxia, and corticospinal dysfunction. We set criteria to define the relative importance of these features. The diagnosis of possible MSA requires one criterion plus two features from separate domains. The diagnosis of probable MSA requires the criterion for autonomic failure/urinary dysfunction plus poor levodopa responsive parkinsonism or cerebellar ataxia. The diagnosis of definite MSA requires pathological confirmation.

Original languageEnglish (US)
Pages (from-to)359-362
Number of pages4
JournalClinical Autonomic Research
Volume8
Issue number6
DOIs
StatePublished - 1998

Keywords

  • Autonomic insufficiency
  • Cerebellar ataxia
  • Glial cytoplasmic inclusions
  • Multiple system atrophy
  • Parkinsonism
  • Urinary dysfunction

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems
  • Clinical Neurology

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