Connectivity network measures predict volumetric atrophy in mild cognitive impairment

Alzheimer's Disease Neuroimaging Initiative (ADNI)

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Alzheimer's disease (AD) is characterized by cortical atrophy and disrupted anatomic connectivity, and leads to abnormal interactions between neural systems. Diffusion-weighted imaging (DWI) and graph theory can be used to evaluate major brain networks and detect signs of a breakdown in network connectivity. In a longitudinal study using both DWI and standard magnetic resonance imaging (MRI), we assessed baseline white-matter connectivity patterns in 30 subjects with mild cognitive impairment (MCI, mean age 71.8 ± 7.5 years, 18 males and 12 females) from the Alzheimer's Disease Neuroimaging Initiative. Using both standard MRI-based cortical parcellations and whole-brain tractography, we computed baseline connectivity maps from which we calculated global "small-world" architecture measures, including mean clustering coefficient and characteristic path length. We evaluated whether these baseline network measures predicted future volumetric brain atrophy in MCI subjects, who are at risk for developing AD, as determined by 3-dimensional Jacobian "expansion factor maps" between baseline and 6-month follow-up anatomic scans. This study suggests that DWI-based network measures may be a novel predictor of AD progression.

Original languageEnglish (US)
Pages (from-to)S113-S120
JournalNeurobiology of aging
Volume36
Issue numberS1
DOIs
StatePublished - Jan 1 2015

Keywords

  • ADNI
  • Brain networks
  • Connectivity
  • DTI
  • Graph theory
  • Small worldness
  • TBM
  • Tractography
  • White matter

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

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