Consensus statement on the diagnosis of multiple system atrophy

Sid Gilman; Phillip Low; Niall Quinn; Alberto Albanese; Yoav Ben-Shlomo; Clare Fowler; Horacio Kaufmann; Thomas Klockgether; Anthony Lang; Peter Lantos; Irene Litvan; Christopher Mathias; Eugene Oliver; David Robertson; Irwin Schatz; Gregor Wenning

doi:10.1007/BF02309628

Consensus statement on the diagnosis of multiple system atrophy

Sid Gilman, Phillip Low, Niall Quinn, Alberto Albanese, Yoav Ben-Shlomo, Clare Fowler, Horacio Kaufmann, Thomas Klockgether, Anthony Lang, Peter Lantos, Irene Litvan, Christopher Mathias, Eugene Oliver, David Robertson, Irwin Schatz, Gregor Wenning

Neurology

Research output: Contribution to journal › Article › peer-review

248 Scopus citations

Abstract

We report the results of a consensus conference on the diagnosis of multiple system atrophy (MSA). We describe the clinical features of the disease, which include four domains: autonomic failure/urinary dysfunction, parkinsonism and cerebellar ataxia, and corticospinal dysfunction. We set criteria to define the relative importance of these features. The diagnosis of possible MSA requires one criterion plus two features from separate domains. The diagnosis of probable MSA requires the criterion for autonomic failure/urinary dysfunction plus poor levodopa responsive parkinsonism or cerebellar ataxia. The diagnosis of definite MSA requires pathological confirmation.

Original language	English (US)
Pages (from-to)	359-362
Number of pages	4
Journal	Clinical Autonomic Research
Volume	8
Issue number	6
DOIs	https://doi.org/10.1007/BF02309628
State	Published - 1998

Keywords

Autonomic insufficiency
Cerebellar ataxia
Glial cytoplasmic inclusions
Multiple system atrophy
Parkinsonism
Urinary dysfunction

ASJC Scopus subject areas

Endocrine and Autonomic Systems
Clinical Neurology

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10.1007/BF02309628

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title = "Consensus statement on the diagnosis of multiple system atrophy",

abstract = "We report the results of a consensus conference on the diagnosis of multiple system atrophy (MSA). We describe the clinical features of the disease, which include four domains: autonomic failure/urinary dysfunction, parkinsonism and cerebellar ataxia, and corticospinal dysfunction. We set criteria to define the relative importance of these features. The diagnosis of possible MSA requires one criterion plus two features from separate domains. The diagnosis of probable MSA requires the criterion for autonomic failure/urinary dysfunction plus poor levodopa responsive parkinsonism or cerebellar ataxia. The diagnosis of definite MSA requires pathological confirmation.",

keywords = "Autonomic insufficiency, Cerebellar ataxia, Glial cytoplasmic inclusions, Multiple system atrophy, Parkinsonism, Urinary dysfunction",

author = "Sid Gilman and Phillip Low and Niall Quinn and Alberto Albanese and Yoav Ben-Shlomo and Clare Fowler and Horacio Kaufmann and Thomas Klockgether and Anthony Lang and Peter Lantos and Irene Litvan and Christopher Mathias and Eugene Oliver and David Robertson and Irwin Schatz and Gregor Wenning",

note = "Funding Information: This conference was supported in part by the Office of Rare Diseases and the National Institute of Neurological Disorders and Stroke, National Institutes of Health; Glaxo Wellcome, Inc.; Hoechst Marion Roussell; and Roberts Pharmaceutical Corporation.",

year = "1998",

doi = "10.1007/BF02309628",

language = "English (US)",

volume = "8",

pages = "359--362",

journal = "Clinical Autonomic Research",

issn = "0959-9851",

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number = "6",

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T1 - Consensus statement on the diagnosis of multiple system atrophy

AU - Gilman, Sid

AU - Low, Phillip

AU - Quinn, Niall

AU - Albanese, Alberto

AU - Ben-Shlomo, Yoav

AU - Fowler, Clare

AU - Kaufmann, Horacio

AU - Klockgether, Thomas

AU - Lang, Anthony

AU - Lantos, Peter

AU - Litvan, Irene

AU - Mathias, Christopher

AU - Oliver, Eugene

AU - Robertson, David

AU - Schatz, Irwin

AU - Wenning, Gregor

N1 - Funding Information: This conference was supported in part by the Office of Rare Diseases and the National Institute of Neurological Disorders and Stroke, National Institutes of Health; Glaxo Wellcome, Inc.; Hoechst Marion Roussell; and Roberts Pharmaceutical Corporation.

PY - 1998

Y1 - 1998

N2 - We report the results of a consensus conference on the diagnosis of multiple system atrophy (MSA). We describe the clinical features of the disease, which include four domains: autonomic failure/urinary dysfunction, parkinsonism and cerebellar ataxia, and corticospinal dysfunction. We set criteria to define the relative importance of these features. The diagnosis of possible MSA requires one criterion plus two features from separate domains. The diagnosis of probable MSA requires the criterion for autonomic failure/urinary dysfunction plus poor levodopa responsive parkinsonism or cerebellar ataxia. The diagnosis of definite MSA requires pathological confirmation.

AB - We report the results of a consensus conference on the diagnosis of multiple system atrophy (MSA). We describe the clinical features of the disease, which include four domains: autonomic failure/urinary dysfunction, parkinsonism and cerebellar ataxia, and corticospinal dysfunction. We set criteria to define the relative importance of these features. The diagnosis of possible MSA requires one criterion plus two features from separate domains. The diagnosis of probable MSA requires the criterion for autonomic failure/urinary dysfunction plus poor levodopa responsive parkinsonism or cerebellar ataxia. The diagnosis of definite MSA requires pathological confirmation.

KW - Autonomic insufficiency

KW - Cerebellar ataxia

KW - Glial cytoplasmic inclusions

KW - Multiple system atrophy

KW - Parkinsonism

KW - Urinary dysfunction

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JO - Clinical Autonomic Research

JF - Clinical Autonomic Research

IS - 6

ER -

Consensus statement on the diagnosis of multiple system atrophy

Abstract

Keywords

ASJC Scopus subject areas

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