Connectivity of epileptic brain regions in wake and sleep

Petr Klimes, Juliano J. Duque, Pavel Jurak, Josef Halamek, Gregory Alan Worrell

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Citations (Scopus)

Abstract

Focal epileptic brain is characterized by a region of pathological tissue seizure onset zone (SOZ) - the pathologic tissue generating seizures. During the interictal period (nonseizure) the SOZ is characterized by epileptiform activity - interictal spikes & high-frequency oscillations (HFO). The SOZ also exhibits hyper-synchrony and functional disconnection from the surrounding areas. Recent studies have described the synchrony inside the SOZ and surrounding tissue for just small sets of patients (2-4) and without any distinction in behavioral states. Wake and sleep cycles can, however, have a significant influence on SOZ activity. Here we show the results of connectivity analysis in three fundamental areas of the epileptic brain - inside SOZ, outside SOZ and bridging areas in 7 patients during wake and sleep. We observed increased synchrony inside SOZ and decreased synchrony on its edges (bridging areas) in specific frequency bands. We also detected significant differences of synchrony levels between wake and sleep periods in HFO frequencies. Our results provide additional insight into the properties of SOZ connectivity. Knowledge of these principles may prove useful for SOZ localization and understanding epileptic brain function in general.

Original languageEnglish (US)
Title of host publicationProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages2191-2194
Number of pages4
Volume2015-November
ISBN (Print)9781424492718
DOIs
StatePublished - Nov 4 2015
Event37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015 - Milan, Italy
Duration: Aug 25 2015Aug 29 2015

Other

Other37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015
CountryItaly
CityMilan
Period8/25/158/29/15

Fingerprint

Brain
Sleep
Seizures
Tissue
Frequency bands

ASJC Scopus subject areas

  • Computer Vision and Pattern Recognition
  • Signal Processing
  • Biomedical Engineering
  • Health Informatics

Cite this

Klimes, P., Duque, J. J., Jurak, P., Halamek, J., & Worrell, G. A. (2015). Connectivity of epileptic brain regions in wake and sleep. In Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS (Vol. 2015-November, pp. 2191-2194). [7318825] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/EMBC.2015.7318825

Connectivity of epileptic brain regions in wake and sleep. / Klimes, Petr; Duque, Juliano J.; Jurak, Pavel; Halamek, Josef; Worrell, Gregory Alan.

Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. Vol. 2015-November Institute of Electrical and Electronics Engineers Inc., 2015. p. 2191-2194 7318825.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Klimes, P, Duque, JJ, Jurak, P, Halamek, J & Worrell, GA 2015, Connectivity of epileptic brain regions in wake and sleep. in Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. vol. 2015-November, 7318825, Institute of Electrical and Electronics Engineers Inc., pp. 2191-2194, 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015, Milan, Italy, 8/25/15. https://doi.org/10.1109/EMBC.2015.7318825
Klimes P, Duque JJ, Jurak P, Halamek J, Worrell GA. Connectivity of epileptic brain regions in wake and sleep. In Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. Vol. 2015-November. Institute of Electrical and Electronics Engineers Inc. 2015. p. 2191-2194. 7318825 https://doi.org/10.1109/EMBC.2015.7318825
Klimes, Petr ; Duque, Juliano J. ; Jurak, Pavel ; Halamek, Josef ; Worrell, Gregory Alan. / Connectivity of epileptic brain regions in wake and sleep. Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. Vol. 2015-November Institute of Electrical and Electronics Engineers Inc., 2015. pp. 2191-2194
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