Connective tissue growth factor (CTGF) expression and outcome in adult patients with acute lymphoblastic leukemia

Olga Sala-Torra; Holly M. Gundacker; Derek L. Stirewalt; Paula A. Ladne; Era L. Pogosova-Agadjanyan; Marilyn L. Slovak; Cheryl L. Willman; Shelly Heimfeld; David H. Boldt; Jerald P. Radich

doi:10.1182/blood-2006-06-031096

Connective tissue growth factor (CTGF) expression and outcome in adult patients with acute lymphoblastic leukemia

Olga Sala-Torra, Holly M. Gundacker, Derek L. Stirewalt, Paula A. Ladne, Era L. Pogosova-Agadjanyan, Marilyn L. Slovak, Cheryl L. Willman, Shelly Heimfeld, David H. Boldt, Jerald P. Radich

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

Abstract

We compared the gene expression profile of adult acute lymphoblastic leukemia (ALL) to normal hematopoietic and non-ALL samples using oligonucleotide arrays. Connective tissue growth factor (CTGF) was the highest overexpressed gene in B-cell ALL compared with the other groups, and displayed heterogeneous expression, suggesting it might have prognostic relevance. CTGF expression was examined by quantitative reverse transcriptase-polymerase chain reaction (QRT-PCR) on 79 adult ALL specimens. CTGF expression levels were significantly increased in ALL cases with B-lineage (P < .001), unfavorable cytogenetics (P < .001), and blasts expressing CD34 (P < .001). In a multivariate proportional hazards model, higher CTGF expression levels corresponded to worsening of overall survival (OS; hazard ratio 1.36, for each 10-fold increase in expression; P = .019). Further studies are ongoing to confirm the prognostic value of CTGF expression in ALL and to investigate its role in normal and abnormal lymphocyte biology.

Original language	English (US)
Pages (from-to)	3080-3083
Number of pages	4
Journal	Blood
Volume	109
Issue number	7
DOIs	https://doi.org/10.1182/blood-2006-06-031096
State	Published - Apr 1 2007

ASJC Scopus subject areas

Biochemistry
Immunology
Hematology
Cell Biology

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@article{70124146a0bc4db187ff341dbaa70d7f,

title = "Connective tissue growth factor (CTGF) expression and outcome in adult patients with acute lymphoblastic leukemia",

abstract = "We compared the gene expression profile of adult acute lymphoblastic leukemia (ALL) to normal hematopoietic and non-ALL samples using oligonucleotide arrays. Connective tissue growth factor (CTGF) was the highest overexpressed gene in B-cell ALL compared with the other groups, and displayed heterogeneous expression, suggesting it might have prognostic relevance. CTGF expression was examined by quantitative reverse transcriptase-polymerase chain reaction (QRT-PCR) on 79 adult ALL specimens. CTGF expression levels were significantly increased in ALL cases with B-lineage (P < .001), unfavorable cytogenetics (P < .001), and blasts expressing CD34 (P < .001). In a multivariate proportional hazards model, higher CTGF expression levels corresponded to worsening of overall survival (OS; hazard ratio 1.36, for each 10-fold increase in expression; P = .019). Further studies are ongoing to confirm the prognostic value of CTGF expression in ALL and to investigate its role in normal and abnormal lymphocyte biology.",

author = "Olga Sala-Torra and Gundacker, {Holly M.} and Stirewalt, {Derek L.} and Ladne, {Paula A.} and Pogosova-Agadjanyan, {Era L.} and Slovak, {Marilyn L.} and Willman, {Cheryl L.} and Shelly Heimfeld and Boldt, {David H.} and Radich, {Jerald P.}",

year = "2007",

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doi = "10.1182/blood-2006-06-031096",

language = "English (US)",

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pages = "3080--3083",

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AU - Sala-Torra, Olga

AU - Gundacker, Holly M.

AU - Stirewalt, Derek L.

AU - Ladne, Paula A.

AU - Pogosova-Agadjanyan, Era L.

AU - Slovak, Marilyn L.

AU - Willman, Cheryl L.

AU - Heimfeld, Shelly

AU - Boldt, David H.

AU - Radich, Jerald P.

PY - 2007/4/1

Y1 - 2007/4/1

N2 - We compared the gene expression profile of adult acute lymphoblastic leukemia (ALL) to normal hematopoietic and non-ALL samples using oligonucleotide arrays. Connective tissue growth factor (CTGF) was the highest overexpressed gene in B-cell ALL compared with the other groups, and displayed heterogeneous expression, suggesting it might have prognostic relevance. CTGF expression was examined by quantitative reverse transcriptase-polymerase chain reaction (QRT-PCR) on 79 adult ALL specimens. CTGF expression levels were significantly increased in ALL cases with B-lineage (P < .001), unfavorable cytogenetics (P < .001), and blasts expressing CD34 (P < .001). In a multivariate proportional hazards model, higher CTGF expression levels corresponded to worsening of overall survival (OS; hazard ratio 1.36, for each 10-fold increase in expression; P = .019). Further studies are ongoing to confirm the prognostic value of CTGF expression in ALL and to investigate its role in normal and abnormal lymphocyte biology.

AB - We compared the gene expression profile of adult acute lymphoblastic leukemia (ALL) to normal hematopoietic and non-ALL samples using oligonucleotide arrays. Connective tissue growth factor (CTGF) was the highest overexpressed gene in B-cell ALL compared with the other groups, and displayed heterogeneous expression, suggesting it might have prognostic relevance. CTGF expression was examined by quantitative reverse transcriptase-polymerase chain reaction (QRT-PCR) on 79 adult ALL specimens. CTGF expression levels were significantly increased in ALL cases with B-lineage (P < .001), unfavorable cytogenetics (P < .001), and blasts expressing CD34 (P < .001). In a multivariate proportional hazards model, higher CTGF expression levels corresponded to worsening of overall survival (OS; hazard ratio 1.36, for each 10-fold increase in expression; P = .019). Further studies are ongoing to confirm the prognostic value of CTGF expression in ALL and to investigate its role in normal and abnormal lymphocyte biology.

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DO - 10.1182/blood-2006-06-031096

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JO - Blood

JF - Blood

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ER -

Connective tissue growth factor (CTGF) expression and outcome in adult patients with acute lymphoblastic leukemia

Abstract

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